Xanthones from a microfungus of the genus Xylaria

Healy, Peter Conrad; Hocking, Ailsa D.; Tran‐Dinh, Nai; Pitt, John I.; Shivas, R. G.; Mitchell, Jennifer K; Kotiw, Michael; Davis, Rohan A.

doi:10.1016/j.phytochem.2004.07.019

Cited by 72 publications

(49 citation statements)

References 24 publications

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“…Xanthones and partially hydrogenated di-or tetrahydroxanthones are widespread classes of natural products [2] with considerable bioactivity [3][4][5][6][7][8][9][10][11] that occur in fungi, [9,[12][13][14] plants, [15][16][17][18] ferns, [19] and lichens. [20,21] Due to their pronounced toxicity, they are classified as mycotoxins.…”

Section: Introductionmentioning

confidence: 99%

Xanthones and Oxepino[2, 3‐b]chromones from Three Endophytic Fungi

Krohn

Kouam

Kuigoua

et al. 2009

Chemistry A European J

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Three new metabolites, microsphaeropsones A-C (1-3) with a unique oxepino[2,3-b]chromen-6-one (ring-enlarged xanthone) skeleton, were isolated from the endophytic fungus Microsphaeropsis species, co-occurring with their putative biogenetic anthraquinoide precursors citreorosein (4) and emodin (5). From another Microsphaeropsis species, large amounts of fusidienol A (8 a), smaller amounts of emodin (5), the known aromatic xanthones 9 a and 9 b, the new 3,4-dihydrofusidienol A (8 b), and the new aromatic xanthone 9 c were isolated. The endophyte Seimatosporium species produced a new aromatic xanthone, seimatoxanthone A (10), and 3,4-dihydroglobosuxanthone A (12), closely related to alpha-diversolonic ester (13) from Microdiplodia sp.. The structures were determined mainly by extensive 1D and 2D NMR experiments and supported by X-ray single-crystal analysis of 1 and the oxidation product 7. The absolute configurations of the microsphaeropsones A-C (1-3) were established by comparison of the electronic and vibrational circular dichroism (ECD and VCD) spectra of 1 with time-dependent DFT (TDDFT) and DFT calculations by using either the solid-state structures or DFT-optimized geometries as inputs. Preliminary studies indicated that 1, 2, and enone 7 showed antibacterial, fungicidal, and algicidal properties.

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Section: Introductionmentioning

confidence: 99%

Xanthones and Oxepino[2, 3‐b]chromones from Three Endophytic Fungi

Krohn

Kouam

Kuigoua

et al. 2009

Chemistry A European J

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“…The Xylariaceae fungi area rich source of secondary metabolites, including the sesquiterpenexy larenal obtained from Xylaria persicaria, [32] xylactam, a nitrogencontaining compound obtained from fruiting bodies of X. euglossa; and xanthone derivatives obtained from Xylariasp [33] . The xanthones area class of natural products with several pharmacological properties, such as anti-inflammatory, [34] antimicrobial, [35] antioxidants, [36] antifungal [37] and anticancer activities [38] .…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)

Ribeiro¹,

Kamida²,

Almeida³

et al. 2014

Phcog J.

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The Mikania laevigata (Asteraceae) is a Brazilian medicinal plant used to treat respiratory tract diseases. It is produced on a large scale for phytotherapic formulation. No studies on the endophytes of Mikania laevigata have been described in the literature. The endophytic fungi isolated from the leaves of M. laevigata cultivated in a floral garden located in the south region of the Bahia state, Brazil, were investigated. After surface disinfection, the performing the isolation procedure, a total of forty endophytic fungi were obtained and grouped into different morphospecies. The fungi were characterized by molecular sequencing the ITS rDNA regions, and they were identified by comparing the results published Gen Bank sequences.The phylogenetic analyses revealed four major clades of fungi from the sequenced ITS-rDNA regions: Nodulisporium sp. (3 isolates), Hypoxylon sp. (3 isolates), Daldinia sp. (1 isolate) and Xylaria luteostromata (aunique isolate).The Xylariaceae Genus was the dominant group of fungi associated with Mikania laevigata.

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“…The study leadered by Healy et al (2004) resulted on the isolation of xanthones, compounds isolated from endophytic fungi identified as Xylaria sp. The fungus isolated from Glochidion ferdinandi plant, and the metabolites extracted showed important pharmacological activities (Peres & Nagem, 1996;Peres et al, 2000) as for example, anti-inflammatory (Lin et al, 1996), antimicrobial (Malet-Cascon et al, 2003), antioxidants (Minami et al, 1994), antifungical (Rocha et al, 1994) e anticancer properties (Ho et al, 2002).…”

Section: Xylariaceae Metabolites Biological Activitymentioning

confidence: 99%