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Abstract

Objectives: Elevated panel reactive antibody levels have been traditionally associated with increased acute rejection rate and decreased long-term graft survival after kidney transplant. In this study, our objective was to determine patient and allograft outcomes in sensitized kidney transplant recipients with advanced HLA antibody detection and stringent protein sequence epitope analyses.

Knowing the allograft’s destiny

“…Today, with the help of calcineurin inhibitors, we are able to keep the acute rejection rates low (less than 10%) (2). However, we have very few weapons in our armamentarium to identify and influence the chronic process like transplant glomerulopathy, interstitial fibrosis and tubular atrophy (1,3).…”