Xeno‐ and Auto‐perfusion of Rabbit Kidney.

Abstract

Five rabbit kidneys were perfused with human blood and another five with their own blood in a re‐circulating oxygenated system at 37°C. The flow decreased to 2 ml/min. within 30 min. in all xenoperfusions, while none of the autoperfused had decreased to this level by 60 min. Endothelial damage, exudation, and IgG deposits along the basement membrane of the glomerular capillaries were the discrimininative features of the xenoperfusion. In these experiments, we were unable to demonstrate any major role of platelets in the process leading to decreased blood flow.