Xanthohumol from hop cones (<i>Humulus lupulus</i>L.) prevents ADP-induced platelet reactivity

Luzak, Bogusława; Kassassir, Hassan; Rój, Edward; Stanczyk, Lidia; Watała, Cezary; Golański, Jacek

doi:10.1080/13813455.2016.1247284

Cited by 25 publications

(19 citation statements)

References 30 publications

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“…Our results agree with the cytotoxic effects of beers, showing that Czech beers exhibit a stronger chemopreventive potential compared to other brands of beers as they reached an IC 50 at lower concentrations than other beers. Moreover, although hops has been poorly studied by itself, some of its compounds like flavonols [83] and Xanthohumol [84] have shown anticarcinogenic effects.…”

Section: Resultsmentioning

confidence: 99%

Toxicological Studies of Czech Beers and Their Constituents

Merinas-Amo

García-Zorrilla

et al. 2019

Foods

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Background: Czech beers are unique because they are brewed using specific technology at a particular latitude and for being entirely produced in the area of the Czech Republic. The purpose of this work is the evaluation of toxicological effects of a variety of freeze-dried Czech beers, their raw materials (malts, hops and yeast) and processed-beer (wort, hopped wort and young beer). Methods: In vivo assays to evaluate the safety and protective effects in the Drosophila melanogaster eukaryotic system, and the in vitro evaluations of chemopreventive and DNA damage activity using the HL-60 tumour human cell line were carried out. Results: The safe effects for all the analysed substances and general protective effects against H2O2 were shown both at the individual and genomic level in the Drosophila animal model, with some exceptions. Moreover, all the substances were able to inhibit the tumour cell growth and to induce DNA damage in the HL-60 cells at different levels (proapoptotic, single/double strands breaks and methylation status). Conclusions: The promising effects shown by freeze-dried Czech beers due to their safety, protection against a toxin, chemopreventive potential and the induction of DNA damage in tumour cells, allow the proposition of Czech beer as a beverage with nutraceutic potential.

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Section: Resultsmentioning

confidence: 99%

Toxicological Studies of Czech Beers and Their Constituents

Merinas-Amo

García-Zorrilla

et al. 2019

Foods

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“…Whole blood impedance aggregometry was carried out using a five-channel Roche Diagnostics Multiplate ® analyzer (Munich, Germany), in accordance with the manufacturer’s guidelines. In each whole blood sample, platelet aggregation was monitored for up to 15 min following the addition of ADP (6.4 mmol/L) [27].…”

Section: Methodsmentioning

confidence: 99%

Dual Anticoagulant/Antiplatelet Activity of Polyphenolic Grape Seeds Extract

et al. 2019

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Because of the side-effects of commonly used anti-platelet and anticoagulant drugs, investigations into plant substances with similar activities are very common. Based on our own studies in recent years, we estimate that it is possible to use natural compounds to both inhibit coagulation pathway enzymes and to reduce blood platelets’ activation. As such, in our current study we wanted to verify the anti-platelet and anticoagulant properties of grape seed extract (GSE) using in vitro models. During our analysis, the following parameters were analyzed: Coagulation times, thromboelastometry assays (coagulation time, clot formation time and maximum clot firmness), aggregation of platelets and phosphorylation of vasodilator-stimulated phosphoprotein (VASP). Adenosine diphosphate (ADP)-induced aggregation was lower in GSE 7.5 µg/mL as well as in GSE 15.0 µg/mL. A similar dependence was observed in VASP assays for GSE 7.5 µg/mL and GSE 15 µg/mL. The effect on plasma coagulation tests was distinct only with GSE 15 µg/mL. All of the thromboelastometry variables were statistically significant with 15.0 µg/mL GSE concentration. Our results show, for the first time, the multi-potential effect of grape seed extract on coagulation systems, and clearly suggest that grape seed extract could be considered a promising nutraceutical in the prevention of cardiovascular thrombotic events caused by different mechanisms.

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“…Recent studies demonstrate that standardized polyphenolic plant extracts from various natural sources decrease platelet aggregation, formation of thromboxane A2 and malondialdehyde, as well as inhibit both COX activity (47) and attenuated ADP-induced blood platelet aggregation (48,49).…”

Section: Type Of Thromboxane Controlsmentioning

confidence: 99%

Effect of natural polyphenols on thromboxane levels in children with Crohn’s disease

Koláček¹,

Paduchová²,

Dvořáková³

et al. 2019

BLL

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The aim of this study was to investigate the relationship between thromboxane levels and oxidative stress in children with Crohn´s disease (CD), and examine the effect of natural polyphenolic compounds on thromboxane levels. METHODS: This study involved 14 children suffering from CD and 15 healthy controls. Patients were receiving the polyphenolic extract Pycnogenol for 10 weeks. Plasma levels of the static and dynamic forms of thromboxane B2 as well as their metabolite 11-dehydro thromboxane B2 in urine were determined. RESULTS: In comparison to controls, CD patients had signifi cantly higher levels of the static and dynamic forms of thromboxane B2. Pycnogenol decreased the level of the dynamic form of thromboxane B2 after 10 weeks of administration. CONCLUSIONS: Paediatric Crohn's disease is associated with higher thromboxane levels. Our results indicate that Pycnogenol administration reduces thromboxane levels, which may positively infl uence some clinical symptoms of CD such as thromboembolic episodes (Tab.

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Xanthohumol from hop cones (Humulus lupulusL.) prevents ADP-induced platelet reactivity

Cited by 25 publications

References 30 publications

Toxicological Studies of Czech Beers and Their Constituents

Toxicological Studies of Czech Beers and Their Constituents

Dual Anticoagulant/Antiplatelet Activity of Polyphenolic Grape Seeds Extract

Effect of natural polyphenols on thromboxane levels in children with Crohn’s disease

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