Xanthogranulomatous epididymo-orchitis: A case report with review of the literature

Xanthogranulomatous epididymo-orchitis: A single-institutional case series and systematic review

“…Eight cases reported isolation of Escherichia coli in culture and 3 cases showed the presence of Pseudomonas aeruginosa. [ 1 6 8 9 11 13 17 18 20 25 32 ] Although Gram-negative bacterial infection is common, in one of our cases, Gram-positive Staphylococcus aureus was isolated in culture. Role of Staphylococcus aureus in the pathogenesis of xanthogranulomatous adrenalitis has also been emphasized by one of the authors.…”

“…XGI is a chronic suppurative destructive disease process that involves host factors, stasis, and microbiological organisms, leading to localized proliferation of macrophages. [ 6 8 ] XGI of male genital organs has been rarely reported in medical literature and it may affect testicles, epididymis, spermatic cord, and prostate. [ 2 ] The first case of xanthogranulomatous epididymitis was reported in 1987 by Wiener et al .…”

“…XGEO is a rare disease process with a description of 38 cases reported in 29 articles in medical literature. [ 1 2 6 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 ] The details of demographics and clinical profile of the patients are summarized in Table 1 . Most of these cases have been reported from the Asian continent ( n = 18), followed by Europe ( n = 13), North America ( n = 3), Africa ( n = 2), and 1 case each from South America and Australia.…”

“…[ 2 3 4 5 ] Rarely involved organs include male and female genital tract, wherein testes, prostate, epididymis, ovary, uterus, and fallopian tube may be infiltrated by XGI. [ 6 ] Four cases of xanthogranulomatous epididymitis/orchitis (XGEO) diagnosed at our institute were described. In addition, a systematic review and detailed analysis of XGEO and funiculitis was done.…”

Xanthogranulomatous Orchitis Combined with Contralateral Acute Pyogenic Orchitis: A Rare Case Report

“…A case of yellowish granulomatous orchitis with contralateral acute suppurative orchitis is described here. This is a rare benign testicular disease characterized by necrosis of testicular tissue followed by lipid-filled macrophage infiltration [5][6][7]. he XGO microscopic analysis indicated an accumulation of foamy tissue cells with mixed heterogeneous inflammatory cells, resulting in significant damage and loss of the testicular parenchyma.…”