Xanthophyll Carotenoids Reduce the Dysfunction of Dermal Fibroblasts to Reconstruct the Dermal Matrix Damaged by Carbonylated Proteins

Yamawaki, Yumiko; Mizutani, Taeko; Okano, Yasuaki; Hashimoto, Masaki

doi:10.5650/jos.ess20193

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that polyphenols reduce MMP expression, both in vivo [ 43 ] and in vitro [ 17 ]. A similar reduction in MMP expression was shown by carotenoids in dermal fibroblasts [ 44 ] and in human skin [ 45 , 46 ]. Topical estradiol treatment reduced MMP-1 levels and increased pro-collagen expression in human skin [ 47 ], with similar effects found in murine bones [ 48 ].…”

Section: Discussionsupporting

confidence: 68%

The Protective Effect of Carotenoids, Polyphenols, and Estradiol on Dermal Fibroblasts under Oxidative Stress

et al. 2021

View full text Add to dashboard Cite

Skin ageing is influenced by several factors including environmental exposure and hormonal changes. Reactive oxygen species (ROS), which mediate many of the effects of these factors, induce inflammatory processes in the skin and increase the production of matrix metalloproteinases (MMPs) in dermal fibroblasts, which leads to collagen degradation. Several studies have shown the protective role of estrogens and a diet rich in fruits and vegetables on skin physiology. Previous studies have shown that dietary carotenoids and polyphenols activate the cell’s antioxidant defense system by increasing antioxidant response element/Nrf2 (ARE/Nrf2) transcriptional activity and reducing the inflammatory response. The aim of the current study was to examine the protective effect of such dietary-derived compounds and estradiol on dermal fibroblasts under oxidative stress induced by H2O2. Human dermal fibroblasts were used to study the effect of H2O2 on cell number and apoptosis, MMP-1, and pro-collagen secretion as markers of skin damage. Treatment of cells with H2O2 led to cell death, increased secretion of MMP-1, and decreased pro-collagen secretion. Pre-treatment with tomato and rosemary extracts, and with estradiol, reversed the effects of the oxidative stress. This was associated with a reduction in intracellular ROS levels, probably through the measured increased activity of ARE/Nrf2. Conclusions: This study indicates that carotenoids, polyphenols, and estradiol protect dermal fibroblasts from oxidative stress-induced damage through a reduction in ROS levels.

show abstract

Section: Discussionsupporting

confidence: 68%

The Protective Effect of Carotenoids, Polyphenols, and Estradiol on Dermal Fibroblasts under Oxidative Stress

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Una característica interesante de Haematococcus pluvialis es que los carotenoides de xantofila que contienen análogos de astaxantina se sintetizan en grandes cantidades (Fig. 99) (Yamawaki et al, 2021). (Yamawaki et al, 2021).…”

Section: Fig 98 Estructura De La Fucoxantinaunclassified

Carotenoides

Romero,

Espinoza

2024

View full text Add to dashboard Cite

Con gran satisfacción y entusiasmo se presenta ante la comunidad científica, la presente obra, un libro dedicado a despejar las innumerables dudas respecto al conocimiento de las características, propiedades y métodos de extracción de carotenoides: carotenos y xantófilas. Este libro enfatiza en la importancia que tiene conocer acerca de la estructura, propiedades, biosíntesis, biodisponibilidad en el cuerpo humano, factores que afectan su biodisponibilidad y técnicas de extracción de los carotenoides es para conocer el fundamento de sus funciones esenciales tanto en las plantas como en el ser vivo, en plantas, captan la energía luminosa y actúan como antioxidantes. En el ser vivo al consumir los carotenoides se transforman en vitamina A, micronutriente que interviene en una amplia variedad de funciones fisiológicas, entre las que destaca la función visual, formación y mantenimiento de tejidos blandos, dientes, mucosas y piel, y tiene también un papel clave en el desarrollo fetal, embarazo y lactancia.

show abstract

“…Of those, α-tocopherol and β-carotene applied topically were shown to be effective in some studies. 34 , 45 …”

Section: Therapeutic Perspectivesmentioning

confidence: 99%

A Proteome-Centric View of Ageing, including that of the Skin and Age-Related Diseases: Considerations of a Common Cause and Common Preventative and Curative Interventions

Benoit¹,

Burty-Valin²,

Radman

2023

CCID

View full text Add to dashboard Cite

The proteome comprises all proteins of a cell or organism. To carry their catalytic and structure-related functions, proteins must be correctly folded into their unique native three-dimensional structures. Common oxidative protein damage affects their functionality by impairing their catalytic and interactive specificities. Oxidative damage occurs preferentially to misfolded proteins and fixes the misfolded state. This review provides an overview of the mechanism and consequences of oxidative proteome damage – specifically irreversible protein carbonylation – in relation to ageing, including that of the skin as well as to age-related degeneration and diseases (ARDD) and their mitigation. A literature review of published manuscripts, available from PubMed, focusing on proteome, proteostasis, proteotoxicity, protein carbonylation, related inflammatory diseases, ARDD and the impact of the damaged proteome on ageing. During ageing, proteome damage, especially protein carbonylation, correlates with biological age. Carbonylated proteins form aggregates which can be considered as markers and accelerators of ageing and are common markers of most ARDD. Protein carbonylation leads to general ageing of the organism and organs including the skin and potentially to diseases including Alzheimer and Parkinson disease, diabetes, psoriasis, and skin cancer. Current research is promising and may open new therapeutic approaches and perspectives by targeting proteome protection as an age and ARDD management strategy.

show abstract

Xanthophyll Carotenoids Reduce the Dysfunction of Dermal Fibroblasts to Reconstruct the Dermal Matrix Damaged by Carbonylated Proteins

Cited by 4 publications

References 19 publications

The Protective Effect of Carotenoids, Polyphenols, and Estradiol on Dermal Fibroblasts under Oxidative Stress

The Protective Effect of Carotenoids, Polyphenols, and Estradiol on Dermal Fibroblasts under Oxidative Stress

Carotenoides

A Proteome-Centric View of Ageing, including that of the Skin and Age-Related Diseases: Considerations of a Common Cause and Common Preventative and Curative Interventions

Contact Info

Product

Resources

About