Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid in mouse tuberculosis models

Abstract

Anti-tuberculosis drug induced hepatotoxicity is the main problem in tuberculosis patients.

The Antibacterial Effect of Humulus lupulus (Hops) against Mycobacterium bovis BCG: A Promising Alternative in the Fight against Bovine Tuberculosis?

“…The authors found no references to studies that investigated the antimicrobial effect of hops effect against Mycoacterium bovis. It was interesting to note from Table 4 that although there are a number of studies which investigated the antimicrobial effect of hops against mycobacteria [11][12][13]25] and as additives in ruminant feedstuffs [31] or for their potential use in methane reduction [6], there were no studies which investigated the use of hops against Mycoacterium bovis.…”

“…The antimicrobial activity of hops has previously been linked to the hop alpha acid humulone, beta acid lupulone and polyphenol xanthohumol [22,25]. Gerhauser (2005) demonstrated the antibacterial activity of xanthohumol against the Gram-positive microorganisms Staphylococcus aureus and Streptococcus mutans along with antiviral and antiparasitic activity [36].…”

“…In our study, there was no observed link between the stated alpha acid content and the antimicrobial activity against Mycobacterium bovis BCG. It may be the case however that the extraction method which is known to lead to isomerisation of such compounds may have a detrimental effect on these components [37] although isohumulone and xanthohumol can be considered important hop bioactive compounds [22,25,28].…”

Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) – A Review

“…85 XN and lupulone showed strong antibacterial properties among the studied compounds. 86 Lou et al 87 investigated the combined effect of XN with isoniazid against mice infected with Mycobacterium tuberculosis. 87 In another study, the antimicrobial activities of hops were investigated against Streptococcus iniae and Vibrio vulnificus.…”

“…86 Lou et al 87 investigated the combined effect of XN with isoniazid against mice infected with Mycobacterium tuberculosis. 87 In another study, the antimicrobial activities of hops were investigated against Streptococcus iniae and Vibrio vulnificus. It has been reported that XN shows the strongest antibacterial property against Streptococcus.…”