Xenon-133 inhalation method for regional cerebral blood flow measurements: normal values and test-retest results.

McHenry, Lawrence C.; Merory, John; Bass, Edward; Stump, David A.; Williams, Robert T.; Witcofski, Richard L.; Howard, George; Toole, James F.

doi:10.1161/01.str.9.4.396

Cited by 37 publications

(14 citation statements)

References 17 publications

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“…However, adjustment for pCO 2 was not performed because it is not agreed upon by many authors for 133 Xe CBF measurements when the patient is in resting condition [26][27][28]. Moreover, it has been shown that such a correction could even worsen data distribution [27].…”

Section: Discussionmentioning

confidence: 99%

“…Expired end-tidal pCO 2 was continuously monitored during the examination by a capnograph. All subjects were normocapnic, and ISI values were not corrected for individual pCO 2 values, as suggested by other authors when rCBF examination is performed at rest and in the condition of physiological breathing [26][27][28]. For the present investigation, the absolute ISI value of three probes of the 16-per-hemisphere device (Novo, Hadsund, Denmark), i.e.…”

Section: Patientsmentioning

confidence: 99%

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Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

Nobili¹,

Copello²,

Buffoni³

et al. 2001

Dement Geriatr Cogn Disord

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The present investigation reports the application of regional cerebral blood flow (rCBF; ¹³³Xe method) to prognostic purposes in a consecutive series of 76 patients (mean age 68.4 ± 8.7 years) with probable Alzheimer’s disease (AD; NINCDS-ADRDA criteria). The likelihood that rCBF from a posterior temporal-inferior parietal area in each hemisphere at the first visit may predict timing of achievement of three endpoints (i.e. loss of activity of daily living, ADL, incontinence and death due to end-stage AD) was tested by the ‘lifereg’ procedure of the Statistical Analysis System package. With respect to baseline evaluation, 32 patients lost ADL 20.6 ± 17.4 months later, 31 developed incontinence 27.1 ± 19.0 months later, and 16 patients died after 40.9 ± 23.8 months of follow-up. Baseline rCBF significantly predicted all end-points: the loss of ADL (left hemisphere: p = 0.04; righth hemisphere: p = 0.02), incontinence (p = 0.02 in both hemispheres) and death (p = 0.01 in both hemispheres). Statistical significance was maintained for the loss of ADL and incontinence both in a subgroup of mildly demented patients, in whom death was not considered due to the low number of patients who died, and in a multivariate analysis including patient age, age at onset, sex, duration of illness, Mini-Mental State Examination score and presence of extrapyramidal signs and psychotic symptoms at the first visit. This study shows that rCBF measurement in a posterior temporal-inferior parietal area may give prognostic information on timing of evolution of AD, whenever performed during the course of the disease, and may be utilized both in clinical practice and for social planning.

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Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

Nobili¹,

Copello²,

Buffoni³

et al. 2001

Dement Geriatr Cogn Disord

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show abstract

“…rCBF measured by I-123-IMP was considered as standard in this investigation because rCBF measured by I-123-IMP showed good correlation with that of radioactive microspheres or Xe-133 studies [1,2,3,4,5]. However, spatial resolution of SPECT images is lower than that of MR images, and due to this advantage of unique spatial resolution, new MR sequences are being developed to measure cerebral perfusion along with its anatomic details.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, measurement of regional cerebral blood flow (rCBF) by various brain imaging agents in nuclear medicine techniques has shown good correlation with the gold standard of rCBF measurement either by radioactive microspheres or xenon-133 (Xe-133) studies [1,2,3,4,5]. Measurement of rCBF by iodine-123-iodoamphitamin (I-123-IMP) using auto radiographic (ARG) and modified ARG (table look-up method) have shown very good correlation with the PET, microspheric assessment of cerebral blood flow, and Xe-133 studies [3,6,7,8].…”

mentioning

confidence: 99%

Brain perfusion measured by flow-sensitive alternating inversion recovery (FAIR) and dynamic susceptibility contrast-enhanced magnetic resonance imaging: comparison with nuclear medicine technique

et al. 2001

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The aim of this study was to compare cerebral perfusion images and regional cerebral blood flow (rCBF) of SPECT study with the images and regional intensity of relative cerebral blood flow (CBF) images acquired by contrast-enhanced perfusion MR imaging (pMRI) and flow-sensitive alternating inversion recovery (FAIR). Twelve patients with various cerebral diseases were underwent I-123-IMP SPECT, pMRI, and FAIR studies to measure rCBF. A total of 12 regions of interest (ROI) were created over cerebrum and cerebellum to acquire the corresponding rCBF from I-123-IMP study and regional average signal intensity from CBF images of pMRI and FAIR studies. Left-to-right (L/R) and cerebral-to-cerebellar (CCR) ratios were created from the rCBF of I-123-IMP and signal intensity of CBF images of pMRI and FAIR. Image quality of FAIR was the poorest among all; however, CBF images of pMRI and FAIR images show comparatively decreased intensity at the corresponding site of decreased perfusion on I-123-IMP images. Both FAIR and pMRI images showed high intensity along the sinuses, choroid plexus, and large vessels in sulci. No significant correlation was found among all imaging modalities. But L/R ratio of I-123-IMP showed significant correlation with those of pMRI and FAIR, but for CCR, significant correlation was observed only between I-123-IMP and FAIR. Perfusion images of both pMRI and FAIR may produce images comparable to SPECT study. But to calculate absolute CBF more easy-to-apply and accurate algorithms are needed to overcome the artifacts from large vessels.

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“…Die Ejektionsfraktion war bei allen Normalpersonen > 50%. Nach 5%-iger CO 2 -Inhalation steigt die Hirndurchblutung bei Normalpersonen in der Regel um 10-25% (16,17); in dieser Serie wurden keine neuen CBF-Daten bei CO 2 -Inhalation erhoben.…”

Section: Ergebnisseunclassified

Wird die Hirndurchblutung durch Veränderungen des Herzzeitvolumens beeinträchtigt? Messungen der Hirndurchblutung an Normalpersonen während Volumenbelastung und an Herzschrittmacher- Patienten bei Veränderungen der Stimulationsfrequenz

Hagendorff¹,

Kölsch

Dettmers

et al. 2001

Z Kardiol

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A constant cerebral blood flow (CBF) in the presence of systemic blood pressure changes and cardiac output (CO) alterations during physiological conditions are postulated by the mechanism of cerebral autoregulation. The aim of the present study is the analysis of CBF in pacemaker (PM) patients with unspecific neurological symptoms. CBF was measured in 9 controls and 23 pacemaker patients with 133xenon, CO using Doppler echocardiography or impedance cardiography. Mean and individual CBF in controls remained unchanged when a CO increase of 28% induced by volume overload was observed. In PM patients a mean CO increase of 38% induced by an increase of basic pacing rate caused different effects of CBF. CBF increased or decreased by about 10% or remained constant. In summary, the data suggest an impairment of cerebrovascular function in those patients with concomittant CBF changes due to CO alterations (15/23 approximately equal to 65%). Thus, the analysis of brain perfusion in PM patients with unspecific neurological symptoms is possibly a new diagnostic feature in the future. It can be discussed whether or not indication and optimizing of pacemaker therapy has to be additionally analyzed by determination of endorgan perfusion.

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Xenon-133 inhalation method for regional cerebral blood flow measurements: normal values and test-retest results.

Cited by 37 publications

References 17 publications

Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

Brain perfusion measured by flow-sensitive alternating inversion recovery (FAIR) and dynamic susceptibility contrast-enhanced magnetic resonance imaging: comparison with nuclear medicine technique

Wird die Hirndurchblutung durch Veränderungen des Herzzeitvolumens beeinträchtigt? Messungen der Hirndurchblutung an Normalpersonen während Volumenbelastung und an Herzschrittmacher- Patienten bei Veränderungen der Stimulationsfrequenz

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