Xanthogranulomatous orchitis

Usamentiaga, Elena; Val-Bernal, J. Fernando; Alonso-Bartolomé, Pilar; López-Rasines, Gerardo; Valle, J.I. Del; Calabia, A

doi:10.1016/s0090-4295(98)00331-8

Cited by 15 publications

(15 citation statements)

References 4 publications

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“…1 Microscopically, the lesion consists of a dominant in®ltrate of foamy macrophages interspersed with a minor component of lymphocytes and plasma cells. 2 The aetiology of xanthogranulomatous lesions may include immunological defects, chronic infection, abnormal lipid accumulation, and reduction in chemotactic activities.…”

Section: Introductionmentioning

confidence: 99%

Xanthogranulomatous funiculitis and epididymo-orchitis in a tetraplegic patient

et al. 2000

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Study design: A case report of xanthogranulomatous funiculitis and epididymo-orchitis. Xanthogranulomatous in¯ammation is an uncommon, non-neoplastic process characterised by destruction of tissue, which is replaced by a striking cellular in®ltrate of lipid-laden macrophages. Case report: A 21-year male sustained complete tetraplegia at C-6 level, after a fall in 1998. The neuropathic bladder was managed with an indwelling urethral catheter. He had many unsuccessful trials of micturition. Sixteen months after the cervical injury, he noticed swelling of the left side of the scrotum following removal of a blocked catheter. He was prescribed antibacterial therapy. Four weeks later, physical examination revealed a hard and irregular swelling encompassing the testis, epididymis and spermatic cord. The clinical diagnosis was epididymo-orchitis progressing to pyocele. Through a scrotal incision, the swollen testis, epididymis and diseased segment of the spermatic cord were removed en masse. Histopathology showed extensive areas of necrosis, with xanthogranulomatous in¯ammation in the spermatic cord and to a lesser extent in the testis/epididymis. Conclusion: Repeated episodes of high-pressure urinary re¯ux along the vas deferens during dyssynergic voiding, and subsequent interstitial extravasation of urine together with chronic, low-grade, suppurative infection possibly led to development of xanthogranulomatous in¯ammation in the testis and the epididymis. Since tissue destruction is a feature of xanthogranulomatous in¯ammation, the de®nite and curative treatment is either complete (or, where applicable, partial) excision of the a ected organ in most of the cases. Spinal Cord (2000) 38, 769 ± 772

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Section: Introductionmentioning

confidence: 99%

Xanthogranulomatous funiculitis and epididymo-orchitis in a tetraplegic patient

et al. 2000

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“…Diabetes mellitus has been found in as many as 5 of the 14 reported cases of XGO, including the present one [1,3,4] . Diabetic patients are frequently immunocompromised, and all steps of leukocyte activity, including adherence, chemotaxis, phagocytosis and bactericidal activity are impaired [8] .…”

Section: Discussionmentioning

confidence: 77%

“…Xanthogranulomatous inflammation of the testis is extremely uncommon and, to our knowledge, only 13 cases of XGO/orchiepididymitis have been reported to date [1][2][3][4][5][6][7] . All the cases share the characteristic infiltrate of foamy histiocytes, mixed inflammatory cells and occasional multinucleated giant cells, that constitute the histologic hallmarks of the disease.…”

Section: Discussionmentioning

confidence: 99%

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An Unusual Case of Extensive Xanthogranulomatous Orchitis in a Diabetic Patient

Mannan¹,

Kahvic²,

Sara³

et al. 2009

Med Princ Pract

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Objective: We report an unusual case of extensive xanthogranulomatous orchitis (XGO) in association with poorly controlled diabetes mellitus. Clinical Presentation and Intervention: A 65-year-old Kuwaiti man with poorly controlled diabetes mellitus presented with a painful left testicular swelling of 1 year duration. Testicular tumor markers were normal. Scrotal ultrasonography showed a mass lesion of mixed echotexture, which almost replaced the testicular parenchyma. Left-sided orchiectomy was performed with the clinical diagnosis of testicular neoplasia. Subsequent examination revealed the diagnosis of XGO, and the patient is well 2 years after the operation. Conclusion: Extensive tumorous XGO associated with diabetes mellitus has not been previously reported. We offer this case to highlight the implied role of poorly controlled diabetes mellitus in the pathogenesis of XGO.

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“…To our knowledge, only 19 cases in the male genital system, involving the testis, epididymis and spermatic cord tissue, have been reported in the English literature [1][2][3][4][5][6][7][8]. In the genitourinary system, this process is more frequently seen in the kidney and bladder, and very rarely in the prostatic gland [10,11].…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatöse Epididymitis

Peršec

Bulimbašić

Peršec

et al. 2008

Wien Klin Wochenschr

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Xanthogranulomatous epididymitis is an uncommon non-neoplastic process with destruction of tissue and replacement by striking cellular infiltration of foamy macrophages, dense lymphocytes and plasma cells. We report on a 72-year-old man with a clinical history of inadequately treated arterial hypertension, who presented with a right scrotal mass associated with right scrotal pain for 10 days. Physical examination revealed pyogenic discharge from the hyperemic and edematous scrotum, with normal body temperature. Testicular tumor markers were normal. Ultrasonography (US) of the right testis showed edematous scrotal layers and a heterogeneous area of poorly defined margins within the testis and epididymis. There was minimal hydrocele, and the right funiculus was of normal diameter with no edema or pathologic formation. The progression of clinical findings, inflammatory parameters, US and color Doppler US findings with negative testicular tumor markers indicated surgical treatment. After preoperative treatment, right orchiepididymectomy was performed. Histology confirmed the diagnosis of xanthogranulomatous epididymitis.

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Xanthogranulomatous orchitis

Cited by 15 publications

References 4 publications

Xanthogranulomatous funiculitis and epididymo-orchitis in a tetraplegic patient

Xanthogranulomatous funiculitis and epididymo-orchitis in a tetraplegic patient

An Unusual Case of Extensive Xanthogranulomatous Orchitis in a Diabetic Patient

Xanthogranulomatöse Epididymitis

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