Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats

Yoshida, Hitoshi; Kushikata, Tetsuya; Kubota, Takeshi; Hirota, Kazuyoshi; Ishihara, Hironori; Matsuki, Akitomo

doi:10.1007/bf03016198

Cited by 17 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given these differences, the levels of different catecholamines do not necessarily change in the same manner. In a previous report, xenon was shown to induce secretion of NE from the nerve endings of the posterior hypothalamus [30], but in the present study, no effect of xenon on NE release into the plasma was apparent.…”

Section: Discussioncontrasting

confidence: 63%

Effect of xenon on catecholamine and hemodynamic responses to surgical noxious stimulation in humans

Kobayashi

Katoh

Bito³

et al. 2006

Journal of Clinical Anesthesia

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 63%

Effect of xenon on catecholamine and hemodynamic responses to surgical noxious stimulation in humans

Kobayashi

Katoh

Bito³

et al. 2006

Journal of Clinical Anesthesia

View full text Add to dashboard Cite

“…NA levels returned to baseline after N 2 O was discontinued. Neither 30% nor 60% N 2 O led to a LORR in this study (Yoshida et al. 2001).…”

Section: Changes In Baseline Transmitter Levels and Their Potential Ccontrasting

confidence: 65%

The in vivo neurochemistry of the brain during general anesthesia

Müller

Pum²,

Amato

et al. 2011

Journal of Neurochemistry

View full text Add to dashboard Cite

J. Neurochem. (2011) 119, 419–446. Abstract Anesthesia describes a complex state composed of immobility, amnesia, hypnosis (sleep or loss of consciousness), analgesia, and muscle relaxation. Bottom‐up approaches explain anesthesia by an interaction of the anesthetic with receptor proteins in the brain, whereas top‐down approaches consider predominantly cortical and thalamic network activity and connectivity. Both approaches have a number of explanatory gaps and as yet no unifying view has emerged. In addition to a direct interaction with primary target receptor proteins, general anesthetics have massive effects on neurotransmitter activity in the brain. They can change basal transmitter levels by interacting with neuronal activity, transmitter synthesis, release, reuptake and metabolism. By that way, they can affect a great number of neurotransmitter systems and receptors. Here, we review how different general anesthetics affect extracellular activity of neurotransmitters in the brain during induction, maintenance, and emergence from anesthesia and which functional consequences this may have. Commonalities and differences between different groups of anesthetics in their action on neurotransmitter activity are discussed. We also review how general anesthetics affect the response dynamics of the neurotransmitter systems after sensory stimulation. More than 30 years of research have now yielded a complex picture of the effects of general anesthetics on brain neurotransmitter basal activity and response dynamics. It is suggested that analyzing the effects on neurotransmitter activity is the logical next step after protein interactions in a bottom‐up analysis of anesthetic action in the brain on the way to a unifying view of anesthesia.

show abstract

“…Therefore, the high baseline catecholamine concentrations observed in the instrumented pig model may be caused by the ketamine masking or even abolishing a xenon-related increase of catecholamine concentrations. In contrast to volatile anaesthetics, xenon has been shown to be an NMDA receptor ligand (Yamakura & Harris 2000) and to increase catecholamine release in the brain (Yoshida et al 2001). Stimulation of noradrenergic neurons in the hypothalamus may be one mechanism contributing to the sympathotonic effects of xenon (Preckel et al 2006).…”

Section: Catecholamines During Xenon Anaesthesiamentioning

confidence: 99%

The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs

et al. 2008

View full text Add to dashboard Cite

SummaryThe noble gas xenon seems to have minimal cardiovascular side-effects and so may be an ideal anaesthetic agent when investigating cardiovascular physiology. In comparison with standard modern anaesthetics, we investigated the haemodynamic and hormonal effects of xenon in Beagle dogs. After a 30 min baseline period, anaesthesia was induced with propofol and maintained with either (1) 1.2% isoflurane/70% nitrous oxide (N 2 O), (2) 0.8% isoflurane/ 0.5 mg/kg/min remifentanil or (3) 63% xenon/0.5 mg/kg/min remifentanil (n ¼ 6 per group).Haemodynamics were recorded and blood samples taken before and 60 min after induction. Mean arterial blood pressure (MAP) was higher in conscious dogs than during isoflurane/N 2 O (86 + 2 vs. 65 + 2 mmHg, mean + SEM) and isoflurane/remifentanil anaesthesia (95 + 2 vs. 67 + 3 mmHg), whereas MAP did not decrease significantly in response to xenon/ remifentanil anaesthesia (96 + 4 vs. 85 + 6 mmHg). Bradycardia was present during isoflurane/remifentanil (54 + 2/min) and xenon/remifentanil (40 + 3/min), but not during isoflurane/N 2 O anaesthesia (98 + 3/min, P , 0.05). Xenon/remifentanil anaesthesia induced the highest reduction in cardiac output (CO) ( -61%), and the highest increase in systemic vascular resistance (þ120%) among all treatment groups (P , 0.05). A simultaneous increase in endogenous adrenaline and noradrenaline concentrations could only be observed in the xenon/remifentanil group, whereas angiotensin II and vasopressin concentrations increased in all groups. In conclusion, xenon/remifentanil anaesthesia maintains MAP but reduces heart rate and CO and is associated with a considerable stimulation of vasopressor hormones in Beagle dogs. Therefore, xenon/remifentanil exerts a new quality of adverse haemodynamic effects different from volatile anaesthetics and may not perform better during studies of cardiovascular physiology.

show abstract

Xenon inhalation increases norepinephrine release from the anterior and posterior hypothalamus in rats

Cited by 17 publications

References 17 publications

Effect of xenon on catecholamine and hemodynamic responses to surgical noxious stimulation in humans

Effect of xenon on catecholamine and hemodynamic responses to surgical noxious stimulation in humans

The in vivo neurochemistry of the brain during general anesthesia

The haemodynamic and catecholamine response to xenon/remifentanil anaesthesia in Beagle dogs

Contact Info

Product

Resources

About