Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG)1

Déchaud, H.; Ravard, Claire; Claustrat, Francine; Perrière, Aude Brac de la; Pugeat, Michel

doi:10.1016/s0039-128x(98)00114-7

Cited by 163 publications

(98 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also induce more potent estrogenic metabolites. In addition to these receptor-mediated actions, EDCs may affect synthesis, metabolism, excretion, and binding of endogenous hormones to SHBG, and they have the capacity to inhibit the transcription of androgen-dependent genes [88,89]. Finally, an epigenetic action has been demonstrated [90].…”

Section: Iii-1 Types Of Action Of Environmental Pollutantsmentioning

confidence: 99%

Hypospadias: Interactions between environment and genetics

Kalfa

Philibert

Baskin

et al. 2011

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Iii-1 Types Of Action Of Environmental Pollutantsmentioning

confidence: 99%

Hypospadias: Interactions between environment and genetics

Kalfa

Philibert

Baskin

et al. 2011

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…An interesting application of studies of SHBG-drug interactions has been shown by Miguel-Queralt and Hammond (2008) who reported that SHBG controls the flux of natural or synthetic sex steroids across zebrafish gills, and that this highly specialized functions of SHBG can be disrupted by xenobiotic ligands of SHBG such as ethinyl-estradiol and perhaps others like bisphenol A (Déchaud et al 1998), and this has prompted the development of in silico screening methods for the identification of synthetic chemicals ligands that may act as SHBG ligands (Thorsteinson et al, 2009). It is therefore possible that SHBG could influence the uptake and accumulation of xenobiotic ligands that are present and abundant in water systems, and which could act as potential endocrine disruptors through binding protein interactions in other species, including humans (Déchaud et al 1998).…”

Section: Drug Interactions With Shbg Steroid-binding Sitesmentioning

confidence: 99%

“…It is therefore possible that SHBG could influence the uptake and accumulation of xenobiotic ligands that are present and abundant in water systems, and which could act as potential endocrine disruptors through binding protein interactions in other species, including humans (Déchaud et al 1998). …”

Section: Drug Interactions With Shbg Steroid-binding Sitesmentioning

confidence: 99%

Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome

Pugeat

Nader

Hogeveen

et al. 2010

Molecular and Cellular Endocrinology

Self Cite

105

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. decrease SHBG expression by inducing lipogenesis, which reduces hepatic HNF-4α levels, a transcription factor that play a critical role in controlling the SHBG promoter. Interestingly, diminishing hepatic lipogenesis and free fatty acid liver biosynthesis also appear to be associated with the positive effects of thyroid hormones and PPARγ antagonists on SHBG expression. This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. These important advances in our knowledge of the regulation of SHBG expression in the liver open new approaches for identifying and preventing metabolic disorder associated diseases early in life.

show abstract

“…11,12 Equol and isoflavones have a binding affinity estrogen receptor b. 13,14 Additionally, equol can bind sex hormone-binding globulin 15,16 and 5a-dihydrotestosterone 14 and inhibit the growth of prostate cells in vitro and in vivo. 14,17 Therefore, equol can act as an anti-androgen and inhibit the development of sex hormone-dependent tumors such as breast cancer and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Fujimoto

Tanaka

Hirao

et al. 2008

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Racial differences in the incidence of prostate cancer are manifest worldwide, possibly due to the different dietary habits. To elucidate the relationship between the recent trend of phytoestrogenic isoflavone intake and the increased incidence of prostate cancer in Japan, we conducted an agestratified dietary survey of soybean foods in 102 Japanese healthy men (age range: 10-59 years) and measured the serum isoflavones and equol levels in them and 100 Korean healthy men. The intergroup comparison among the age-stratified groups showed significant differences in the daily intake of genistein and daidzein between the teenager group and the other groups of age^30 years (Po0.05). In the Japanese study, the proportion of equol producers in the teenager group was 10%, being significantly the lowest among the age-stratified groups. The proportions of equol producers in the age-stratified groups from 10 to 49 years were also significantly lower than those in the fifties. The equol non-producers consumed significantly less amounts of isoflavones than the equol producers. In the Korean study, the proportions of equol producers were 45% in the teenager and 40% in the twenties and thirties, being significantly lower than in the forties (80%) and fifties (65%). The decreased intake of isoflavones, low serum level of equol and low incidence of equol production in the young generation may become potential risk factors for prostate cancer not only in Japan but also in Korea in the near future. Elucidating the mechanism of equol production may be promising in developing strategies for chemoprevention against prostate cancer.

show abstract

Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG)1

Cited by 163 publications

References 29 publications

Hypospadias: Interactions between environment and genetics

Hypospadias: Interactions between environment and genetics

Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome

Age-stratified serum levels of isoflavones and proportion of equol producers in Japanese and Korean healthy men

Contact Info

Product

Resources

About