XDR-tuberculosis in France: Community transmission due to non-compliance with isolation precautions

Lafeuille, E.; Véziris, Nicolas; Sougakoff, Wladimir; Roure, Francis Nakle de; Dû, Damien Le; Caumes, Éric; Jarlier, Vincent; Aubry, Alexandra; Robert, Jérôme; Bernard, Christine

doi:10.1016/j.medmal.2015.12.008

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…This is to our knowledge the first study to provide quantitative and qualitative information on mismatches between expectations of patients and healthcare workers in DR-TB management during PLOS GLOBAL PUBLIC HEALTH hospitalization. Indeed, the literature contains few case reports on severe incidents leading to serious consequences, such as community transmission due to non-compliance with isolation precautions [20]. These new data take all aspects of hospitalization in TB care into account, including sanatorium stays, hospitalization in the surgery department, etc.…”

Section: Discussionmentioning

confidence: 99%

Patient-centered approach to the management of drug-resistant tuberculosis in France: How far off the mark are we?

Kherabi

Mollo

Gerard

et al. 2022

PLOS Glob Public Health

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Drug-resistant tuberculosis (DR-TB) is a major public health concern worldwide. The prolonged isolation required is a source of challenges for both healthcare workers and patients, especially in high-income countries where DR-TB patients are frequently migrants with vulnerabilities. However, data on the needs of these vulnerable patients are scarce. Our objective was to identify and quantify conflict or inappropriate care situations experienced by both DR-TB patients and healthcare workers. This 10-year retrospective observational study (01/2008 to 10/2018) was conducted in a referral center for resistant tuberculosis management in Paris, France. Sixty-five DR-TB patients were hospitalized during the study period. Their demographic, clinical and social characteristics and any conflict or inappropriate care situations they experienced with healthcare workers while hospitalized were analyzed. Conflict or inappropriate care situations with healthcare workers were reported for 24 patients during their stay (36.9%). Eleven patients (16.9%) had difficulty adhering to respiratory isolation rules, 15 (23.1%) were discharged against medical advice, 9 (13.8%) were excluded from hospital for disciplinary reasons, verbal or physical violence was reported for 7 patients (10.8%), and 4 arrests (6.2%) were made by the police. Conflict situations were reported more often when there was a language barrier (70.8%, p<0.0001). More than one-third of patients with DR-TB in this referral center experienced at least one inappropriate care situation with healthcare workers. This study illustrates the urgent need to promote a patient-centered approach and to respond to the challenges of its practical implementation.

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Section: Discussionmentioning

confidence: 99%

Patient-centered approach to the management of drug-resistant tuberculosis in France: How far off the mark are we?

Kherabi

Mollo

Gerard

et al. 2022

PLOS Glob Public Health

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“…The other three secondary cases identified by genotyping were considered occasional contacts because the retrospective investigation failed to identify any link with the index case; all contacts were born in a different country from the index case and none was born in France. During this study period, no secondary MDR-TB case occurred in patients born in France, in contrast with the case that occurred afterwards, which had already been reported [3].…”

Section: @Erspublicationsmentioning

confidence: 46%

“…Isabelle Dormant 1 , Marie-Odile Dufour 1 , Nora Hocine 1 , Vincent Jarlier 2,3,4 and Nicolas Veziris2,3,4 …”

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Neither genotyping nor contact tracing allow correct understanding of multidrug-resistant tuberculosis transmission

Fournier¹,

Bernard²,

Sougakoff³

et al. 2017

Eur Respir J

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The control of tuberculosis (TB) is challenged by the progressive increase of cases of multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). A recent European study underlined the need for data showing how TB control can be improved in terms of case finding, contact tracing, infection control and treatment to prevent further spread of MDR-/XDR-TB in the EU [1]. In France, the number of MDR-TB cases has markedly increased in recent years [2]. This increase represents a challenge for the control of MDR-TB in the city of Paris, in which one-third of all national MDR-TB cases are concentrated [3]. We performed a study to investigate if this increase of MDR-TB index cases is accompanied by increased transmission. The study was conducted between January 1, 2010 and September 30, 2013, and was a prospective collaborative study between the Centre de Lutte Anti-tuberculeuse de Paris (CLAT75) and the Centre National de Référence des Mycobactéries (NRC).

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“…However, mutations in the KatG gene can induce resistance to INH. The emergence of multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB), and totally drug-resistant TB (TDR-TB) has exacerbated the situation [ 11 , 12 ]. MDR-TB and XDR-TB strains are primarily resistant to the most effective drugs (INH; RIF), bringing the infectious disease back into scientific focus [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Tailoring selective triclosan azo-adducts: Design, synthesis, and anti-mycobacterial evaluation

Shekhar,

Alcaraz,

Seboletswe

et al. 2023

Heliyon

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XDR-tuberculosis in France: Community transmission due to non-compliance with isolation precautions

Cited by 11 publications

References 8 publications

Patient-centered approach to the management of drug-resistant tuberculosis in France: How far off the mark are we?

Patient-centered approach to the management of drug-resistant tuberculosis in France: How far off the mark are we?

Neither genotyping nor contact tracing allow correct understanding of multidrug-resistant tuberculosis transmission

Tailoring selective triclosan azo-adducts: Design, synthesis, and anti-mycobacterial evaluation

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