Xanthones from the twigs of Cratoxylum cochinchinense

Bioactive Xanthones from Cratoxylum cochinchinense

“…174-175  C) [19] and 10 (4.8 mg, yellow solid, m.p. 202-203  C) [2] were purified from sub-fraction DFB (12.4 g) by CC with 20% EtOAchexanes. Sub-fraction DFC (7.4 g) was further separated by Sephadex LH-20 with 100% MeOH to give compounds 11 (22.7 mg, yellow solid, m.p.…”

“…Xanthones are an important class of organic compounds that have been isolated from Clusiaceae plants, including Cratoxylum [1][2][3][4], Garcinia [5][6][7] and Hypericum [8][9][10], which are distributed in Southeast Asian countries [1,2]. Xanthones have shown several biological activities, including cytotoxic [11,12], nitric oxide inhibitory [13], antibacterial [14] and anti-HIV-1 protease [11] activities.…”

In vitro Anti-Amebic Activity of Cage Xanthones from Cratoxylum sumatranum Stem Bark Against Entamoeba histolytica

“…The HPLC profile demonstrated that the presence of the methoxy group substituent in the structure of the cage xanthone resulted in differing polarity between the two compounds. The peaks of compounds (1) and 2 Here, we report that compounds (1) and (2), purified from fraction F4 demonstrated strong anti-amebic activity. The results of anti-amebic activity in cell-based and enzymatic assays with cytotoxic properties between compounds (1) and (2) compared to fraction F4 (Table 3).…”

“…1 Plant from the genus Cratoxylum been widely used for ethnomedicinal applications in South East Asia as a treatment of stomachache and diarrhea as well as for the prevention of gastric ulcers. 2,3 Further work was able to isolate xanthone compounds from C. cochinchinense, which was reported to have bioactivity as an antioxidant, anticancer agent and protein inhibitor of tyrosine in diabetes. [4][5][6][7] Preliminary research screening 22 species of plants from Balikpapan Botanical Gardens, Kalimantan Indonesia, demonstrated that dichloromethane extract from the stem bark of Cratoxylum sumatranum (Jack) Bl.…”

A Comprehensive Study on Infrared Spectra of 2-Hydroxyxanthone

“…The parent compound itself does not exist in the natural world, but its derivatives are widely distributed in nature. Naturally occurring xanthones are often separated from various parts of plants, such as Rheedia acuminata bark, [1] Cratoxylum cochinchinense, [2] Gentianuceae, Guttiferae, Anacardiaceae, and metabolic products of some lower fungi, for example, marine-derived fungi [3] and Penicillium raistrickii. [4] Early pharmacological studies have shown that xanthones have a very wide range of pharmacological activities and considerable bioactivity, including antibacterial, analgesic, [5] cytotoxic, [6] febrifuge, [7] antimalaria, [8] and antituberculosis [9] bioactivity.…”