XBB.1.16: A new ultimatum for global public health

Hossain, Md. Imam; Kaifa, Fatema Hasan; Bhattacharya, Prosun; Islam, Md. Aminul

doi:10.1097/gh9.0000000000000201

Cited by 1 publication

(1 citation statement)

References 6 publications

(8 reference statements)

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“…The recovery rate reported for XBB.1.16 variant was 98.75% by Ministry’s of India [17]. Till now, there is no evidence which suggests that XBB.1.16 variant is more severe as no noticeable increase in hospitalizations, ICU admissions, or deaths have been reported due to this variant [18]. Study from Maharashtra also reported no significant difference in hospitalization and disease severity for XBB.1.16 as compared to other co-circulating variants [13].…”

Section: Discussionmentioning

confidence: 99%

Genomic surveillance of SARS-CoV-2 and emergence of XBB.1.16 variant in Rajasthan

Sharma,

Gautam,

Sharma

et al. 2024

Preprint

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Background & objectives: Genomic surveillance of positive SARS-CoV-2 samples is important to monitor the genetic changes occurring in virus, this was enhanced after the WHO designation of XBB.1.16 as a variant under monitoring in March 2023. From 5th February till 6th May 2023 all positive SARS-CoV-2 samples were monitored for genetic changes. Methods: A total of 1757 samples having Ct value <25 (for E and ORF gene) from different districts of Rajasthan were processed for Next Generation sequencing (NGS). The FASTA files obtained on sequencing were used for lineage determination using Nextclade and phylogenetic tree construction. Results and discussion: Sequencing and lineage identification was done in 1624 samples. XBB.1.16 was the predominant lineage in 1413(87.0%) cases while rest was other XBB (207, 12.74%) and other lineages (4, 0.2%). Of the 1413 XBB.1.16 cases, 57.47% were males and 42.53% were females. Majority (66.53%) belonged to 19-59 year age. 84.15% of XBB.1.16 cases were infected for the first time. Hospitalization was required in only 2.2% cases and death was reported in 5 (0.35%) patients. Most of the cases were symptomatic and the commonest symptoms were fever, cough and rhinorrhoea. Co-morbidities were present in 414 (29.3%) cases. Enhanced genomic surveillance helped to rapidly identify the spread of XBB variant in Rajasthan. This in turn helped to take control measures to prevent spread of virus and estimate public health risks of the new variant relative to the previously circulating lineages. XBB variant was found to spread rapidly but produced milder disease.

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Section: Discussionmentioning

confidence: 99%