Xenon alters right ventricular function

Gesenhues, Jonas; Baumert, J.‐H.; Röhl, Anna Bettina; Pasch, Lauri A.; Schnoor, J.; Coburn, Mark; Rossaint, Rolf

doi:10.1111/j.1399-6576.2008.01696.x

Cited by 12 publications

(7 citation statements)

References 40 publications

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“…Previous studies have estimated msePAP by using the formula of two-thirds sPAP plus one-third dPAP in patients free of pulmonary stenosis. [21][22][23] Our results demonstrate that a single-pressure model is enough, with no need for a dual-pressure model including dPAP. Consistently, studies performed on young subjects with pulmonary stenosis have reported a linear relationship between mean systolic RV pressure and RV peak systolic pressure ( r 5 0.98), with a proportionality constant ranging from 0.60 to 0.73 [24][25][26] .…”

Section: Discussionmentioning

confidence: 74%

“…Previous studies have estimated msePAP by using two-thirds systolic PAP (sPAP) plus one-third diastolic PAP (dPAP) [21][22][23] ; others have suggested a key role for RV systolic pressure. [24][25][26] In the PH and non-PH groups explored at rest, a study using fl uid-fi lled catheters suggested that the oscillatory hydraulic power delivered to the pulmonary circulation by the RV is a constant fraction of total power, 27 and this may suggest a fi xed…”

mentioning

confidence: 99%

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Estimating Right Ventricular Stroke Work and the Pulsatile Work Fraction in Pulmonary Hypertension

Chemla

Castelain

Zhu

et al. 2013

Chest

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Section: Discussionmentioning

confidence: 74%

mentioning

confidence: 99%

Estimating Right Ventricular Stroke Work and the Pulsatile Work Fraction in Pulmonary Hypertension

Chemla

Castelain

Zhu

et al. 2013

Chest

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“…45 With unchanged LV function, a possible cause of a reduction in cardiac output may be reduced right ventricular ejection fraction due to increased pulmonary vascular resistance, which was indeed demonstrated recently in a pig model. 60 Furthermore, xenon can protect myocardium from ischemia and reperfusion damage. Xenon reduced myocardial infarction size in several animal models, including rodents, dogs and pigs.…”

Section: Dovepressmentioning

confidence: 99%

Xenon-based anesthesia: theory and practice

Baumert¹

2009

OAS

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Xenon has been in use as an anesthetic for more than 50 years. Although it exhibits some of the properties of an ideal anesthetic, the technical complexity of xenon equipment and the high cost of the gas have prevented widespread use of xenon anesthesia. The main beneficial features of xenon anesthesia are fast induction and emergence because of low solubility in blood and tissues, along with remarkably stable hemodynamics even in patients with impaired cardiac function. Xenon has proven to be a safe and well-tolerated anesthetic in clinical trials. The primary mechanism by which xenon produces anesthesia-antagonism at the neuronal N-methyl-D-aspartate receptor-and the absence of vasodilating effects distinguish xenon from most other inhaled and intravenous anesthetics. In addition, xenon can protect cells from ischemia-reperfusion damage. This effect was demonstrated in myocardium and neuronal cells as well. Myocardial and cerebral infarction sizes after ischemia can be reduced substantially by xenon, even when administered after the initial insult. Because of its high cost, routine xenon anesthesia may be justified only if it is associated with fewer perioperative complications, shorter duration of hospital stay or significant reduction of perioperative risk. Clinical studies to identify a specific group of patients in which these requirements are met are still lacking.

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“…[1][2][3][4][5][6][7] However, to date these experimentally obtained data have been difficult to verify in clinical settings. The high price of xenon due to its low availability as well as its high minimum alveolar concentration (MAC) value of 63% results in very high costs of a combined xenon/opioid anaesthesia, which limits the use of xenon mainly to clinical trials.…”

Section: Introductionmentioning

confidence: 93%

A practical rule for optimal flows for xenon anaesthesia in a semi-closed anaesthesia circuit

Röhl

Goetzenich

Rossaint

et al. 2010

European Journal of Anaesthesiology

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The current study showed that, by optimization of the electronic regulation of the wash-in procedure for xenon anaesthesia, the consumption of the valuable gas can be reduced by up to 75% in a semi-closed circuit. The additional maintenance of anaesthesia under low flow conditions by coupling the xenon flow to the oxygen consumption is the most effective way to technically reduce the amount of xenon needed for anaesthesia.

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Xenon alters right ventricular function

Abstract: The reduction in CO during xenon anesthesia was partly due to an impairment of the right ventricular function, mainly caused by an increased afterload, without an impairment of systolic ventricular function.

Cited by 12 publications

References 40 publications

Estimating Right Ventricular Stroke Work and the Pulsatile Work Fraction in Pulmonary Hypertension

Estimating Right Ventricular Stroke Work and the Pulsatile Work Fraction in Pulmonary Hypertension

Xenon-based anesthesia: theory and practice

A practical rule for optimal flows for xenon anaesthesia in a semi-closed anaesthesia circuit

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