Xenobiotic thiencarbazone-methyl biotransformation investigation by bacteria Streptococcus pneumoniae, Escherichia coli and Streptococcus pyogenes

Ahmad, Khuram Shahzad; Hafeez, Nauma; Gul, Mahwash Mahar; Ali, Daoud; Shaheen, Asma; Aslam, Bilal

doi:10.1007/s13762-020-02948-x

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…The first‐order reaction kinetics is used to match the experimental findings. The reduction in FLP concentration over time was visualized by plotting log[ C t / C o ] against the number of days [19]. The half‐life was calculated by t 1/2 = 0.693/ k , where k represents the log plots' slope.…”

Section: Methodsmentioning

confidence: 99%

Fungal and bacterial assisted bioremediation of environmental toxicant (N‐[2‐[3‐chloro‐5‐(trifluoromethyl)‐2‐pyridinyl] ethyl]‐2‐(trifluoromethyl) benzamide) holding benzamidic genesis elucidating the eco‐friendly strategy

Naeem

Ahmad

2022

J Basic Microbiol

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Fluopyram (FLP) containing benzamidic genesis utilized for seed detoxification and as a foliar application is associated with low profound toxicity in mammals but long-term toxicology investigations have revealed that FLP can stimulate tumor growth. FLP attenuation has been the first time scrutinized employing microorganisms originally identified from soils. Biodegrative assays of four fungal strains; Aspergillus fumigatus (AFu), Aspergillus terreus (AT), Aspergillus flavus (AF), Aspergillus niger (AN), and three bacterial strains:Streptococcus pneumoniae (SP) Streptococcus pyogenes (SPy), and Escherichia coli (EC), were employed. Ten milligrams per liter FLP concentration was made employing separately microbe and analyzed for 35 days. The analytical technique was inclusive of ultraviolet-visible spectrophotometric and high-performance liquid chromatography procedure endeavored to test FLP biodegradation. SP and AT exhibited maximal potentiality to metabolize FLP. HPLC is indicative of several metabolites formations. FLP degradation by AFu, EC, SPy, AN, AF, AT, SP was observed to be 24.2%, 82.7%, 89.8%, 90.7%, 91.3%, 95.4%, and 99.3%, explicating the efficacy of all strains employed in FLP degradation. Current investigations are indicative of significant bioremediation strategies for xenobiotic mitigation. Furthermore, the current examinations are inclusive of the augmentation of biodegradative assays to be utilized on a large scale for efficient environmental management costeffectively and sustainably.

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Section: Methodsmentioning

confidence: 99%

Fungal and bacterial assisted bioremediation of environmental toxicant (N‐[2‐[3‐chloro‐5‐(trifluoromethyl)‐2‐pyridinyl] ethyl]‐2‐(trifluoromethyl) benzamide) holding benzamidic genesis elucidating the eco‐friendly strategy

Naeem

Ahmad

2022

J Basic Microbiol

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“…23,24 The application of triazolinone derivatives in pesticides is mainly focused on the development of herbicides. 25 There are more than 200 patents in the world.…”

Section: Introductionmentioning

confidence: 99%

“…Triazolinone is a nitrogen-containing, five-membered heterocyclic compound. Because of its ultrahigh biological activity and unique mechanism of action, it has attracted the attention of many pharmacologists, especially pesticide researchers. , The application of triazolinone derivatives in pesticides is mainly focused on the development of herbicides . There are more than 200 patents in the world.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Biological Activity of Novel Phenyltriazolinone PPO Inhibitors Containing Five-Membered Heterocycles

Zhao,

Chen,

Luo

et al. 2024

J. Agric. Food Chem.

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Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX, which is a key step in the synthesis of porphyrins in vivo. PPO inhibitors use protoporphyrinogen oxidase as the target and block the biosynthesis process of porphyrin by inhibiting the activity of the enzyme, eventually leading to plant death. In this paper, phenyl triazolinone was used as the parent structure, and the five-membered heterocycle with good herbicidal activity was introduced by using the principle of substructure splicing. According to the principle of bioisosterism, the sulfur atoms on the thiophene ring were replaced with oxygen atoms. Finally, 33 phenyl triazolinones and their derivatives were designed and synthesized, and their characterizations and biological activities were investigated. The in vitro PPO inhibitory activity and greenhouse herbicidal activity of 33 target compounds were determined, and compound D4 with better activity was screened out. The crop safety determination, field weeding effect determination, weeding spectrum determination, and crop metabolism study were carried out. The results showed that compound D4 showed good safety to corn, soybean, wheat, and peanut but poor selectivity to cotton. The field weeding effect of this compound is comparable to that of the commercial herbicide sulfentrazone. The herbicidal spectrum experiment showed that compound D4 had a wide herbicidal spectrum and a good growth inhibition effect on dicotyledonous weeds. Molecular docking results showed that compound D4 forms a hydrogen bond with amino acid residue Arg-98 in the tobacco mitochondria (mtPPO)-active pocket and forms two π–π stacking interactions with Phe-392. This indicates that compound D4 has stronger PPO inhibitory activity. This indicates that compound D4 has wide prospects for development.

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“…This adsorption process controls the dissipation of these herbicides in these soils amended with straw from winter wheat mulch residues and shows that their dissipation is due mainly to a biodegradation process [28]. Some studies have reported microbial degradation via co-metabolism for SMOC transformation in soil [29,30] or via catabolism by different degrading enzymes for sulfonylureas transformation as FORAM in soil [30] or the cleavage of sulfonic acid for TCM [31]. However, the effect these herbicides have on microbial activity during their dissipation in a conservation agricultural system is not well known.…”

Section: Introductionmentioning

confidence: 99%

Changes in Soil Microbial Parameters after Herbicide Application in Soils under Conventional Tillage and Non-Tillage

Douibi,

Carpio,

Rodríguez-Cruz

et al. 2024

Processes

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This study evaluated the changes in microbial activity in the course of time following the joint application of the herbicides S-metolachlor, foramsulfuron, and thiencarbazone-methyl to two soils (S1 and S2) under conventional tillage (CT) and non-tillage (NT) management in field conditions. The biochemical parameters of soil respiration (RES), dehydrogenase activity (DHA), microbial biomass (BIO), and the phospholipid fatty acid (PLFA) profile were determined at 1, 34, and 153 days during herbicide dissipation. In the absence of herbicides, all microbial activity was higher under NT than CT conditions, with higher or similar mean values for S1 compared to S2. A continuous decrease was detected for RES, while DHA and BIO recovered over time. In the presence of herbicides, a greater decrease in all microbial activity was detected, although the changes followed a similar trend to the one recorded without herbicides. In general, a greater decrease was observed in S1 than in S2, possibly due to the higher adsorption and/or lower bioavailability of herbicides in this soil with a higher organic carbon content. The decrease was also greater under CT conditions than under NT conditions because the herbicides can be intercepted by the mulch, with less reaching the soil. These changes involved evolution of the structure of the microbial community.

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Xenobiotic thiencarbazone-methyl biotransformation investigation by bacteria Streptococcus pneumoniae, Escherichia coli and Streptococcus pyogenes

Cited by 6 publications

References 20 publications

Fungal and bacterial assisted bioremediation of environmental toxicant (N‐[2‐[3‐chloro‐5‐(trifluoromethyl)‐2‐pyridinyl] ethyl]‐2‐(trifluoromethyl) benzamide) holding benzamidic genesis elucidating the eco‐friendly strategy

Fungal and bacterial assisted bioremediation of environmental toxicant (N‐[2‐[3‐chloro‐5‐(trifluoromethyl)‐2‐pyridinyl] ethyl]‐2‐(trifluoromethyl) benzamide) holding benzamidic genesis elucidating the eco‐friendly strategy

Design, Synthesis, and Biological Activity of Novel Phenyltriazolinone PPO Inhibitors Containing Five-Membered Heterocycles

Changes in Soil Microbial Parameters after Herbicide Application in Soils under Conventional Tillage and Non-Tillage

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