Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice

Costa, Raquel; Rodrigues, Ilda; Guardão, Luísa; Rocha-Rodrigues, Sílvia; Silva, Carolina; Magalhães, José; Ferreira-de-Almeida, Manuel; Negrão, Rita; Soares, Raquel

doi:10.1016/j.jnutbio.2017.03.006

Cited by 52 publications

(69 citation statements)

References 40 publications

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“…4) were identified as the major phytoestrogenic constituents in H. lupulus inflorescences (EFSA, 2009;Kristanc and Kreft, 2016b), compounds which impart an endocrine-disrupting potential to this plant (Kristanc and Kreft, 2016b). Costa et al (2017) demonstrated that the ingestion of 8-prenylnaringenin and xanthohumol could ameliorate diabetic-related metabolic dysfunctions in mice by regulating glucose and lipid pathways. Isoxanthohumol exhibits antiproliferative activity against different human cancer cell lines, including those of the breast, ovarian, prostate, and colon.…”

Section: Monoterpenes Phenylpropanoids and Prenylflavonoidsmentioning

confidence: 99%

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Pinela

Ferreira

2017

Food and Chemical Toxicology

129

111

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A B S T R A C TWild edible plants (WEPs) are part of the cultural and genetic heritage of different regions of the world. In times of famine and scarcity, these sources of nutrients and health-promoting compounds have received high importance mainly in rural and suburban areas. Although currently underutilized, WEPs are still consumed traditionally by different communities and are gaining relevance in today's society. However, these foods lack recognition as significant contributors to the human diet in developed areas. This review describes the nutritional value of WEPs from the North-eastern region of Portugal and points out those containing potentially toxic compounds. Several retrieval strategies are presented with the aim of promoting the (re)use, production, commercialization and conservation of WEPs (wild harvested plants and crop wild relatives), and their importance for social, economic and agro-ecological development is highlighted.

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Section: Monoterpenes Phenylpropanoids and Prenylflavonoidsmentioning

confidence: 99%

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Pinela

Ferreira

2017

Food and Chemical Toxicology

129

111

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“…Independent of the gut microbiota, HE and E2 provided protection against menopause-associated visceral adiposity and liver triglyceride accumulation. Flavonoids in HE, most notably XN, are known modulators of lipid metabolism [69][70][71] and inflammatory cytokines [72][73][74].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hops (Humulus lupulus L.) Extract Supplementation on Weight Gain, Adiposity and Intestinal Function in Ovariectomized Mice

et al. 2019

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Estrogen decline during menopause is associated with altered metabolism, weight gain and increased risk of cardiometabolic diseases. The gut microbiota also plays a role in the development of cardiometabolic dysfunction and is also subject to changes associated with age-related hormone changes. Phytoestrogens are plant-based estrogen mimics that have gained popularity as dietary supplements for the treatment or prevention of menopause-related symptoms. These compounds have the potential to both modulate and be metabolized by the gut microbiota. Hops (Humulus lupulus L.) contain potent phytoestrogen precursors, which rely on microbial biotransformation in the gut to estrogenic forms. We supplemented ovariectomized (OVX) or sham-operated (SHAM) C57BL/6 mice, with oral estradiol (E2), a flavonoid-rich extract from hops, or a placebo carrier oil, to observe effects on adiposity, inflammation, and gut bacteria composition. Hops extract (HE) and E2 protected against increased visceral adiposity and liver triglyceride accumulation in OVX animals. Surprisingly, we found no evidence of OVX having a significant impact on the overall gut bacterial community structure. We did find differences in the abundance of Akkermansia muciniphila, which was lower with HE treatment in the SHAM group relative to OVX E2 treatment and to placebo in the SHAM group.

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“…In recent years, XN ( 1 ), IX ( 2 ) and 8-PN ( 4 ) have been extensively tested for their anti-diabetic properties [ 96 , 134 , 135 ]. Costa et al tested XN ( 1 ) and 8-PN ( 4 ) in a mouse model and found that both compounds have the potential for therapeutic intervention in diabetics type 2 [ 134 ].…”

Section: Phytoestrogensmentioning

confidence: 99%

Flavonoids as Phytoestrogenic Components of Hops and Beer

2020

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The value of hops (Humulus lupulus L.) in beer production has been undisputed for centuries. Hops is rich in humulones and lupulones which gives the characteristic aroma and bitter taste, and preserves this golden drink against growing bacteria and molds. Besides α- and β-acids, the lupulin glands of hop cones excrete prenylated flavonoids, which exhibit a broad spectrum of biological activities and therefore has therapeutic potential in humans. Recently, interest in hops was raised due to hop prenylated flavanones which show extraordinary estrogen activities. The strongest known phytoestrogen so far is 8-prenylnaringenin (8-PN), which along with 6-prenylanaringenin (6-PN), 6,8-diprenylnaringenin (6,8-DPN) and 8-geranylnaringenin (8-GN) are fundamental for the potent estrogen activity of hops. This review provides insight into the unusual hop phytoestrogens and shows numerous health benefits associated with their wide spectrum of biological activities including estrogenic, anticancer, neuropreventive, antinflamatory, and antimicrobial properties, which were intensively studied, and potential applications of these compounds such as, as an alternative to hormone replacement therapy (HRT).

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Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice

Cited by 52 publications

References 40 publications

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society

The Effect of Hops (Humulus lupulus L.) Extract Supplementation on Weight Gain, Adiposity and Intestinal Function in Ovariectomized Mice

Flavonoids as Phytoestrogenic Components of Hops and Beer

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