Xanthine oxidase levels in human brain tumors

Kökoğlu, Emine; Belce, Ahmet; Özyurt, Emin; Tepeler, Z.

doi:10.1016/0304-3835(90)90262-v

Cited by 50 publications

(27 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results are conflicting concerning the xanthine oxidase activity in cancerous tissue. Some researchers have suggested that the activity of xanthine oxidase increases in cancerous tissue [13], whereas others have claimed that it decreases [7,18]. This disparity may be due to the different histological types of cancerous tissue studied.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Xanthine Oxidase in Human Tissues.

Moriwaki

Yamamoto

Yamaguchi

et al. 1996

Acta Histochem. Cytochem

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Xanthine Oxidase in Human Tissues.

Moriwaki

Yamamoto

Yamaguchi

et al. 1996

Acta Histochem. Cytochem

View full text Add to dashboard Cite

“…Oxidative stress, free oxygen radicals and lipid peroxidation are thought to damage the cell membranes and take part in oncogenesis. 20,21 Pu et al studied the activities of antioxidant enzymes and showed that Cu(copper), Zn-SOD (superoxide dismutase) and Mn-SOD (manganese-superoxide dismutase) were decreased (in descending order) in meningiomas, low grade astrocytomas, high grade astrocytomas and medulloblastomas. 22 Lipid peroxidation end products and scavenging system elements have been thought to play a role in oncogenesis.…”

Section: Statistical Analysesmentioning

confidence: 97%

Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas

Kafadar

Ergen

Zeybek

et al. 2006

Cell Biochem. Funct.

View full text Add to dashboard Cite

The purpose of this study was to demonstrate the relationship between serum PON1 activity and PON 192 polymorphism in brain tumours. The distribution of PON 192 polymorphism in 42 high grade gliomas and 42 meningiomas were determined by polymerase chain reaction--based restriction fragment length polymorphism analysis and compared with 50 healthy control subjects. Serum paraoxonase1 activities were also measured and compared in the same population. We found that in both tumour groups serum PON1 activity was significantly lower than the control group (p < 0.001), but did not differ between meningiomas and high grade gliomas. There was no significant difference either in distribution of the AA, AB and BB genotypes or in the allelic frequencies, between the patient group and control subjects (p > 0.05). Our results suggest that serum PON1 as a part of the lipid peroxidation scavenging systems might be involved in the tumourigenesis of brain tumours.

show abstract

“…XO-derived superoxide anion has been linked to reperfusion injury and edema (143), as well as changes in vascular permeability (144), and limitation of superoxide anion generation by this enzymatic pathway would be beneficial in the case of ischemia. Furthermore, serum XO levels are increased in hepatitis and mild hepatotoxicity (145); they are also significantly increased in brain tumor tissues as compared with normal brain tissue (146), and the degree of brain edema and injury is dependent on the level of XO. Gout is also caused by the deposition of urate crystals, a by-product of the XO-catalyzed reaction, in the joints.…”

Section: Xanthine Oxidasementioning

confidence: 99%