Xenogenous Collagen Matrix and/or Enamel Matrix Derivative for Treatment of Localized Gingival Recessions: A Randomized Clinical Trial. Part I: Clinical Outcomes

Abstract

The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.

Root coverage procedures for treating single and multiple recession‐type defects: An updated Cochrane systematic review

“…Forty‐eight studies (reported in 57 papers) were included in the review, with 20 providing data for meta‐analyses. Nine RCTs had their data reported in two articles each (i.e., according to the follow‐up period or type of data (i.e., clinical or patient‐reported outcomes) . Consequently, the papers with a shorter follow‐up period were included under the one study name (e.g., papers with the longer follow‐up), while one article reporting patient‐reported outcomes was included under the name of the clinical outcomes paper .…”

“…Nine RCTs had their data reported in two articles each (i.e., according to the follow‐up period or type of data (i.e., clinical or patient‐reported outcomes) . Consequently, the papers with a shorter follow‐up period were included under the one study name (e.g., papers with the longer follow‐up), while one article reporting patient‐reported outcomes was included under the name of the clinical outcomes paper . Data on the type of study design, location, and country of trial are described in Table .…”

“…Only one study was considered to be at a low overall risk of bias (Figure ) . According to GRADE methods all evidence was considered to be of low to very low quality, mainly for imprecision and inconsistency (see supplementary Appendix in online Journal of Periodontology ).…”

“…ACC, GR change, CAL change and KTW change: ACC related to patient's opinion was reported in 10 RCTs (Table ) Given the heterogeneity of methods/criteria used to assess this outcome and types of procedures compared, formal pooling of data via meta‐analysis was precluded. Of the 48 included trials, 18 evaluating single GR and two multiple GR were included into 11 sets of meta‐analyses (Table ). In addition, data from studies not included in meta‐analyses are presented in supplementary Appendix in online Journal of Periodontology .…”

Biologics‐based regenerative technologies for periodontal soft tissue engineering

“…). A recent randomized clinical trial evaluating the efficacy of several root coverage procedures (CAF alone, CAF + EMD, CAF + collagen matrix and CAF + collagen matrix + EMD) showed that CAF + collagen matrix + EMD was related to the greater percentage of complete root coverage . Similarly, other studies have suggested that combining allografts to EMD may enhance the clinical outcomes, probably due to the scaffold role of the graft material that contributes to the stability of the wound and maintains the space necessary for periodontal regeneration.…”