Xenobiotic Pathway Gene Polymorphisms Associated with Gastric Cancer in High Risk Mizo‐Mongoloid Population, Northeast India

Ghatak, Souvik; Yadav, Ravi Prakash; Lalrohlui, Freda; Chakraborty, Payel; Ghosh, Sudakshina; Das, Madhusudan; Pautu, Jeremy L.; Zohmingthanga, John; Kumar, Nachimuthu Senthil

doi:10.1111/hel.12308

Cited by 19 publications

(14 citation statements)

References 51 publications

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“…Some members under this genus are pathogenic and found to cause peptic ulcers, gastritis, and stomach cancer (Yamaoka 2008 ). This is a significant risk factor for high incidence of stomach cancer among the populace of Mizoram (Ghatak et al 2016 ). Identified bacterial genera possibly involved in fermentation of sa - um were Kouria , Lactobacillus , B. coagulans , Collinsella , and Coprococcus .…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis and the functional profiles of traditional fermented pork fat ‘sa-um’ of Northeast India

et al. 2018

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Fermented pork fat (sa-um) is traditionally and extensively consumed in Northeast Indian region for several decades. However, no scientific reports are available regarding its nutritional value as well as its potential health risks. The objective of this work was essentially the characterization of sa-um using a polyphasic approach, viz., physicochemical, electrospray ionization-mass spectrometry (ESI+-MS) and metagenomic analysis in order to gain an understanding of the nutrient contents and microbial population diversity. On a dry weight basis, about 91% fat, 2% carbohydrate and 0.70% protein were present. ESI+-MS analysis of sa-um revealed the presence of various polar and neutral lipids corresponding to monoacylglyceride, diacylglyceride and triacylglyceride species. The dominant bacterial phyla were Firmicutes, Proteobacteria and Bacteroidetes. A total of 72 bacterial genera were identified, largely abundant with Clostridium species including C. butyricum, C. citroniae, C. methylpentosum, C. perfringens, C. saccharogumia and C. tetani. The imputed functional profiles of bacterial communities were predominantly involved in energy, carbohydrate and amino acid metabolisms. Furthermore, this study deduces the presence of pro-inflammatory molecules as well as antibiotic resistance genes associated with the bacterial families such as Bacillaceae, Bacteroidaceae, Clostridiaceae, Corynebacteriaceae and Enterobacteriaceae which might be a major health concern for the sa-um consuming population.Electronic supplementary materialThe online version of this article (10.1186/s13568-018-0695-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Metagenomic analysis and the functional profiles of traditional fermented pork fat ‘sa-um’ of Northeast India

et al. 2018

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“…An additional 56 articles were excluded, including 56 articles with unavailable data on the genotype frequency of CC, CT, and TT within GSTP1 rs1138272, and 4 articles in which the data were not in HWE. After a quality evaluation, 40 articles (Harris et al, 1998; Saarikoski et al, 1998; Park et al, 1999; Wadelius et al, 1999; Welfare et al, 1999; Marshall et al, 2000; Stanulla et al, 2000; Krajinovic et al, 2002; Wang et al, 2003, 2011; Sorensen et al, 2004; Yang et al, 2004; Garcia-Closas et al, 2005; Landi et al, 2005, 2007; Moore et al, 2005; De Roos et al, 2006; Lira et al, 2006; Marciniak et al, 2006; Jiao et al, 2007; Li et al, 2007, 2010; Murphy et al, 2007; Al-Dayel et al, 2008; Kury et al, 2008; Siraj et al, 2008; Van Emburgh et al, 2008; Zienolddiny et al, 2008; Canova et al, 2009; Northwood et al, 2010; Sainz et al, 2011; Ebrahimkhani et al, 2012; Garcia-Gonzalez et al, 2012; Ibarrola-Villava et al, 2012; Dura et al, 2013; Oskina et al, 2014; Ghatak et al, 2016; De Mattia et al, 2017; Minina et al, 2017; Rajesh et al, 2018) of good quality were included. Finally, we included a total of 43 case-control studies for our quantitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…We removed one case-control study in which the data were not in HWE (Marie-Genica Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk, 2010), and we removed two additional studies (Barnette et al, 2004) because they failed to meet the requirement of reporting the genotype frequency in both the case and control group. Moreover, 17 new articles (Park et al, 1999; Welfare et al, 1999; Marshall et al, 2000; Stanulla et al, 2000; Krajinovic et al, 2002; De Roos et al, 2006; Lira et al, 2006; Li et al, 2007, 2010; Sainz et al, 2011; Garcia-Gonzalez et al, 2012; Dura et al, 2013; Oskina et al, 2014; Ghatak et al, 2016; De Mattia et al, 2017; Minina et al, 2017; Rajesh et al, 2018) were added. Finally, a total of 40 articles were included in our updated meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Association Between the rs1138272 Polymorphism of the GSTP1 Gene and Cancer Susceptibility

Ding

Zhang

et al. 2019

Front. Physiol.

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Background: We obtained conflicting results regarding the relationship between the genetic role of the rs1138272 C/T polymorphism of the GSTP1 (Glutathione S-Transferase pi) gene and the risk of various cancers.Methods: Using the presently available data, a meta-analysis was conducted to comprehensively evaluate the genetic relationship between the GSTP1 rs1138272 polymorphism and cancer susceptibility.Results: A total of 43 studies including 15,688 cases and 17,143 controls were recruited into our quantitative synthesis. In the overall population, we observed an increased risk of overall cancer cases, compared with unrelated controls, in the genetic models of allele T vs. allele C (P-association = 0.007, OR = 1.17), carrier T vs. carrier C (P-association = 0.035, OR = 1.11), TT vs. CC (P-association = 0.002, OR = 1.45), TT vs. CC+CT (P-association = 0.009, OR = 1.42), and CT+TT vs. CC (P-association = 0.027, OR = 1.13). We detected similar positive results within the Asian population. Additionally, there was a significant increase in the incidence of cancer for Africans under all genetic models (all P-association < 0.05, OR > 1). When targeting the Caucasian population, we detected a positive association with the TT vs. CC and TT vs. CC+CT models in the “Colorectal cancer” (P-association < 0.05, OR < 1) and “Head and neck cancer” (P-association < 0.05, OR > 1) subgroups. For the “Lung cancer” subgroup, we observed a slightly increased risk in Caucasians under the models of allele T vs. allele C, carrier T vs. carrier C, CT vs. CC, and CT+TT vs. CC (P-association < 0.05, OR > 1).Conclusion: The TT genotype of the GSTP1 rs1138272 polymorphism is likely related to the susceptibility to overall cancer in the Asian and African populations and, specifically, “Colorectal” and “Head and neck” cancers in the Caucasian population. In addition, the CT genotype of the GSTP1 rs1138272 polymorphism may be linked to the risk of lung cancer in Caucasians. Additional evidence is required to confirm this conclusion.

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“…On the other hand, the SNP in GSTP1 gene resulting in amino acid substitutions at codon 105 (Ile→Val) is also associated with reduced detoxifying activity of the GST enzyme and cancer risk but less studied in premalignant gastric lesions. Many studies showed that the polymorphic variants of GSTT1 , GSTM1 , and GSTP1 genes were associated with increased risk for gastric cancer, especially in the Asian population [ 13 , 21 – 23 ]. However, certain studies performed in the European population sustained that the GST gene polymorphisms are not relevant in gastric cancer [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk

Negovan

Iancu

Moldovan

et al. 2017

BioMed Research International

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The study investigated the possible influence of GSTM1, GSTT1, and GSTP1 gene polymorphisms as predisposing factors for premalignant gastric lesions as well as their interaction with H. pylori infection, gastrotoxic drugs, smoking, and alcohol consumption. In this study, 270 patients with a complet set of gastric biopsies and successfully genotyped were finally included. The GSTM1 gene polymorphism had significant contribution in mild/severe endoscopic lesions (p = 0.01) as well as in premalignant lesions (p = 0.01). The GSTM1 null genotype increased the risk for mucosal defects in H. pylori-negative patients (OR = 2.27, 95% CI: 1.20–4.37) and the risk for premalignant lesions in patients with no alcohol consumption (OR = 2.13, 95% CI: 1.19–3.83). The GSTT1 deleted polymorphism did not significantly increase the risk for premalignant lesions in the absence of gastrotoxic drugs (OR = 1.82, 95% CI: 0.72–4.74). The combined GSTT1T1 and GSTM1 null polymorphisms were borderline correlated with an increased risk for premalignant lesions (OR = 1.72, 95% CI: 1.00–2.97). The wild-type GSTP1 Ile/Ile genotype versus the variant genotypes Ile/Val + Val/Val was significantly associated with a decreased risk of gastric atrophy/intestinal metaplasia (OR = 0.60, 95% CI: 0.37–0.98). In conclusion, the GSTM1 and GSTT1 null genotypes increased the risk for premalignant and endoscopic gastric lesions, modulated by H. pylori, alcohol, or gastrotoxic drug consumption, while the presence of the GSTP1Val allele seemed to reduce the risk for premalignant lesions.

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Xenobiotic Pathway Gene Polymorphisms Associated with Gastric Cancer in High Risk Mizo‐Mongoloid Population, Northeast India

Cited by 19 publications

References 51 publications

Metagenomic analysis and the functional profiles of traditional fermented pork fat ‘sa-um’ of Northeast India

Metagenomic analysis and the functional profiles of traditional fermented pork fat ‘sa-um’ of Northeast India

Comprehensive Analysis of the Association Between the rs1138272 Polymorphism of the GSTP1 Gene and Cancer Susceptibility

The Interaction between GSTT1, GSTM1, and GSTP1 Ile105Val Gene Polymorphisms and Environmental Risk Factors in Premalignant Gastric Lesions Risk

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