Xenon anaesthesia for all, or only a select few?

Neice, Andrew; Zornow, Mark H.

doi:10.1111/anae.13569

Cited by 26 publications

(24 citation statements)

References 20 publications

(25 reference statements)

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“…[1] Xe possesses an umber of desirable properties as novel anaesthetic gas such as favourable hemodynamics,l ack of metabolism, and low solubility. [2] Currently,X ei sm erely produced as ab y-product from cryogenic distillation of air. Because of the low abundance in the Earthsa tmosphere (0.087 ppmv), intensive capital investment and energy consumption lead to an extremely high Xe price ($30,000-$60,000/m 3 gas,STP ).…”

Section: Introductionmentioning

confidence: 99%

Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics

et al. 2019

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Xe is only produced by cryogenic distillation of air, and its availability is limited by the extremely low abundance. Therefore, Xe recovery after usage is the only way to guarantee sufficient supply and broad application. Herein we demonstrate DD3R zeolite as a benchmark membrane material for CO2/Xe separation. The CO2 permeance after an optimized membrane synthesis is one order magnitude higher than for conventional membranes and is less susceptible to water vapour. The overall membrane performance is dominated by diffusivity selectivity of CO2 over Xe in DD3R zeolite membranes, whereby rigidity of the zeolite structure plays a key role. For relevant anaesthetic composition (<5 % CO2) and condition (humid), CO2 permeance and CO2/Xe selectivity stabilized at 2.0×10−8 mol m−2 s−1 Pa−1 and 67, respectively, during long‐term operation (>320 h). This endows DD3R zeolite membranes great potential for on‐stream CO2 removal from the Xe‐based closed‐circuit anesthesia system. The large cost reduction of up to 4 orders of magnitude by membrane Xe‐recycling (>99+%) allows the use of the precious Xe as anaesthetics gas a viable general option in surgery.

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Section: Introductionmentioning

confidence: 99%

Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics

et al. 2019

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“…In addition to its efficacy and safety, Xe is also an environmentally-friendly alternative to halocarbon anesthetics such as sevoflurane, desflurane, and isoflurane. The primary disadvantage of xenon is its high price, roughly $10 per L, which stems from the relative scarcity of atmospheric Xe (only 87 ppb in dry air) (Neice & Zornow, 2016). Currently, Xe is prepared on an industrial scale as a byproduct of liquid oxygen and nitrogen production by fractional distillation of liquefied air.…”

Section: Introductionmentioning

confidence: 99%

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Roose

Zemerov

Dmochowski

2018

Methods in Enzymology

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The physiological activity of xenon has long been recognized, though the exact nature of its interactions with biomolecules remains poorly understood. Xe is an inert noble gas, but can act as a general anesthetic, most likely by binding internal hydrophobic cavities within proteins. Understanding Xe-protein interactions, therefore, can provide crucial insight regarding the mechanism of Xe anesthesia and potentially other general anesthetic agents. Historically, Xe-protein interactions have been studied primarily through X-ray crystallography and nuclear magnetic resonance (NMR). In this chapter, we first describe our methods for preparing Xe derivatives of protein crystals and identifying Xe-binding sites. Second, we detail our procedure for Xe hyper-CEST NMR spectroscopy, a versatile NMR technique well suited for characterizing the weak, transient nature of Xe-protein interactions.

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“…Additionally, Xe is shown to be a potential candidate for anesthetics applications. Xe has high chemical stability, low flammability, low solubility in blood, minimal respiratory side effects, low interactions with drug molecules, which makes it a perfect candidate to be used as an anesthetics (Neice and Zornow, 2016). It can bind to proteins such as myoglobins as well as bilayer lipids through temporary polarization of its electrons (Franks, 2008).…”

Section: Introductionmentioning

confidence: 99%

Grand Canonical Monte Carlo Modeling of Anesthetic Xe Separation from Exhale Gas Mixtures Using Metal Organic Frameworks

Gürdal

2019

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Xe has been shown to be a promising candidate for anesthetic applications. However, its high price prevents its usage in clinical industry. An alternative approach is to recover Xe from anesthetic exhale gas mixture and recycle it to the inhale gas stream. Although, many membranes and/or adsorbents have been proposed for recovering anesthetic Xe, using metal organic frameworks (MOFs) for adsorption based separation of anesthetic Xe exhale gas mixtures has been newly studied. MOFs have tunable pore sizes, large surface areas, and high porosities which make them potential candidates for gas separation applications. Currently, very little is known about anesthetic Xe recovery performances of MOFs. We theoretically investigate adsorption based separation of single component and binary mixtures of CO2, Xe, and N2 in three MOFs, namely CECYOY, SUDBOI, and ZUQPOQ. Single component and binary adsorption isotherms and adsorption selectivities are calculated using Grand Canonical Monte Carlo simulations for each MOF in order to characterize their performances as adsorbents. Results suggest that while MOFs prefer adsorption of CO2 for CO2/Xe mixture, Xe adsorption is favorable in the case of Xe/N2 mixture. While SUDBOI shows significantly large CO2 adsorption selectivity for CO2/Xe mixture, ZUQPOQ has the largest adsorption selectivity for Xe/N2 mixture.

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Xenon anaesthesia for all, or only a select few?

Cited by 26 publications

References 20 publications

Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics

Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics

Xenon–Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR

Grand Canonical Monte Carlo Modeling of Anesthetic Xe Separation from Exhale Gas Mixtures Using Metal Organic Frameworks

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