Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells

Colgate, Emily C.; Miranda, Cristobal L.; Stevens, Jan F.; Bray, Tammy M.; Ho, Emily

doi:10.1016/j.canlet.2006.02.015

Cited by 163 publications

(133 citation statements)

References 30 publications

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“…This is well in accordance with previous findings with xanthohumol in nonhepatic cells. 36,37 Caspases are intracellular cysteine proteases that mediate inflammation and cell death. Caspase-3 in particular is the main effector molecule of apoptosis and a selective inhibitor in the IR process that effectively reduces hepatic IRI.…”

Section: Effect Of Xanthohumol (1) On Expression Of Antiapoptoticmentioning

confidence: 99%

Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury

et al. 2009

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Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-κB activation. To examine the biological relevance of 1, a hepatic ischemia/reperfusion model was chosen as a widely accepted model of oxidative stress generation. The impact of 1 on endogenous antioxidant systems, on the NF-κB signal transduction pathway as well as on apoptotic parameters, and on hepatic tissue damage was evaluated. Compound 1 markedly decreased the level of reactive oxygen species in vitro. Furthermore, levels of enzymatic and nonenzymatic antioxidants were restored after pretreatment in postischemic hepatic tissue, and lipid peroxidation was attenuated. NF-κB activity was reduced in vitro as well as in hepatic tissue after ischemia/reperfusion upon pretreatment with 1. In addition, the phosphorylation of Akt was markedly inhibited. Surprisingly, 1 decreased the expression of the antiapoptotic protein Bcl-X and increased caspase-3 like-activity, a proapoptotic parameter. Moreover, hepatic tissue damage as well as TNF-α levels increased in xanthohumol-pretreated liver tissue after ischemia/reperfusion. In summary, xanthohumol did not protect against ischemia/reperfusion injury in rat liver, despite its antioxidant and NF-κB inhibitory properties.

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Section: Effect Of Xanthohumol (1) On Expression Of Antiapoptoticmentioning

confidence: 99%

Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury

et al. 2009

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“…Recent studies investigating xanthohumol have predominantly focused on the prevention and treatment of cancer (13,14). Studies have demonstrated that xanthohumol inhibits tumor cell growth of colon cancer, prostate cancer, cervical cancer, liver cancer and leukemia cells (15)(16)(17). Therefore, the aim of the present study was to investigate the effect of xanthohumol on the proliferation of human laryngeal squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Wang

Yin

et al. 2016

Oncology Letters

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Abstract. Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and to understand the mechanism of its action. The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, the expression levels of pro-apoptotic proteins, caspase-3, caspase-8, caspase-9, poly ADP ribose polymerase (PARP) p53 and apoptosis-inducing factor (AIF), as well as anti-apoptotic markers, B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1), were analyzed by western blotting. The results revealed that treatment with 40 µM xanthohumol significantly inhibited the proliferation of SCC4 cells. Furthermore, xanthohumol treatment (40 µM) induced SCC4 cell apoptosis, as indicated by the significant increase in activity and expression of caspase-3, caspase-8, caspase-9, PARP, p53 and AIF. By contrast, the protein expression of Bcl-2 and Mcl-1 was significantly decreased following treatment with 40 µM xanthohumol. Taken together, the results of the present study indicated that xanthohumol mediates growth suppression and apoptosis induction, which was mediated via the suppression of Bcl-2 and Mcl-1 and activation of PARP, p53 and AIF signaling pathways. Therefore, future studies that investigate xanthohumol as a potential therapeutic agent for laryngeal squamous cell carcinoma are required.

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“…Up to 70% of all drugs currently used for the treatment of cancer were derived from natural sources. 1 In particular, studies have shown that xanthohumol (XN; 2Ј,4Ј,6Ј,4-tetrahydroxy-3Ј-prenylchalcone), a prenylated chalcone isolated from the hop plant (Humulus lupulus L.), 2 inhibits the growth of different types of human cancer cells (including breast, colon, ovarian, and prostate), leukemia cells, and adipocytes, [3][4][5][6][7][8][9][10][11] and prevents the development of carcinogeninduced preneoplastic lesions in mouse mammary gland organ culture. 5 Researchers also showed that this chalcone inhibits tumor-cell invasion, 12 angiogenesis, 13 and bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB–regulated gene products and potentiation of apoptosis in leukemia cells

Harikumar

Kunnumakkara

Ahn

et al. 2009

Blood

154

125

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Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells

Cited by 163 publications

References 30 publications

Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury

Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia−Reperfusion Injury

Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB–regulated gene products and potentiation of apoptosis in leukemia cells

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