Xenotransplantation in immunodeficient mice to study ovarian follicular development in domestic animals

Bols, P.E.J.; Aerts, J.M.J.; Langbeen, A.; Goovaerts, Inge; Leroy, J.L.M.R.

doi:10.1016/j.theriogenology.2009.10.002

Cited by 23 publications

(18 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yet despite its potential, xenotransplantation is still considered by many to be an unsafe form of transplantation. Xeno-transplantation carries a high probability of organ rejection and transmission of infectious agents from the donor tissue [15]. Lastly, the shorter life span of donor animals means that their organ would age at a faster rate than a human organ [12].…”

Section: Kidney Transplantation Methodsmentioning

confidence: 99%

Untitled

2017

JABB

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is the leading cause of death for individuals suffering from end-stage kidney failure. While kidney transplantation is the most viable solution to CKD, it has many challenges and limitations. This review evaluates kidney transplant rejection and the various transplantation methods that may be employed to treat CKD. Kidney rejection and long-term transplant survival is the main concern regarding transplantation attempts. Thus, scientist must screen and strategize appropriately to ensure kidney transplant survival. Tissue engineering techniques are explored as means to improve upon transplantation attempts. Research into ensuring adequate organ scaffold design has become crucial in the field of regenerative medicine. Furthermore, the role of integrins is discussed as a central component for future tissue engineering techniques, by taking the study of scaffold design to the molecular level. Finally, a glimpse into the current advancements of three-dimensional bioprinting highlights the future of tissue engineering and shows how the field of regenerative medicine is taking another step closer to developing "home-grown" kidneys. With the prospect of generating a fully lab-created, personalized kidney, CKD may one day be treated without encountering any of the limitations that have hindered previous attempts.

show abstract

Section: Kidney Transplantation Methodsmentioning

confidence: 99%

Untitled

2017

JABB

View full text Add to dashboard Cite

show abstract

“…Xeno-transplantation carries a high probability of organ rejection and transmission of infectious agents from the donor tissue. 15 Lastly, the shorter life span of donor animals means that their organ would age at a faster rate than a human organ. following transplantation.…”

Section: Kidney Transplantation Methodsmentioning

confidence: 99%

Home-Grown Kidneys: Challenges and Mechanisms Behind Tissue Engineering for the Treatment of Chronic Kidney Disease

Tawil¹

2017

JABB

View full text Add to dashboard Cite

“…In the 19th century, tissues (mainly the skin) and during the 20th century, vascularised organs were attempted to be grafted into humans without success [35]. The reason for these failures was the acute rejection of the transplanted tissue by the immune system [36]. The development of transgenic immunotolerant animal models allowed xenotransplantation to have new insights in the research field.…”

Section: Xenotransplantation a Tool To Evaluate The Safety Of Ovamentioning

confidence: 99%

“…The development of transgenic immunotolerant animal models allowed xenotransplantation to have new insights in the research field. Today, some mice strains have mutations that make them sufficiently immunodeficient to permit xenotransplantation [36]. Among them, nude mice that are athymic, and thus T-cell deficient, [37] and severe combined immunodeficient mice (SCID) carrying an autosomal recessive mutation that severely affect lymphopoiesis, which makes mice that are homozygous for this mutation deficient in B and T lymphocytes [38], are the most frequently used for ovarian tissue xenografts.…”

Section: Xenotransplantation a Tool To Evaluate The Safety Of Ovamentioning

confidence: 99%

“…Xenotransplantation models have initially focussed on studying ovarian follicular development, in which primordial follicles are activated in an immunocompromised animal model and, after initial growth, are transferred to an in vitro culture system [36]. This approach eliminates the risk of cancer cell reintroduction, and, additionally, the problematic unaccomplished phase of primordial follicle culture is bypassed [36]. Unfortunately, the use of xenotransplantation to mature follicles “in vivo” is still not ready to be used in clinical applications, as its safety and ethical issues have yet to be discussed [48].…”

Section: Xenotransplantation a Tool To Evaluate The Safety Of Ovamentioning

confidence: 99%

See 1 more Smart Citation

Safety of Ovarian Tissue Autotransplantation for Cancer Patients

Bockstaele

Tsépélidis

Dechene

et al. 2012

Obstetrics and Gynecology International

View full text Add to dashboard Cite

Cancer treatments can induce premature ovarian failure in almost half of young women suffering from invasive neoplasia. Cryopreservation of ovarian cortex and subsequent autotransplantation of frozen-thawed tissue have emerged as promising alternatives to conventional fertility preservation technologies. However, human ovarian tissue is generally harvested before the administration of gonadotoxic treatment and could be contaminated with malignant cells. The safety of autotransplantation of ovarian cortex remains a major concern for fertility preservation units worldwide. This paper discusses the main tools for detecting disseminated cancer cells currently available, their limitations, and clinical relevance.

show abstract

Xenotransplantation in immunodeficient mice to study ovarian follicular development in domestic animals

Cited by 23 publications

References 65 publications

Untitled

Untitled

Home-Grown Kidneys: Challenges and Mechanisms Behind Tissue Engineering for the Treatment of Chronic Kidney Disease

Safety of Ovarian Tissue Autotransplantation for Cancer Patients

Contact Info

Product

Resources

About