Xanthoderma: A clinical review

Haught, Justin M.; Patel, Shaily; English, Joseph C.

doi:10.1016/j.jaad.2007.06.011

Cited by 28 publications

(21 citation statements)

References 40 publications

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“…8 Vitamin A has a range of vital systemic functions, but too much of its precursor β-carotene leads to carotenoderma, which tends to occur more frequently in infancy primarily due to increased bioavailability of carotene in their pureed/mashed vegetables and their slower metabolism of carotene than adults. There are a number of non-dietary (secondary) causes of hypercarotenaemia/carotenoderma including metabolic abnormalities, which were not present in our patient, such as hypothyroidism and diabetes mellitus (decreased conversion of carotene to vitamin A), hyperlipidaemia (increased binding sites for carotenoids from raised circulating lipoproteins), renal disease (reduced clearance), liver disease (reduced liver storage and conversion of carotene) 9 and rarely enzyme defect in the metabolism of carotene. 10 Our patient appeared to endure a triad of eating disorder, excessive exercise and work-related stress resulting in hypercarotenaemia/carotenoderma and hypothalamic amenorrhoea.…”

Section: Discussionmentioning

confidence: 77%

Carotenoderma in a young woman of normal body mass index with hypothalamic amenorrhoea: a 2-year follow-up case report

2014

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Hypothalamic amenorrhoea has been shown to be associated with hypercarotenaemia, but no causal link has been established. Many people are unaware of the health implications of carotenoderma. We report on a 36-year-old woman with normal body mass index and with a history of secondary amenorrhoea for 2 years and carotenoderma for 5 years. She had a history of practising a fixed-menu diet of predominantly leafy greens, exercised intensively and had a stressful job. Blood tests confirmed the presence of hypercarotenaemia and hypogonadotrophic hypogonadism. Carotenoderma subsided after 6 months of lifestyle modification, but she remained amenorrhoeic up to 12 months later. Since then, her condition had relapsed up to the time of 2 years of follow-up. We conclude that hypercarotenaemia/carotenoderma and hypothalamic amenorrhoea are manifestations of a constrained lifestyle rather than causally linked. The presence of carotenoderma should alert public individuals and clinicians, especially in primary care, alike for signs of potential health complications including reproductive dysfunction even without weight problems.

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Section: Discussionmentioning

confidence: 77%

Carotenoderma in a young woman of normal body mass index with hypothalamic amenorrhoea: a 2-year follow-up case report

2014

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“…There are other less common causes of both generalized and localized xanthoderma. Jaundice is generalized skin pigmentation due to high serum concentration of bilirubin, but serum levels below 3 mg/dl may present as conjunctival icterus alone ( 1 ). We report here a case of localized yellow pigmentation in the loins, which clinically evoked Grey Turner's sign, a brownish to greenish colouration of the loins.…”

Section: Sirmentioning

confidence: 83%

Localized Abdominal Wall Bile Staining Due To Retroperitoneal Bile Leak

Allegue¹,

Pérez-Pérez²,

Maza³

et al. 2009

Acta Derm Venerol

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“…Other possible etiologies include hemolysis, alcohol ingestion, infectious hepatitis, drug reaction, autoimmunity, gallstones and biliary tract infection. However, all different types of jaundice are characterized by yellow conjunctivae and elevated bilirubin [1]. …”

Section: Discussionmentioning

confidence: 99%

Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric

Horev

Ramot

Klapholz

2015

Drug Saf - Case Rep

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Yellow discoloration of the skin may be caused by several etiologies, including jaundice, hypervitaminosis, drug reaction or chemical exposure. Herein we describe a 68-year-old woman with a history of breast and thyroid carcinoma, presenting with a yellow discoloration of her soles, after ingestion of one capsule a day of turmeric root extract (Bluebonnet Turmeric Root, 500 mg, Vcap), taken for its anti-cancer properties, for 4 months. After drug cessation, the yellow hue disappeared completely. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s symptom and her use of the drug. Curcumin, a mixture of diferuloymethane derivatives known as curcuminoids, is a yellow pigment present in the spice turmeric. Topical application of curcumin to the human skin is joined by orange-yellow discoloration. To the best of our knowledge, yellow skin discoloration after oral intake of turmeric is not mentioned in the medical literature.

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Xanthoderma: A clinical review

Cited by 28 publications

References 40 publications

Carotenoderma in a young woman of normal body mass index with hypothalamic amenorrhoea: a 2-year follow-up case report

Carotenoderma in a young woman of normal body mass index with hypothalamic amenorrhoea: a 2-year follow-up case report

Localized Abdominal Wall Bile Staining Due To Retroperitoneal Bile Leak

Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of Turmeric

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