1988
DOI: 10.1016/s0140-6736(88)91539-5
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Xenogeneic Antibodies and Atopic Disease

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Cited by 7 publications
(3 citation statements)
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“…The immunogenicity of BGG is harder to explain, but may reflect the fact that xenogeneic gamma globulins exhibit special immunological properties as a consequence of their homology with the immunised animals' own antibodies. The strength of the anti-BGG response reported here may have some bearing on our earlier hypothesis that the anti-BGG response in humans consuming cows' milk should include anti-idiotypic antibodies, and that such anti-idiotypic antibodies could play a role in the aetiology of some atopic disease (Collins, 1988).…”
Section: Discussionsupporting
confidence: 54%
“…The immunogenicity of BGG is harder to explain, but may reflect the fact that xenogeneic gamma globulins exhibit special immunological properties as a consequence of their homology with the immunised animals' own antibodies. The strength of the anti-BGG response reported here may have some bearing on our earlier hypothesis that the anti-BGG response in humans consuming cows' milk should include anti-idiotypic antibodies, and that such anti-idiotypic antibodies could play a role in the aetiology of some atopic disease (Collins, 1988).…”
Section: Discussionsupporting
confidence: 54%
“…Another hypothesis relating to development of allergy was recently presented by Collins, suggesting that ingestion of xenogeneic antibodies e.g. from cow's milk and directed against human allergens may prime the immune system (6). Obviously further studies are required to define if sensitization resulting in food intolerance can arise from the exposure of maternal or xenogeneic antibodies.…”
Section: Studies Suggesting the Presence Of Anti-idiotypic Antibodiesmentioning
confidence: 99%
“…Recently, it has been proposed by one of us that xenogeneic antibodies in the human diet may play a role in the aetiology of some atopic diseases [1]. Brief ly, it has been suggested that the antibovine im munoglobulin antibodies which result from human exposure to bovine milk antibodies should include immunoregulatory anti-idiotypic antibodies, and the hypothesis argues that these may interfere with the normal regulation of the production of the IgE iso type for some idiotypes.…”
Section: Introductionmentioning
confidence: 99%