Xanthones from Swertia punctata

Menković, Nebojša; Šavikin-Fodulović, Katarina; Bulatovic, Vanja M.; Aljančić, Ivana; Juranić, Nenad; Macura, Slobodan; Vajs, Vlatka; Milosavljević, Slobodan

doi:10.1016/s0031-9422(02)00231-5

Cited by 39 publications

(19 citation statements)

References 15 publications

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“…Also, HÀC(8) at d(H) 7.23 showed correlations with C(6), C(7), C(8a), and C(9) at d(C) 148.3, 123.4, 118.3, and 176.2, respectively. Further, HÀC(2) at d(H) 7.21 showed cross-peaks with C(1), C(3), C(4), and C(10a) at d(C) 160.7, 165.0, 95.9, and 108.9, and HÀC(4) at d(H) 6.63 was coupled to C(2), C(3), C(4a), C(10a) at d(C) 102.0, 165.0, 158.6, and 108.9, respectively, in agreement with the assignments for ring A [9].…”

supporting

confidence: 84%

A New Xanthone Glycoside and Antioxidant Constituents from the Rhizomes ofSwertia speciosa

Rana

Rawat

2005

C&B

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From the rhizomes of Swertia speciosa, a traditional medicinal plant from the Himalayan region of Uttaranchal (North India), a new constituent, 6-hydroxy-3,5-dimethoxy-1-[(6-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]-9H-xanthen-9-one (8), was isolated, together with nine known compounds. Their structures were elucidated on the basis of chemical, physical, and spectroscopic evidence. Both the acetone and MeOH extracts, as well as the known constituents ursolic acid (5) and 1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (6) exhibited potent antioxidant activities in different biological assays (Table 2).

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confidence: 84%

A New Xanthone Glycoside and Antioxidant Constituents from the Rhizomes ofSwertia speciosa

Rana

Rawat

2005

C&B

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“…However, as for a compound, tetrahydroswertianolin, Hase's report claimed it having extreme antihepatotoxic activity even than the medicine glycyrrhizin. 5) In contrast, we gained a different result that it has only normal activity when compared to the other compounds, such as 5 and 7.…”

Section: Resultsmentioning

confidence: 83%

“…[1][2][3][4] Among them, 5 was a new compound and 11 was isolated for the first time from Swertia genus. 5,6) …”

mentioning

confidence: 99%

Hepatoprotective Activity of the Constituents in Swertia pseudochinensis

Li²,

Sun³

et al. 2005

Biological & Pharmaceutical Bulletin

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A new xanthone derivative was isolated together with other 13 known constituents from a Chinese natural medicine, Swertia pseudochinensis HARA. Their structures were determined based on the spectral and chemical evidences. Furthermore, respective hexane, ethyl acetate, 1-BuOH, MeOH and water extracts of S. pseudochinensis, and purified compounds were respectively evaluated for their hepatoprotective activities against hepatocyte injury induced by CCl 4 . All the extracts and isolated compounds exhibited significant hepatoprotective activities at a dose showing no hepatoxicity.

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“…Several members from this genus, such as S. japonica, S. chirata, S. hookeri, S. macrosperma, S. petiolate, and S. calycina have received considerable attention, as their extracts are known to possess numerous pharmacological properties (Brahmachari et al 2004;Dutt et al 1996;Negi et al 2011;Kakiuchi et al 2014;Peres et al 2000). Extracts from these herbs have been described to possess a characteristic bitter taste, and have potential applications for febrifuge and anthelmintic, tonic, anti-periodic, cathartic, stomachic, asthma, leucorrhoea, analeptic, mitigate inflammation, and relaxing the pregnant uterus (Basnet et al 1994;Cao et al 2013;Jiang et al 2015;Khanal et al 2015;Menkovic et al 2002;Neerja Pant and Jain 2000;Zheng et al 2014).…”

Section: Introductionmentioning

confidence: 99%

High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites

et al. 2016

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Here, we report potential transcripts involved in the biosynthesis of therapeutic metabolites in Swertia japonica , the first report of transcriptome assembly, and characterization of the medicinal plant from Swertia genus. Swertia genus, representing over 170 plant species including herbs such as S. chirata, S. hookeri, S. longifolia, S. japonica, among others, have been used as the traditional medicine in China, India, Korea, and Japan for thousands of years. Due to the lack of genomic and transcriptomic resources, little is known about the molecular basis involved in the biosynthesis of characteristic key bioactive metabolites. Here, we performed deep-transcriptome sequencing for the aerial tissues and the roots of S. japonica, generating over 2 billion raw reads with an average length of 101 bps. Using a combined approach of three popular assemblers, de novo transcriptome assembly for S. japonica was obtained, yielding 81,729 unigenes having an average length of 884 bps and N50 value of 1452 bps, of which 46,963 unigenes were annotated based on the sequence similarity against NCBI-nr protein database. Annotation of transcriptome assembly resulted in the identification of putative genes encoding all enzymes from the key therapeutic metabolite biosynthesis pathways. Transcript abundance analysis, gene ontology enrichment analysis, and KEGG pathway enrichment analysis revealed metabolic processes being up-regulated in the aerial tissues with respect to the roots of S. japonica. We also identified 37 unigenes as potential candidates involved in the glycosylation of bioactive metabolites. Being the first report of transcriptome assembly and annotation for any of the Swertia species, this study will be a valuable resource for future investigations on the biosynthetic pathways of therapeutic metabolites and their regulations.

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Xanthones from Swertia punctata

Cited by 39 publications

References 15 publications

A New Xanthone Glycoside and Antioxidant Constituents from the Rhizomes ofSwertia speciosa

A New Xanthone Glycoside and Antioxidant Constituents from the Rhizomes ofSwertia speciosa

Hepatoprotective Activity of the Constituents in Swertia pseudochinensis

High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites

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