Xanthogranulomes juvéniles disséminés exprimant la protéine S100

Amouri, M.; Gouiaa, Naourez; Chaaben, H.; Masmoudi, A.; Zahaf, A.; Boudawara, Tahia; Turki, H.

doi:10.1016/j.annder.2011.10.408

Cited by 6 publications

(16 citation statements)

References 7 publications

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“…Immunophenotypically, cells express CD14, CD68, CD163, Factor XIIIa, Stabilin-1, and fascin; S100 is a variable positive in less than 20% of the cases; nevertheless, none of these markers are specific for ISJXG,37 and CD1a and langerin are negative. In our case, CD163 and Factor XIIIa were positive, while S100 and CD1a were negative.…”

Section: Discussionmentioning

confidence: 99%

Infantile systemic juvenile xanthogranuloma case with massive liver infiltration

Rodríguez-Velasco¹,

Ortíz-Hidalgo

2019

Autops. Case Rep.

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Infantile systemic juvenile xanthogranuloma (ISJXG) is an uncommon form of juvenile xanthogranuloma, a non-Langerhans cell proliferation of infancy and early childhood. In a small percentage of patients, the visceral involvement—most commonly to the central nervous system, liver, spleen, or lungs—may be associated with severe morbidity, and eventually fatal outcome. Here we describe the clinical and pathological findings of a 28-day-old girl with ISJXG who died with respiratory distress syndrome. She had few cutaneous lesions but massive liver and spleen infiltration; other affected organs were multiple lymph nodes, thoracic parasympathetic nodule, pleura, pancreas, and kidneys. Additional findings were mild pulmonary hypoplasia and bacteremia. Immunohistochemistry on fixed tissues is the standard for diagnosis. Immunophenotype cells express CD14, CD68, CD163, Factor XIIIa, Stabilin-1, and fascin; S100 was positive in less than 20% of the cases; CD1a and langerin were negative. No consistent cytogenetic or molecular genetic defect has been identified. This case demonstrates that the autopsy is a handy tool, because hepatic infiltration, which was not considered clinically, determined a restrictive respiratory impairment. In our opinion, this was the direct cause of death.

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Section: Discussionmentioning

confidence: 99%

Infantile systemic juvenile xanthogranuloma case with massive liver infiltration

Rodríguez-Velasco¹,

Ortíz-Hidalgo

2019

Autops. Case Rep.

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“…One case report from abroad revealed disseminated JXG with S-100 protein positivity without any visceral involvement like our report. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] JXG can be diagnosed by clinico-histological features and confirmed by immunohistochemistry which detects CD68 immunoreactivity with negative staining of CD1a and S-100 protein although few cases of S-100-positive JXG have been reported. [ 3 4 ] Our case was S-100 immunoreactive multiple, cutaneous JXGs with neurofibromatosis type one (NF 1) without any visceral involvement or malignant complication. We are presenting this case due to its rarity.…”

Section: Introductionmentioning

confidence: 99%

Uncommon presentation of a common histiocytic tumor: A rare entity

2015

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Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytic lesion, characterized by benign, usually asymptomatic, self-healing yellowish brown papulonodular lesions of skin and other organs in the absence of metabolic disorder. The cells of origin of JXG are dermal dendrocytic cells. Histopathologically there is dermal infiltration of foamy or non-foamy histiocytes with or without giant cell. Immunohistochemistry shows CD68 positivity with CD1a and S-100 negativity of lesional cells although S-100-positive JXG have been reported. JXG may be associated with neurofibromatosis type one (NF 1) with increased risk of juvenile chronic myelogenous leukemia and other hematological malignancies. Our case was S-100 immunoreactive multiple, cutaneous JXGs with NF 1 without any visceral involvement or malignant complication. We are presenting this case due to its rarity.

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“…Among natural proteins, casein and caseinate are of particular interest thanks to their accessibility, relative inexpensiveness, and total biodegradability. Sodium caseinate (NaCas) consisting of casein monomers and small-scale aggregates obtained aer removal of calcium phosphate, 1 is an interesting candidate for the formation of food packaging lms thanks to its high nutritional, 2 water solubility 3 water holding 4,5 emulsifying, 5,6 lm-forming 7,8 and thermoplastic properties. 9,10 Such interesting physical and techno-functional properties allow the potential use of NaCas as stand-alone edible or biodegradable lms, [11][12][13] edible coatings on food products 14,15 or biodegradable coatings on packaging materials.…”

Section: Introductionmentioning

confidence: 99%

“…10,21 Moreover, caseinate can act as an efficient carrier for bioactive compounds, giving rise to polymeric matrices with interesting physical and functional properties and biological activities. 7 Nowadays, the recovery of valuable compounds from agro-industrial co-products and by-products has been investigated as an efficient tool to enhance the functionality of hydrocolloid-based lms and coatings while at the same time ensuring the sustainability of food preservation in the frame of the circular economy concept. In fact, about 998 million tons of agricultural waste with a huge variety of valuable bioactive compounds end up yearly in landlls or dumped in rivers, causing a signicant pollution problem in absence of an effective management strategy.…”

Section: Introductionmentioning

confidence: 99%