Xenon and Isoflurane Reduce Left Ventricular Remodeling after Myocardial Infarction in the Rat

Röhl, Anna Bettina; Funcke, Sandra; Becker, Michael; Goetzenich, Andreas; Berne, Christian; Rossaint, Rolf; Steendijk, Paul; Hein, Marc

doi:10.1097/aln.0b013e31828744c0

Cited by 25 publications

(24 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The isoflurane may attenuate the deleterious effects caused by ventricular remodeling as demonstrated by Roehl and collaborators [66]. However, all animals underwent to the same anesthesia protocol being exposed to isoflurane for a short time, approximately 2 minutes.…”

Section: Discussionmentioning

confidence: 99%

Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

et al. 2016

View full text Add to dashboard Cite

PurposeTherapeutic strategies that modulate ventricular remodeling can be useful after acute myocardial infarction (MI). In particular, statins may exert effects on molecular pathways involved in collagen metabolism. The aim of this study was to determine whether treatment with atorvastatin for 4 weeks would lead to changes in collagen metabolism and ventricular remodeling in a rat model of MI.MethodsMale Wistar rats were used in this study. MI was induced in rats by ligation of the left anterior descending coronary artery (LAD). Animals were randomized into three groups, according to treatment: sham surgery without LAD ligation (sham group, n = 14), LAD ligation followed by 10mg atorvastatin/kg/day for 4 weeks (atorvastatin group, n = 24), or LAD ligation followed by saline solution for 4 weeks (control group, n = 27). After 4 weeks, hemodynamic characteristics were obtained by a pressure-volume catheter. Hearts were removed, and the left ventricles were subjected to histologic analysis of the extents of fibrosis and collagen deposition, as well as the myocyte cross-sectional area. Expression levels of mediators involved in collagen metabolism and inflammation were also assessed.ResultsEnd-diastolic volume, fibrotic content, and myocyte cross-sectional area were significantly reduced in the atorvastatin compared to the control group. Atorvastatin modulated expression levels of proteins related to collagen metabolism, including MMP1, TIMP1, COL I, PCPE, and SPARC, in remote infarct regions. Atorvastatin had anti-inflammatory effects, as indicated by lower expression levels of TLR4, IL-1, and NF-kB p50.ConclusionTreatment with atorvastatin for 4 weeks was able to attenuate ventricular dysfunction, fibrosis, and left ventricular hypertrophy after MI in rats, perhaps in part through effects on collagen metabolism and inflammation. Atorvastatin may be useful for limiting ventricular remodeling after myocardial ischemic events.

show abstract

Section: Discussionmentioning

confidence: 99%

Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Xenon has also been shown to protect isolated rabbit hearts from ischemia/reperfusion injury, 16 an effect that was abolished by the specific mitoK ATP channel blocker 5-hydroxydecanoate 16 . Along similar lines, xenon limits the mid-term ventricular remodeling triggered by myocardial infarction in neonate rats, resulting in improved contractility and increased ejection fraction 18 . Finally, xenon has been shown to reduce the renal allograft injury that is generally associated with prolonged hypothermic graft storage in multiple rat models of transplantation 4 , 19 , 20 .…”

Section: Resultsmentioning

confidence: 94%

“…Xenon has been shown to mediate prominent neuroprotective, 8 , 11 - 15 cardioprotective 16 - 18 and nephroprotective 4 , 19 , 20 effects in vivo. Thus, xenon protects the fetal brain in rat and piglet models of intrauterine perinatal asphyxia, a process that is accompanied by a significant reduction in neuronal apoptosis, 11 , 12 , 14 , 15 inhibits nitrous oxide- and isoflurane-induced neuronal death (and the consequent cognitive impairment) in newborn rats 13 and blunts the death of neurons triggered by the occlusion of the middle cerebral artery in rodents 8 .…”

Section: Resultsmentioning

confidence: 99%

“…Nonetheless, at least some of these elements can interact in a stabilizing fashion with the active site of specific enzymes and receptors 6 , 7 . Of note, argon and xenon (but less so helium, krypton, neon, and radon) have been shown to mediate consistent neuroprotective, 8 - 15 cardioprotective, 16 - 18 and nephroprotective 4 , 19 , 20 effects in vitro, ex vivo, and in vivo. Though the molecular mechanisms underlying these observations remain largely undefined, it has been proposed that the cytoprotective effects of noble gases might result from the opening of the mitochondrial ATP-sensitive K (mitoK ATP ) channels 16 , 21 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antiapoptotic activity of argon and xenon

et al. 2013

View full text Add to dashboard Cite

Although chemically non-reactive, inert noble gases may influence multiple physiological and pathological processes via hitherto uncharacterized physical effects. Here we report a cell-based detection system for assessing the effects of pre-defined gas mixtures on the induction of apoptotic cell death. In this setting, the conventional atmosphere for cell culture was substituted with gas combinations, including the same amount of oxygen (20%) and carbon dioxide (5%) but 75% helium, neon, argon, krypton, or xenon instead of nitrogen. The replacement of nitrogen with noble gases per se had no effects on the viability of cultured human osteosarcoma cells in vitro. Conversely, argon and xenon (but not helium, neon, and krypton) significantly limited cell loss induced by the broad-spectrum tyrosine kinase inhibitor staurosporine, the DNA-damaging agent mitoxantrone and several mitochondrial toxins. Such cytoprotective effects were coupled to the maintenance of mitochondrial integrity, as demonstrated by means of a mitochondrial transmembrane potential-sensitive dye and by assessing the release of cytochrome c into the cytosol. In line with this notion, argon and xenon inhibited the apoptotic activation of caspase-3, as determined by immunofluorescence microscopy coupled to automated image analysis. The antiapoptotic activity of argon and xenon may explain their clinically relevant cytoprotective effects.

show abstract

“…[12,13] In addition, in recent years, it was shown that xenon had neuroprotective, cardioprotective, and renoprotective effects in different animal models subjected to preconditioning, real-time conditioning, and postconditioning. [14–17] However, the effects of xenon on respiratory function in patients with Stanford type A AAD during cardiopulmonary bypass (CPB) with DHCA remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection

Jin¹,

Yang²,

Pan

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

Xenon and Isoflurane Reduce Left Ventricular Remodeling after Myocardial Infarction in the Rat

Abstract: Compared to isoflurane and s-ketamine, xenon limited progressive adverse cardiac remodeling and contractile dysfunction 28 days after perioperative myocardial infarction.

Cited by 25 publications

References 57 publications

Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism

Antiapoptotic activity of argon and xenon

Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection

Contact Info

Product

Resources

About