Xenônio: farmacologia e uso clínico

Mendes, Florentino Fernandes; Gomes, Marcos Emanuel Wortmann

doi:10.1590/s0034-70942003000400013

Cited by 2 publications

(1 citation statement)

References 37 publications

(74 reference statements)

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“…It was discovered at the initial stages of the research that xenon pressure of 0.9 mPa causes intense foaming during warming which leads to cell death. It has been known that xenon clathrates lose their stability when the temperature during warming is increased, and change to the gas phase [29,30]. For this purpose, if there is enough water to dissolve noble gases, they can be gradually removed from the cells.…”

Section: Storage Period Daysmentioning

confidence: 99%

Use of Inert Gases for the Preservation of Nuclear Blood Cells

Khudyakov

Полежаева

Зайцева

et al. 2019

Braz. arch. biol. technol.

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The subject of the study was the stability of human white blood cell membranes subject to noble gases (xenon ad krypton, 0.6 mPa) clathrate cryoanabiosis (-80°C). A unique portable stainless steel low pressure container with a compartment for flexible plastic container was designed to ensure that the cells are saturated with gases. The samples were warmed after 1 and 30 days in a water bath (+38°C) for 35-50 sec, while the container was being tilted (2-3 times per second), until the temperature of the biological object reached +3±1°C. It was demonstrated that after 30 days of clathrate anabiosis (-80°C) over 95% (of the original number) of leukocytes remain viable, and cell membranes of 54.5±3.4% of them is resistant to trypan blue; granulocyte survival rate is 73.5±2.7%, original lipid peroxidation rate and antioxidant activity are retained. Biological object cryopreservation in noble gases environment is a promising trend in biology and medicine.

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Section: Storage Period Daysmentioning

confidence: 99%

Use of Inert Gases for the Preservation of Nuclear Blood Cells

Khudyakov

Полежаева

Зайцева

et al. 2019

Braz. arch. biol. technol.

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Safety of parapulmonal application of xenon in the experiment

Khinovker

Veselova

Корячкин

et al. 2022

Innovacionnaâ medicina Kubani

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Pain syndrome is the most common reason for patients to seek medical care, the importance of which is steadily increasing in the structure of the total incidence. To optimize costs and ensure high-quality treatment of patients with chronic pain syndrome it is necessary to study existing drugs and methods and introduce new ones. Based on theoretical data on the use of inert gases in medicine, a hypothesis was put forward that xenon could have a pronounced analgesic effect when administered subcutaneously. This study is aimed at confirming the safety of xenon in parapulmonary administration to rats.

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Xenônio: farmacologia e uso clínico

Abstract: RESUMO

Cited by 2 publications

References 37 publications

Use of Inert Gases for the Preservation of Nuclear Blood Cells

Use of Inert Gases for the Preservation of Nuclear Blood Cells

Safety of parapulmonal application of xenon in the experiment

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