Xenotransplantation and the Liver

Platt, Jeffrey L.; Fox, Ira J.

doi:10.1016/b978-0-7216-0118-2.50089-6

Cited by 2 publications

(3 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, antibody-mediated injury is observed in organ grafts to a much greater extent than in cell or tissue grafts. Furthermore, because immunoglobulins are largely confined to vascular spaces, alloreactive antibodies have minimal direct impact on parenchymal cells (9, 10). …”

Section: Transplant Type and Susceptibility To Antibody-mediated Injurymentioning

confidence: 99%

“…In some cases antibody capable of binding to and injuring the graft may be present but is not detected by assays in which leukocytes are used as the target. For example, antibodies specific for major-histocompatibility-complex class I–related chain A antigens, which are not expressed on leukocytes (10) but are expressed on endothelial cells, have been found to be cytotoxic in the presence of serum complement (19). As another example, antiendothelial cell antibodies have also been linked to rejection in HLA- identical sibling transplants (20).…”

Section: Hyperacute Rejectionmentioning

confidence: 99%

See 1 more Smart Citation

The role of antibodies in transplantation

Chang

Platt

2009

Transplantation Reviews

Self Cite

View full text Add to dashboard Cite

For the past forty years T-cells have been considered the primary threat to the survival of allografts. However antibodies can induce severe vascular disease of organ transplants and this disease, particularly "antibody-mediated" rejection, has become a major clinical challenge. Not only do antibodies cause rejection, the rejection caused by antibodies resists treatment by conventional drug regimens. On the other hand, antibodies can induce a condition in which grafts seemingly resist antibody-mediated injury, which is accommodation. In this communication we discuss the role of antibodies in the diagnosis and pathogenesis of rejection and accommodation, and suggest what we consider the major gaps in knowledge and directions research into this subject might productively take.

show abstract

Section: Transplant Type and Susceptibility To Antibody-mediated Injurymentioning

confidence: 99%

Section: Hyperacute Rejectionmentioning

confidence: 99%

The role of antibodies in transplantation

Chang

Platt

2009

Transplantation Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although undoubtedly facing many practical, social and ethical hurdles and many years from clinical reality, xenotransplantation, or the transplantation of animal organs, could potentially solve both problems [43,44]. Homogenous inbred animal herds, composed of either pig or non-endangered primate species, would represent a near unlimited source of transplantable organs.…”

Section: Alternative Sources For Donor Graftsmentioning

confidence: 99%

The status of liver transplantation for hepatitis C

Cameron¹,

Busuttil²

2006

Expert Opinion on Biological Therapy

View full text Add to dashboard Cite

The hepatitis C virus (HCV) infects 3% of the world's population, or approximately 170 million people. Most of those acutely infected progress to chronic infection and are unresponsive to existing antiviral treatment. Over a 20-year period, chronic HCV infection leads to cirrhosis and the sequelae of end-stage liver disease, including hepatic encephalopathy, ascites, variceal haemorrhage and hepatocellular carcinoma. Orthotopic liver transplantation (OLT) is the optimal treatment for decompensated HCV cirrhosis, but is limited by organ availability and universal graft reinfection. This review discusses the results with OLT for HCV from the Dumont-UCLA Liver Transplant Center and discusses future directions in the management of HCV.

show abstract

Xenotransplantation and the Liver

Cited by 2 publications

References 88 publications

The role of antibodies in transplantation

The role of antibodies in transplantation

The status of liver transplantation for hepatitis C

Contact Info

Product

Resources

About