XC Pulmonary Tissue Reaction following Hytrast Bronchograms

Pulmonary reaction to Hytrast

“…This consists of macrophges, multinucleate giant cells, neutrophil infiltration, bronchiolitis, and fibrosis. This reaction has been seen in the present and previous studies 4iv25 2 (de Bruin, 1965;Greenberg et al, 1964a;Light and 10 Oster, 1964;and Misener et al, 1965). The sequence of changes is not easily followed in surgical specimens, which are usually complicated by other pathological features.…”

“…and Spjut, 1964a), probably a consequence of impaired elimination of particles by the bronchial mucosa. When Hytrast is retained it lies mainly in the alveoli, an observation noted by others (Agee and Shires, 1965;Dutra, 1964;Greenberg et a!., d 1964b;and Rayl and Spjut, 1963). Less frequently, Hytrast is found in bronchi and terminal bron-; chioles.…”

“…Although species differences may occur the changes observed experimentally are similar to those seen in surgical specimens. Greenberg, Spjut, and Hallman (1966) isolated the upper lobe of the dog lung by ligation and studied the pulmonary reactions after exposure of the isolated lobe to aqueous and oily Dionosil, iodized oil, and Hytrast. Within 24 hours Hytrast induced a neutrophil leucocyte response and an acute bronchiolitis.…”