Xanthine Oxidase Inhibitory Activity of Hungarian Wild-Growing Mushrooms

Ványolós, Attila; Orbán-Gyapai, Orsolya; Hohmann, Judit

doi:10.1002/ptr.5115

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…As well as the above species XO inhibitory activity of aqueous and organic (n-hexane, chloroform, and 50% methanol) extracts of 47 wild-growing mushrooms native to Hungary have been reported. Among the 47 species, Hypholoma fasciculare (IC50= 67.76 ± 11.05 μg/ml), Suillus grevillei (IC50= 13.28 ± 1.58 μg/ml), and Tricholoma populinum (IC50= 85.08 ± 15.02 μg/ml) were exhibited high inhibitory activity [60].…”

Section: Mushroomsmentioning

confidence: 99%

Exploration of Microorganisms as a Potential Source of Xanthine Oxidase Inhibitors: An Updated Review

Batchu

Surapaneni

2018

Int J Pharm Pharm Sci

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Nowadays the prevalence of hyperuricemia has significantly increased in which serum uric acid levels are exceeding the normal range. Gout is the predominant clinical implication of the hyperuricemia, but many clinical investigations have confirmed that hyperuricemia is an independent risk factor for cardiovascular disease (CVD), hypertension, diabetes, and many other diseases. The xanthine oxidase (XO) converts hypoxanthine to xanthine and ultimately to uric acid, and the irreversibly accumulated uric acid causes hyperuricemia associated with gout. Hence specific and selective xanthine oxidase inhibitors (XOI) are potentially powerful tools for inactivating target XO in the pathogenic process of hyperuricemia (Gout). The objective of the current study was to overview the various XOI isolated from the microorganisms. Microorganisms have been employed for several decades for the large-scale production of a variety of bio-chemicals ranging from alcohol to antibiotics and as well as enzyme inhibitors. Currently available XOI (allopurinol and febuxostat) for the treatment of gout have been exhibiting serious side effects. Thus, there is a need to search for new molecules to treat hyperuricemia and its associated disorders. At present, microbes have been unexplored in the development of successful products for the management of XO-related diseases. Hence, the present review focused on novel XOI produced from various microbial species such as Actinobacteria, lichens, bacteria, endophytic fungi and mushrooms, which can be expected to play an important role in the ongoing transition from the empirical screening to the real rational drug design.

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Section: Mushroomsmentioning

confidence: 99%

Exploration of Microorganisms as a Potential Source of Xanthine Oxidase Inhibitors: An Updated Review

Batchu

Surapaneni

2018

Int J Pharm Pharm Sci

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“…Naematolin, a caryophyllane derivative with cytotoxic activity, was isolated from cultures of H. lateritium [6]. Attempts have been made to characterize the possible mechanism of action behind the antitumor and anti-inflammatory effects of H. lateritium extracts [7,8], as well as to explore the antimicrobial, antioxidant, and xanthine oxidase inhibitory properties of this species [9,10,11]. The current study was performed to identify the major secondary metabolites of H. lateritium and characterize their toxicity in bdelloid rotifer assays.…”

Section: Introductionmentioning

confidence: 99%

Triterpenes from the Mushroom Hypholoma lateritium: Isolation, Structure Determination and Investigation in Bdelloid Rotifer Assays

et al. 2019

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Twelve compounds (1–12) were isolated from the methanol extract of brick cap mushroom (Hypholoma lateritium (Schaeff.) P. Kumm.). The structures of the compounds were elucidated using extensive spectroscopic analyses, including NMR and MS measurements. Lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (1) and 8-hydroxy-13-oxo-9E,11E-octa-decadienoic acid (2) were identified as new natural products, together with ten known compounds, from which 3β-hydroxyergosta-7,22-diene (4), demethylincisterol A2 (5), cerevisterol (6), 3β-O-glucopyranosyl-5,8-epidioxyergosta-6,22-diene (7), fasciculol E (9), and uridine (12) were identified in this species for the first time. The isolated triterpenes (1, 3–11) were investigated for their toxicity in vivo using bdelloid rotifer assays. Most of the examined steroids in general showed low toxicity, although the effects of the compounds varied in a wider range from the non-toxic lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (1) to the significantly toxic cerevisterol (6), with substantial dependence in some cases on the presence of nutrient in the experimental environment.

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“…As a continuation of our screening programme relating to plants and bioactive natural compounds in the flora of the Carpathian Basin (Réthy et al, 2007;Csupor-Löffler et al, 2009;Lajter et al, 2013;Ványolós et al, 2014), the present work describes for the first time a systematic in vitro XO inhibitory assay of extracts prepared from 27 species belonging in the Fallopia, Rumex, Polygonum, Persicaria and Oxyria genera of the Polygonaceae family occurring in the Carpathian Basin.…”

Section: Introductionmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species

et al. 2014

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The xanthine oxidase (XO)-inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) and P. viviparum demonstrated the highest XO-inhibitory activity (> 85% inhibition) at 400 µg/mL. The IC 50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella, are considered worthy of activity-guided phytochemical investigations.

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Xanthine Oxidase Inhibitory Activity of Hungarian Wild-Growing Mushrooms

Cited by 13 publications

References 28 publications

Exploration of Microorganisms as a Potential Source of Xanthine Oxidase Inhibitors: An Updated Review

Exploration of Microorganisms as a Potential Source of Xanthine Oxidase Inhibitors: An Updated Review

Triterpenes from the Mushroom Hypholoma lateritium: Isolation, Structure Determination and Investigation in Bdelloid Rotifer Assays

Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species

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