Xanthelasma Palpebrarum-clinical and biochemical profile in a tertiary care hospital of Delhi

Jain, Abhishek; Goyal, Parul; Nigam, P. K.; Gurbaksh, H.; Sharma, R. C.

doi:10.1007/bf02913335

Cited by 42 publications

(88 citation statements)

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“…1). This is in concordance with previous studies by Sankar SP, Samuel P, Jain et al, Gangopadadhya et al, Epstein et al and Pedace et al [6][7][8][9][10] Cosmetic concern might be a reason for female preponderance in OPD.…”

Section: Resultssupporting

confidence: 93%

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Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

2020

IJN

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Introduction: Xanthelasma palpebrum (XP) is a disorder of lipid metabolism that usually presents as bilateral and symmetrical, soft velvety papules and plaques around the eyelids. Though various factors contribute to its etiology, a strong association with lipid metabolism is proposed. Usually seen in middle age people, its main concern is cosmetic appearance. Objective: 1. To evaluate the lipid profile, glycemic levels, Body Mass Index (BMI) in patients with Xanthelasma palpebrum. 2. To find the association between parameters like age, sex and comorbid illness with Xanthelasma palpebrum. Materials and Methods: This prospective study included 42 clinically diagnosed patients with Xanthelasma Palpebrarum and 95 subjects in control group with non-inflammatory skin disorders. Levels of serum triglyceride, cholesterol, HDL, LDL, VLDL, blood sugar -fasting and post prandial were determined in all cases along with body mass index and blood pressure. These parameters were compared in both groups and association with XP was analysed. Results and Discussion: In our study, XP was more common in females compared to males. In our study of patients with XP, average fasting blood sugar was 108 gm% and average post prandial blood sugar was 152gm%. Average serum triglyceride levels in patients with XP was 171.4 mg/dl, compared to 108.4 mg/dl in control group with significant p value i.e. 0.001, suggesting strong correlation between XP and serum triglyceride levels. Conclusion: Patients with XP usually visit doctor with cosmetic concern. In most of the cases of XP, serum cholesterol, triglyceride and VLDL levels are deranged. Patients with XP should be evaluated for above parameters and systemic management done along with treatment of XP.

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Section: Resultssupporting

confidence: 93%

“…5,8 In study by Jain et al, most of the cases were aged between 31-40 years. 7 Chhetri et al reported a different peak age group of 40-50 years and found 41.84 % of the XP cases in this age group. 12 Previous studies have reported correlation between diabetes and hypertension to XP.…”

Section: Fig 1: 81% Females and 19% Malesmentioning

confidence: 95%

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

2020

IJN

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“…This was in concordance with a study conducted in a tertiary hospital in Delhi by Jain et al 11 No statistically significant association of IGH with diabetes was present in our study. No statistically significant association of vitiligo with diabetes was present in our study.…”

Section: Discussionsupporting

confidence: 94%

A Clinical Study of Geriatric Dermatoses

Preeja¹,

Ashok²,

Samson³

2017

jemds

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BACKGROUND Geriatric population is increasing worldwide. Hence, a proper understanding of geriatric skin disorders is important for a dermatologist. Though there are a large number of studies on the pattern of geriatric dermatoses, there is a scarcity of such studies in Kerala in the available literature. Aims-To study the pattern of dermatoses in geriatric population and to analyse the association of common geriatric dermatoses with systemic illnesses. MATERIALS AND METHODSThis was a descriptive study in which patients aged sixty years and above who attended the Geriatric Department of a tertiary care centre in Kerala was studied. Detailed dermatological examination was done and relevant laboratory investigations were done. Association of geriatric dermatoses with systemic illnesses was analysed. RESULTSNon-infective dermatoses outnumbered infective dermatoses. Xerosis was the commonest dermatosis. Glogau wrinkling scale was Grade III in the majority of patients. A statistically significant association of xanthelasma palpebrarum with dyslipidaemia and cherry angioma with diabetes was noted in the study. CONCLUSIONDermatological findings in geriatric population was universal in this study. This would necessitate the need for conducting dermatological clinics for these patients.

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“…The commonly noted associations included AN, acne, androgenetic alopecia, hirsutism, and xanthelasma palpebrarum. All of them are associated with metabolic syndrome components [4,28]. Similarly, we noted systemic conditions such as hT, weight gain or obesity, DM and menstrual irregularity and/or polycystic Przegląd Dermatologiczny 2017/1 ovarian syndrome (PCOS), which have been linked to MS [4].…”

Section: Resultsmentioning

confidence: 53%

A clinicoepidemiological study of skin tags and their association with metabolic syndrome

Srivastava¹,

Khare²,

Gupta³

et al. 2017

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Introduction. Skin tags are known to be associated with several systemic diseases such as diabetes mellitus, obesity, dyslipidemia and cardiovascular diseases. Only a few Indian studies have investigated patients with skin tags for underlying metabolic complications. Objective. To assess the clinico-epidemiological profile of patients with skin tags and evaluate them for underlying metabolic abnormalities. Material and methods. All the patients reporting skin tag(s) at the dermatology outpatient department from October 2013 to September 2014 were included in the study. A detailed general, cutaneous and systemic examination was carried out. The data were analyzed using the c 2 test. A p-value < 0.05 was considered significant. Results. Out of 165 enrolled patients, 112 (67.88%) completed the study protocol. Females outnumbered males, the M : F ratio being 1 : 1.11. Most patients (32; 28.57%) were in the age group of 31-40 years. The majority of the patients (77; 68.75%) reported after 1 year of noticing the lesions. The most commonly affected site was the neck (99; 88.39%) followed by the axilla (53; 47.32%). Acanthosis nigricans was the most common skin disease associated with skin tags (37; 33.03%). The diagnostic criteria for metabolic syndrome were fulfilled by 47 (41.96%) patients. The majority of the patients (70; 62.5%) were either overweight or obese. Abnormal glucose tolerance and hypertension were found in 41 (36.6%) and 37 (33.03%) of the patients respectively. Above optimal LDL cholesterol was the most common lipid abnormality, detected in 64 (56.25%) of the cases. Patients with 11 or more skin tags lesions and those with involvement of the thigh, axilla or neck were more likely to have metabolic syndrome. Conclusions. Patients with skin tags should be screened for concomitant diseases such as diabetes, hypertension, dyslipidemia and cardiovascular disease. Early detection of these complications followed by appropriate lifestyle changes and/or drug therapy would be beneficial in terms of reducing the considerable morbidity and mortality.

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Xanthelasma Palpebrarum-clinical and biochemical profile in a tertiary care hospital of Delhi

Cited by 42 publications

References 14 publications

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

A Clinical Study of Geriatric Dermatoses

A clinicoepidemiological study of skin tags and their association with metabolic syndrome

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