Xanthogranulomatous Pancreatitis Associated with Intraductal Papillary Mucinous Tumor

Kamitani, Takeshi; Nishimiya, Masaki; Takahashi, Naoki; Shida, Yoshitaka; Kanehiro, Hiromichi; Koizuka, Hitohiko

doi:10.2214/ajr.185.3.01850704

Cited by 26 publications

(37 citation statements)

References 5 publications

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“…However, the disease presentation, demographics, and risks are not specific in the previous 17 reports (1,(3)(4)(5)(6)(7)(8)(9)(10). Of the 17 reported cases, xanthogranulomatous pancreatitis was more common (13 of 17) in males.…”

Section: Discussionmentioning

confidence: 98%

“…The locations of lesions are also not specific, including head (5 of 17), body (7 of 17), tail (4 of 17), and uncinated process (1 of 17). At the time of preoperative diagnosis, 11 patients were presumed as a true neoplastic condition, including 6 patients presumed as pancreatic cancer (1,5,8), 4 patients as IPMN (4,6), and one patient as solid pseudopapillary tumor (SPT) (10). The other 6 patients were suggested as having benign condition including three cases of pseudocyst (3,7) and three cases of chronic pancreatitis (9) through clinico-radiological correlation.…”

Section: Discussionmentioning

confidence: 99%

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Xanthogranulomatous Pancreatitis Mimicking a Pancreatic Cancer on CT and MRI: a Case Report and Literature Review

Park

Cho

Bae

et al. 2016

Investig Magn Reson Imaging

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Xanthogranulomatous inflammation is a rare benign condition involving various organs. However, its pancreas involvement is very rare. To the best of our knowledge, only 17 cases have been described in the literature. Interestingly, all reported 17 cases due to various causes underwent surgical resection. Here, we present a case of xanthogranulomatous pancreatitis in a 63-year-old man. He presented with epigastric pain and solid mass mimicking ductal adenocarcinoma in the body and tail of pancreas on magnetic resonance imaging. The patient was diagnosed as xanthogranulomatous pancreatitis via endoscopic ultrasound-guided fine needle aspiration. After that, he was followed up and monitored without any surgical treatment. Here, we show imaging findings and serial image changes of xanthogranulomatous pancreatitis for this case.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous Pancreatitis Mimicking a Pancreatic Cancer on CT and MRI: a Case Report and Literature Review

Park

Cho

Bae

et al. 2016

Investig Magn Reson Imaging

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“…(1). XGP is a rare entity with only a handful of reports in medical literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Out of a total of 4500 cases of chronic cholecystitis diagnosed since 2007 at our institute xanthogranulomatous cholecystitis (XGC) comprised 353 (7.84%).…”

Section: Case Reportmentioning

confidence: 99%

“…Xanthogranulomatous inflammation (XGP) in the pancreas is a rarity but assumes importance as correct diagnosis often is evasive. Of the few reported cases till date (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), nearly all have had normal tumor marker levels. herein, we present the first case of XGP without any associated malignancy demonstrating an elevation of both serum and fluid tumour markers.…”

Section: Introductionmentioning

confidence: 99%

Xanthogranulomatous pancreatitis -a rare case defying clinical, radiological and tumor marker diagnostics with a review of literature

Gaur¹,

Mandal²,

Mahajan³

et al. 2017

TJPATH

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Xanthogranulomatous inflammation of the pancreas is an extremely rare entity mimicking pancreatic neoplasia. Elevation of tumor markers has seldom been reported in xanthogranulomatous inflammation of the pancreas, rendering the diagnosis difficult and highlighting the importance of a meticulous histopathological examination. A 58-year-old male presented with severe abdominal pain and anorexia for six months. A heterogeneously enhancing solid cystic mass was detected in the pancreatic head on contrast enhanced computed tomography. Endoscopic ultrasound guided aspiration yielded fluid showing elevated levels of CA19-9 (12000 IU/ml) and CEA (221ng/ml) with a concordant increase in the serum tumour marker levels (CA 19-9:407 IU/ml; CEA: 70 ng /ml). Clinical, radiological and biochemical evidence favouring malignancy prompted a whipple's procedure. A thorough histopathological examination of the specimen failed to reveal malignancy. Sheets of macrophages (CD 68 +, hAM 56 +), chronic inflammatory cells, fibroblasts and proliferating capillaries replacing most of the pancreatic parenchyma were seen instead, nailing the diagnosis of xanthogranulomatous inflammation of the pancreas. To the best of our knowledge this is the first report of xanthogranulomatous inflammation of the pancreas without associated malignancy displaying an elevation of serum and fluid tumour markers. After seven months of follow up, the patient is asymptomatic and is doing well.

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“…Der weitaus überwiegende Anteil der intraduktalen Neoplasien wird von den intraduktalen papillär muzinösen Neoplasien gestellt, die makroskopisch sichtbare, schleimbildende Proliferationen in den Haupt-und Eine sehr seltene Variante der Entzündung in Assoziation mit einer IPMN ist die xanthogranulomatöse Pankreatitis, die kaum von einer malignen Transformation zu unterscheiden ist [8]. Dabei ist das umgebende Gewebe der IPMN von schaumigen Makrophagen, Lymphozyten und Plasmazellen durchsetzt.…”

Section: Morphologische Varianten Der Ipmnunclassified

Radiologische Diagnostik der intraduktalen papillär muzinösen Neoplasie

Brambs

Juchems

2012

Chirurg

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The intraductal papillary mucinous neoplasm (IPMN) is the most frequent cystic neoplasm of the pancreas. Due to the widespread use of cross-sectional imaging IPMN is being incidentally recognized with increasing frequency. The most common type is branch- duct IPMN which occurs multifocally in about 20-30%. Patients with IPMN may present with symptoms resembling chronic pancreatitis and episodes of acute pancreatitis are increasingly being reported which usually have a mild course. The most important diagnostic technique is contrast-enhanced multidetector computed tomography (MDCT), which most frequently allows the differentiation from other cystic lesions and enables the attribution to branch duct or main duct IPMN. Magnetic resonance imaging (MRI) in combination with magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound are superior in depicting the fine architecture of cystic tumors. Particularly for evaluation of malignant transformation and extent of malignant disease, high resolution imaging is essential. Whereas main duct IPMN is an indication for resection therapy for small and asymptomatic branch duct IPMN periodic surveillance at 6-12 month intervals is recommended.

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Xanthogranulomatous Pancreatitis Associated with Intraductal Papillary Mucinous Tumor

Cited by 26 publications

References 5 publications

Xanthogranulomatous Pancreatitis Mimicking a Pancreatic Cancer on CT and MRI: a Case Report and Literature Review

Xanthogranulomatous Pancreatitis Mimicking a Pancreatic Cancer on CT and MRI: a Case Report and Literature Review

Xanthogranulomatous pancreatitis -a rare case defying clinical, radiological and tumor marker diagnostics with a review of literature

Radiologische Diagnostik der intraduktalen papillär muzinösen Neoplasie

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