Xantogranuloma do plexo coróideo: relato de caso

Lynch, José Carlos; Moraes, Gloria Patelo de; Duarte, Francisco

doi:10.1590/s0004-282x1988000200011

Arq. Neuro-Psiquiatr.

1988

DOI: 10.1590/s0004-282x1988000200011

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Xantogranuloma do plexo coróideo: relato de caso

José Carlos Lynch

Gloria Patelo de Moraes

Francisco Duarte

Abstract: We report an unusual case of a 30-year-old man who presented blindness and raised intracranial pressure secondary to a huge lateral ventricle xanthogranuloma. Computed tomographic scanning showed a highly calcified hyperdense mass that did not enhance after contrast administration. The mass was subtotally resected via transcallosal approach. The pathogenesis of the choroid plexus xanthogranuloma is discussed.

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Cited by 4 publications

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“…Choroid plexus tumors are infrequent (0.4-1% of central nervous system (CNS) tumors) [1][2][3][4][5] and their immunohistochemical pattern is still controversial, in part due to the paucity of cases available for study, particularly among the malignant variants. Choroid plexus cells are truly epithelial in nature as demonstrated by ultrastructural and immunohistochemical studies [6][7][8][9][10][11][12][13][14][15] .…”

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confidence: 99%

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Barreto

Vassallo

Queiróz

2004

Arq. Neuro-Psiquiatr.

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-Background: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. Method: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of epithelial, neuronal and stromal markers. Results/Conclusions: Relevant histological findings were presence of clear cells in 3/5 papillomas (PP) and 7/8 carcinomas (CA) and all 5 fetal plexuses; rhabdoid cells, desmoplasia and vascular proliferation were found respectively in 3, 4 and 5 cases out of 6 poorly differentiated CA and were absent in PP and well differentiated CA. Pancytokeratin AE1/AE3 was strongly positive in all 13 cases, even in the undifferentiated component of poorly differentiated CA, where reactivity was focal in 3 and diffuse in 3 cases. Low molecular weight cytokeratin (35βH11) was not expressed in any of the 8 CA, but was present in all 5 PP. In 4 of 6 poorly differentiated CA there was reactivity for smooth muscle actin (1A4) in 10 to 30% of the cells. This was true also for one case lacking rhabdoid cells. Laminin was undetectable in all 6 cases of poorly differentiated CA but was present in 4 PP and 2 well differentiated CA. All 5 fetal plexuses expressed GFAP.KEY WORDS: choroid plexus tumors, normal fetal choroid plexus, immunohistochemistry, central nervous system. Papilomas e carcinomas do plexo coróide: estudo histológico e imuno-histoquímico e comparação com plexo coróide fetal normal RESUMO -Contexto: Os tumores do plexo coróide são raros. Os resultados de dados imuno-histoquímicos são escassos e controversos, o mesmo valendo para o plexo coróide normal. Método: Treze casos de tumores do plexo coróide e cinco exemplares de plexo coróide fetal normal foram submetidos a estudo imuno-histoquímico, utilizando-se marcadores para antígenos epiteliais, neurais e estromais. Resultados/Conclusão: Os achados histológicos mais relevantes foram células claras em 3/5 papilomas (PP) e 7/8 carcinomas (CA) e em todos os 5 plexos fetais; células rabdóides, desmoplasia e proliferação vascular foram encontradas, respectivamente, em 3, 4 e 5 casos de 6 CA pouco diferenciados, mas não nos PP e CA bem diferenciados. A pancitoqueratina AE1/AE3 foi fortemente positiva em todos os 13 casos, mesmo no componente indiferenciado do CA pouco diferenciado, em que a reatividade foi focal em 3 casos e difusa em outros 3. A citoqueratina de baixo peso molecular (35βH11) não foi expressa em nenhum dos 8 CA, mas estava presente em todos os 5 PP. Em 4/6 CA pouco diferenciados houve reatividade para actina de músculo liso (1A4) em 10-30% das células. Este achado ocorreu também em um caso sem células rabdóides. Laminina não foi detectada em nenhum dos 6 CA pouco diferenciados, mas estava presente em 4 PP e em 2 CA bem diferenciados. Todos os 5 plexos fetais expressaram GFAP. PALAVRAS-CHAVE: tumores do plexo coróide, plexo coróide fetal normal, imuno-histoquímica, sistema nervoso central.

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mentioning

confidence: 99%

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Barreto

Vassallo

Queiróz

2004

Arq. Neuro-Psiquiatr.

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Xantogranuloma sintomático del ventrículo lateral

et al. 2001

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Multicentric Parenchymal Xanthogranuloma in a Child: Case Report and Review of the Literature

Lesniak¹,

Viglione²,

Weingart³

2002

Neurosurgery

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Intracranial xanthogranulomas are rare, and limited experience with the diagnosis of these lesions has been reported. Although most cases are asymptomatic, this case involves a symptomatic, multicentric, intraparenchymal xanthoma in a pediatric patient. Our review of the literature provides further insights regarding the clinical, radiological, and pathological behavior of these lesions and examines the available treatment strategies.

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Xantogranuloma do plexo coróideo: relato de caso

Cited by 4 publications

References 16 publications

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus

Xantogranuloma sintomático del ventrículo lateral

Multicentric Parenchymal Xanthogranuloma in a Child: Case Report and Review of the Literature

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