Xenotransplantation of human adipose-derived stem cells in the regeneration of a rabbit peripheral nerve

Lasso, José M.; Cano, R.; Castro, Yolanda; Arenas, L.; García, José Perea; Fernández‐Santos, María Eugenia

doi:10.1016/j.bjps.2015.07.005

Cited by 25 publications

(26 citation statements)

References 38 publications

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“…Studies have shown that xenotransplantation of human AdMSCs into different animal models was safe and effective for tissue repair and regeneration152728. In a rat model of cisplatin-induced kidney injury, xenotransplantation of human AdMSCs led to decreased expression level of proinflammatory mediators22.…”

Section: Discussionmentioning

confidence: 99%

Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury

Zhou

Song

Shen

et al. 2017

Sci Rep

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Stem cells therapy has been suggested as a promising option for the treatment of acute kidney injury (AKI). This study was performed to compare the abilities of xenogenic transplantation of human adipose stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (AdMSCs) to facilitate the recovery of renal function and structure in a rat model of ischemia/reperfusion (IR) induced AKI. SVF or AdMSCs were transplanted to the injured kidney through intra-parenchymal injection. Significantly improved renal function and reduced tubular injury were observed in SVF and AdMSCs groups. Administration of SVF or AdMSCs contributed to significantly improved cell proliferation and markedly reduced cell apoptosis in parallel with reduced microvascular rarefaction in injured kidney. IR injury resulted in higher levels of inflammatory cytokines, whereas xenogenic transplantation of SVF or AdMSCs reduced but not induced inflammatory cytokines expression. Additionally, in vitro study showed that administration of SVF or AdMSCs could also significantly promote the proliferation and survival of renal tubular epithelial cells underwent hypoxia/reoxygenation injury through secreting various growth factors. However, cell proliferation was significantly promoted in SVF group than in AdMSCs group. In conclusion, our study demonstrated that administration of SVF or AdMSCs was equally effective in attenuating acute renal IR injury.

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Section: Discussionmentioning

confidence: 99%

Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury

Zhou

Song

Shen

et al. 2017

Sci Rep

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“…One study used human nerves (sural nerve) [9]. Six studies used human mesenchymal stem cells laden in autologous or synthetic conduits [8,10,[13][14][15]20]. There have been no studies with humans as recipients for xenografts.…”

Section: Resultsmentioning

confidence: 99%

“…Nerve conduits are useful for nerve restoration. Xenogeneic stem cell-laden conduits prove an increased regenerative ability [8,10,[13][14][15]20].…”

Section: Human Cells 40 20mentioning

confidence: 99%

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Current Status in Peripheral Nerve Xenotransplantation

Lasso¹,

Deleyto²

2017

Xenotransplantation - New Insights

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Nerve grafts are used to repair segmental defects in peripheral nerves. However, autografts and even allografts are limited for clinical use. Xenotransplantation offers a potentially unlimited source for tissue transplantation. We have conducted a systematic review of the literature, aiming to clarify the latest and more appealing proposals and discoveries in nerve xenotransplantation. A total of 22 articles were retrieved, all of them experimentally controlled studies in animals. There are no current studies in humans. Fresh xenografts provoke an immune response that leads to graft rejection. Immunosuppressive drugs or pretreatment of the grafts are the preferred methods against immune rejection. Recently, investigative groups have proposed the use of acellular nerve xenografts, which do not elicit immune rejection while they do allow and promote axonal regeneration. The addition of human stem cells increases nerve growth. Limits to the analyzed studies are the absence of trials in humans and the short length of the nerve defects that have been successfully repaired. Further investigations and clinical trials are needed before nerve xenografting is accepted as a valid method of nerve repair.

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“…In vivo studies have revealed that ASCs-differentiated Schwann-like cells promoted nerve repair and regeneration when delivered in distinct scaffolds, such as fibrin and silicon [22][23][24][25][26][27][28]. Tomita et al demonstrated improved cutaneous nerve regeneration in skin flaps after treatment with ASCs-differentiated Schwann-like cells [29].…”

mentioning

confidence: 99%

The Use of Adipose Derived Cells for Skin Nerve Regeneration – Short Review of Experimental Research

Klar¹,

Zimoch²,

Biedermann³

2017

J Tissue Sci Eng

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Xenotransplantation of human adipose-derived stem cells in the regeneration of a rabbit peripheral nerve

Cited by 25 publications

References 38 publications

Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury

Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury

Current Status in Peripheral Nerve Xenotransplantation

The Use of Adipose Derived Cells for Skin Nerve Regeneration – Short Review of Experimental Research

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