Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta

Campos, Marı́a G.; Oropeza, Martha; Villanueva, Teodoro R.; Aguilar, María Isabel; Delgado, Guillermo; Ponce, H.

doi:10.1016/s0024-3205(00)00619-6

Cited by 15 publications

(12 citation statements)

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“…Previous studies evaluated that XNT has antimicrobial [ 15 , 16 , 19 , 22 – 25 ], anti-inflammatory [ 10 , 17 , 26 , 27 ], antioxidant [ 5 , 17 ], antihyperglycemic [ 6 ], antihypertensive [ 21 , 28 ], antiplatelet [ 29 ], nephroprotective and hepatoprotective [ 30 – 32 ], estrogenic and antiestrogenic properties [ 20 , 33 ]. These pharmacological activities are summarized in Table 1 .…”

Section: Historical Application Of Xntmentioning

confidence: 99%

Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Oon

Nallappan

Tee³

et al. 2015

Cancer Cell Int

114

100

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Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required.

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Section: Historical Application Of Xntmentioning

confidence: 99%

Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Oon

Nallappan

Tee³

et al. 2015

Cancer Cell Int

114

100

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“…Iostephane heterophylla (Asteraceae) Antibacterial, vasorelaxation Bisabolene type sesquiterpenoids, diterpenoids and coumarins Aguilar and Delgado (1995), Campos et al (2000), Mata et al (2001) and Aguilar et al (2001) Ligusticum porteri (Apiaceae) Antibacterial Phtalides Delgado et al (1992), Delgado (1996) and Cegiela-Carlioz et al (2005) Piper sanctum (Piperaceae) Antimycobacterial Aporfinic alkaloids, kawapyrones, piperolides, furanes, pyranes, aromatic compounds. Rudolf and Jutta (1982a,b) and Mata et al (2004) Poliomintha longiflora (Lamiaceae)…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and mutagenic activity of Mexican plants used in traditional medicine

Déciga-Campos

Rivero‐Cruz

Arriaga-Alba

et al. 2007

Journal of Ethnopharmacology

182

112

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“…Xanthorrhizol has antitumor properties [2] and also exhibited antibacterial activity against Streptococcus mutans [3]. As well as anticarcinogenic activity, xanthorrhizol suppresses the activity of cyclooxygenase-2 and inductible nitric oxide synthase, which are related to inflammation [4,5]. Moreover, 1 was found to prolong pentobarbital-induced sleeping time.…”

mentioning

confidence: 99%