2007
DOI: 10.1016/j.bbrc.2007.05.183
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XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line

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Cited by 59 publications
(43 citation statements)
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“…ER stress pathways can involve Akt-dependent activation of NF-kB (32) and it has been shown that spliced XBP-1 can activate Akt phosphorylation in a zebrafish embryonic cell line (33). We demonstrated that Akt phosphorylation and IkBa degradation, a hallmark of NF-kB pathway activation, were increased in ZZ monocytes compared with MM monocytes (Fig.…”
Section: Akt Is Phosphorylated and Ikba Degraded In Monocytes From Zzsupporting
confidence: 50%
“…ER stress pathways can involve Akt-dependent activation of NF-kB (32) and it has been shown that spliced XBP-1 can activate Akt phosphorylation in a zebrafish embryonic cell line (33). We demonstrated that Akt phosphorylation and IkBa degradation, a hallmark of NF-kB pathway activation, were increased in ZZ monocytes compared with MM monocytes (Fig.…”
Section: Akt Is Phosphorylated and Ikba Degraded In Monocytes From Zzsupporting
confidence: 50%
“…In support of this conclusion, XBP1-deficient cells have reduced AKT phosphorylation without changes in PTEN expression compared with JunB KD cells. XBP1 has been shown to modulate AKT activity in other cell types, 31,42 and XBP1 may directly bind PI3K, facilitating AKT phosphorylation in endothelial cells. 43 JunB may also modulate AKT phosphorylation through a XBP1-dependent improvement of the ER folding capacity and consequent restoration of mTOR or via inhibition of protein phosphatase 2A, two important pathways previously shown to regulate AKT.…”
Section: Discussionmentioning
confidence: 99%
“…24 It can also activate Akt to mediate anti-apoptotic signals. 25 On the other hand, the kinase domain of IRE1 is capable of autophosphorylation, with subsequent downstream activation of cJun N-terminal kinase (JNK). 26 It is this activity of IRE1 that links it to other protein degradation pathways within the cell, such as the autophagy pathway, as JNK phosphorylates Bcl2, allowing the essential autophagy gene, Beclin1, to associate with phosphatidylinositol-3-kinase (PI3K) Class III to trigger autophagy (Figure 1).…”
mentioning
confidence: 99%