Xanthogranulomatous prostatitis: A rare mimicker of prostate adenocarcinoma

Mukendi, Alain Mwamba; Doherty, Sean; Mohanlal, Reena Dhansukh

doi:10.1002/ccr3.2610

Cited by 6 publications

(12 citation statements)

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“…Of the various forms of inflammation of the prostate, the nonspecific type is the most common, and granulomatous is rare. Xanthogranulomatous inflammation involving the kidneys and gallbladder is common [ 1 , 2 ]. However, xanthogranulomatous prostatitis is rare, with no more than 10 to 15 cases reported to date [ 3 – 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…On pathology, xanthogranulomatous prostatitis typically appears as an accumulation of inflammatory cells, such as lymphocytes, plasma cells, polymorphs, and eosinophils with a large number of foamy macrophages or histiocytes blended with other inflammatory cells [ 3 ]. On multiparametric MRI (mpMRI), findings suggestive of xanthogranulomatous prostatitis can include diffuse changes involving 50% or more of the prostate with infiltration of periprostatic fat or extracapsular extension [ 1 ]. Patient age at presentation can range from the 20s onward; the average age is in the early 60s [ 3 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The presentation is most often of lower urinary tract symptoms or symptoms of a lower UTI, including possible urethral discharge. Prostatic abscesses and rectovesical fistulas have been associated with xanthogranulomatous prostatitis [ 1 , 3 ]. On physical examination, the prostate is usually hard and nodular [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Xanthogranulomatous inflammation involving the kidneys and gallbladder is common [ 1 , 2 ]. However, xanthogranulomatous prostatitis is rare, with no more than 10 to 15 cases reported in the literature [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Xanthogranulomatous Prostatitis: Novel Presentation of a Rare Condition

Joseph

2021

Am J Case Rep

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Patient: Male, 65-year-old Final Diagnosis: Xanthogranulomatous prostatitis Symptoms: Constipation • pelvic pain • tenesmuss • urinary retention Medication: — Clinical Procedure: Biopsy Specialty: General and Internal Medicine • Psychiatry • Urology Objective: Unusual clinical course Background: Xanthogranulomatous prostatitis is rare, with no more than 10 to 15 cases reported to date. The presentation typically includes lower urinary tract or lower urinary tract infection symptoms. The present case report describes a 65-year-old man diagnosed with xanthogranulomatous prostatitis after a prolonged course of atypical symptoms. Symptom remission was achieved with low-dose Cymbalta and 6 weeks of ciprofloxacin. Case Report: A 65-year-old man had a 1-year history of pelvic floor disorder, including treatment-resistant tenesmus and rectal and perineal pain. The patient eventually developed a reduced urinary steam with urinary retention. On digital rectal examination, his prostate was non-tender and had significant firmness on the left side. Magnetic resonance imaging of the prostate with and without contrast showed a Prostate Imaging-Reporting and Data Stem 5 lesion involving the left peripheral zone of the prostate with diffuse enhancement and low signal throughout the gland. Suspicious adjacent lymphadenopathy also was present. The patient’s prostate-specific antigen level was within the normal range at 2.4 ng/mL. All 13 left prostatic biopsy specimens showed acute and chronic inflammatory changes with prominent xanthogranulomatous features and without evidence of necrosis. All of the patient’s symptoms, including pain, resolved after he started taking Cymbalta and completed a 6-week course of ciprofloxacin. Conclusions: The present case report describes an atypical presentation of xanthogranulomatous prostatitis, which started with symptoms of pelvic floor disorder that preceded urinary symptoms by at least 1 year. The patient’s symptoms improved after he started taking Cymbalta and completed a 6-week course of ciprofloxacin, 500 mg twice daily, and without concurrent treatment with an alpha blocker, corticosteroids, or pelvic floor therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Xanthogranulomatous Prostatitis: Novel Presentation of a Rare Condition

Joseph

2021

Am J Case Rep

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“…India 1,8,13,15 and China 12,14,16,18 have reported five cases of XGP each. Other tropical countries such as Pakistan, 6 Morocco, 19 Mexico, 17 Bahrain, 5 Taiwan 9 and South Africa 21 have also reported cases of XGP. In this series, Sri Lanka can further be added to the list, with three cases of XGP.…”

Section: Discussionmentioning

confidence: 99%

Different clinical presentations of xanthogranulomatous prostatitis: A case series and review of the literature

Silva

Sooriyaarchchi

et al. 2020

Journal of Clinical Urology

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Objective: Xanthogranulomatous prostatitis (XGP) is a rare entity that has different clinical presentations. This report of three cases illustrates the diversity of clinical features of XGP, together with a comprehensive literature review. Methods: Three elderly male Sri Lankan patients underwent transurethral resection of the prostate for severe lower urinary tract symptoms. Carcinoma of the prostate was suspected in two patients, and one of them had a very high prostate-specific antigen level (324 ng/mL), suggestive of metastatic prostate carcinoma. The third patient had a clinically benign prostate gland. The histology of all three resected prostate chippings revealed XGP. Results: This case series encompasses two cases of XGP that mimicked carcinoma of the prostate clinically and another case that had benign clinical features. Patients with XGP can have clinical, radiological and serological evidence of advanced prostate carcinoma. Other rare modes of presentation of XGP include prostate abscess and haematospermia. Many concerns of XGP such as aetiology, epidemiology, natural history, risk of malignant transformation and possible treatment options remain unclear due to the paucity of the literature. Conclusions: XGP presents with a variety of benign and malignant clinical features. The possibility of encountering XGP in patients with clinically malignant prostates should not be overlooked.

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Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

Mukendi,

de Heer‐Menlah Phaladi,

Mathye

2024

UroPrecision

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BackgroundRenal cysts are common in clinical practice, but some may harbor rare pathological entities such as mixed epithelial and stromal tumors (MEST). Imaging studies are crucial for accurate diagnosis. While laparoscopic deroofing is an established approach for symptomatic renal cysts, encountering MEST within a cyst is uncommon.Case PresentationWe present the case of a 37‐year‐old female who presented with persistent left flank pain. Imaging revealed a large renal cyst in the lower pole of the left kidney, classified as Bosniak 2. Despite analgesia, the patient's symptoms persisted, leading to a laparoscopic deroofing procedure. Histopathological examination postprocedure revealed a MEST. The patient reported complete resolution of symptoms at the 3‐month follow‐up.ConclusionThis unique case presents the successful identification and surgical management of a MEST masquerading as a lower pole renal cyst through laparoscopic deroofing. It also contributes to the existing literature by highlighting the importance of considering rare pathological entities in the evaluation of renal cysts and the value of laparoscopic techniques in their management.

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Xanthogranulomatous prostatitis: A rare mimicker of prostate adenocarcinoma

Cited by 6 publications

References 6 publications

Xanthogranulomatous Prostatitis: Novel Presentation of a Rare Condition

Xanthogranulomatous Prostatitis: Novel Presentation of a Rare Condition

Different clinical presentations of xanthogranulomatous prostatitis: A case series and review of the literature

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

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