Xenogeneic Antibodies and Atopic Disease

Collins, A M

doi:10.1016/s0140-6736(88)91539-5

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…The immunogenicity of BGG is harder to explain, but may reflect the fact that xenogeneic gamma globulins exhibit special immunological properties as a consequence of their homology with the immunised animals' own antibodies. The strength of the anti-BGG response reported here may have some bearing on our earlier hypothesis that the anti-BGG response in humans consuming cows' milk should include anti-idiotypic antibodies, and that such anti-idiotypic antibodies could play a role in the aetiology of some atopic disease (Collins, 1988).…”

Section: Discussionsupporting

confidence: 54%

Pasteurisation and Homogenisation of Milk Enhances the Immunogenicity of Milk Plasma Proteins in a Rat Model

Feng¹,

Collins²

1999

Food and Agricultural Immunology

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Groups of rats were immunised intraperitoneally with 0.5 ml of raw milk, skim milk, pasteurised milk or pasteurised/homogenised milk. On day 14, animals were boosted with identical preparations, and serum samples were collected on day 28 for the measurement of IgG antibodies directed against milk plasma proteins. Samples were assayed for antibodies to casein, b -lactoglobulin, bovine gamma globulin and bovine serum albumin. Significantly higher concentrations of antibodies of all specificities were detected in the serum of animals immunised with pasteurised/homogenised milk compared with animals immunised with raw or skim milk. Higher concentrations of antibodies were also seen in the group immunised with pasteurised/homogenised milk than the group immunised with pasteurised milk, although significant differences were only seen in the response to casein (p < 0.01). Additional animals were twice immunised with either raw milk fortified with keyhole limpet hemocyanin (KLH), or pasteurised/homogenised milk which had been fortified with KLH prior to processing. Such treatment significantly enhanced the immunogenicity of the KLH (p < 0.05). These results raise the possibility that homogenisation may similarly effect the way in which the human immune system interacts with cows' milk proteins in the gastrointestinal tract, and suggest that milk processing may be an important variable to consider in studies of human allergy to cows' milk proteins.

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Section: Discussionsupporting

confidence: 54%

Pasteurisation and Homogenisation of Milk Enhances the Immunogenicity of Milk Plasma Proteins in a Rat Model

Feng¹,

Collins²

1999

Food and Agricultural Immunology

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“…Another hypothesis relating to development of allergy was recently presented by Collins, suggesting that ingestion of xenogeneic antibodies e.g. from cow's milk and directed against human allergens may prime the immune system (6). Obviously further studies are required to define if sensitization resulting in food intolerance can arise from the exposure of maternal or xenogeneic antibodies.…”

Section: Studies Suggesting the Presence Of Anti-idiotypic Antibodiesmentioning

confidence: 99%

Immunoregulation Mother‐Fetus/Newborn, a RoIe for Anti‐idiotypic Antibodies

Hanson

Carlsson²,

Ekre³

et al. 1989

Acta Paediatrica

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“…Recently, it has been proposed by one of us that xenogeneic antibodies in the human diet may play a role in the aetiology of some atopic diseases [1]. Brief ly, it has been suggested that the antibovine im munoglobulin antibodies which result from human exposure to bovine milk antibodies should include immunoregulatory anti-idiotypic antibodies, and the hypothesis argues that these may interfere with the normal regulation of the production of the IgE iso type for some idiotypes.…”

Section: Introductionmentioning

confidence: 99%

Bovine Milk, including Pasteurised Milk, Contains Antibodies Directed against Allergens of Clinical Importance to Man

Collins

Hosking

et al. 1991

Int Arch Allergy Immunol

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Pasteurised and raw bovine milk and bovine colostrum samples were assayed by enzyme-linked immunoassay for the presence of antibodies directed against a selection of allergens of importance in human atopic disease. Samples were tested for the presence of antibodies directed against or cross-reacting with rye-grass pollen, house dust mites, Aspergillus mould and wheat proteins. Antibodies of each specificity were detected in every sample tested, including all samples of commercial pasteurised milk. The results are discussed with reference to a hypothesis that dietary xenogeneic antibodies may play a role in the emergence of some human atopic disease, and the recent demonstration that oral immunisation with xenogeneic antibodies may lead to the production of anti-immunoglobulin antibodies including anti-idiotypic antibodies.

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Xenogeneic Antibodies and Atopic Disease

Cited by 7 publications

References 44 publications

Pasteurisation and Homogenisation of Milk Enhances the Immunogenicity of Milk Plasma Proteins in a Rat Model

Pasteurisation and Homogenisation of Milk Enhances the Immunogenicity of Milk Plasma Proteins in a Rat Model

Immunoregulation Mother‐Fetus/Newborn, a RoIe for Anti‐idiotypic Antibodies

Bovine Milk, including Pasteurised Milk, Contains Antibodies Directed against Allergens of Clinical Importance to Man

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