Xanthine and Aldehyde Oxidase Inhibitory Activities, and Antihyperuricemic Effects of Fermented Smilax china L. Leaf Extracts and Fractions

S, Lee; Lee, Ye-Kyung; Kim, Soon-Dong; Cheng, Jinhua; Yang, Seung Hwan; Suh, Joo‐Won

doi:10.3839/jabc.2014.009

Cited by 4 publications

(1 citation statement)

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“…Recently, there have been many studies discussing the use of Smilax china L. leaves. These studies reported that they have antioxidant, antimicrobial [ 21 ], antidiabetic [ 27 ], and anti-hyperuricemia effects [ 28 ] owing to the presence of significant amounts of polyphenols [ 29 ] such as rutin, kaempferin, and kaempferitrin [ 30 ]. However, the stems of Smilax china L., including its thorny vines that affect the growth of other plants, are usually discarded as a waste.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

2017

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The search for natural inhibitors with anti-diabetes properties has gained increasing attention. Among four selected Smilacaceae family plants, Smilax china L. stems (SCS) showed significant in vitro anti-glycation and rat lens aldose reductase inhibitory activities. Bioactivity-guided isolation was performed with SCS and four solvent fractions were obtained, which in turn yielded 10 compounds, including one phenolic acid, three chlorogenic acids, four flavonoids, one stilbene, and one phenylpropanoid glycoside; their structures were elucidated using nuclear magnetic resonance and mass spectrometry. All solvent fractions, isolated compounds, and stem extracts from plants sourced from six different provinces of South Korea were next tested for their inhibitory effects against advanced glycation end products, as well as aldose reductase. α-Glucosidase, and lipase assays were also performed on the fractions and compounds. Since compounds 3, 4, 6, and 8 appeared to be the superior inhibitors among the tested compounds, a comparative study was performed via high-performance liquid chromatography with photodiode array detection using a self-developed analysis method to confirm the relationship between the quantity and bioactivity of the compounds in each extract. The findings of this study demonstrate the potent therapeutic efficacy of SCS and its potential use as a cost-effective natural alternative medicine against type 2 diabetes and its complications.

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Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

2017

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Hepatotoxicity Reducing Effect of Ethanol Extracts from Fermented Youngia denticulata Houtt Kitamura in Ethanol-treated Rats

Kim¹,

Lee²

2016

EASDL

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Medicinal Plants for Gout Treatment

Tung

2023

Exploring Complementary and Alternative Medicinal Products in Disease Therapy

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Gout is a complex form of arthritis characterized by sudden, severe attacks of pain, swelling, redness, and tenderness in the joints. Gout is a type of inflammatory arthritis that is triggered by the crystallization of uric acid within the joints and is often associated with hyperuricemia. Natural products offer many options to reduce the progress and symptoms of diseases, including gout. Natural compound structures including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory, antioxidant, and XO activities. In this chapter, the author presents medicinal plants and isolated compounds that are used to prevent and reduce signals of the pathogenesis of gout disease.

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Xanthine and Aldehyde Oxidase Inhibitory Activities, and Antihyperuricemic Effects of Fermented Smilax china L. Leaf Extracts and Fractions

Cited by 4 publications

References 45 publications

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

Chemical Constituents of Smilax china L. Stems and Their Inhibitory Activities against Glycation, Aldose Reductase, α-Glucosidase, and Lipase

Hepatotoxicity Reducing Effect of Ethanol Extracts from Fermented Youngia denticulata Houtt Kitamura in Ethanol-treated Rats

Medicinal Plants for Gout Treatment

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