Xanthelasma palpebrarum: a new adverse reaction to intradermal fillers?

D'Acunto, Carmine; Pazzaglia, Massimiliano; Raone, Beatrice; Misciali, C.; Badiali, Lucilla; Neri, Iria; Patrizi, Annalisa

doi:10.1111/j.1365-2133.2012.11152.x

Cited by 10 publications

(11 citation statements)

References 11 publications

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“…13,24,25 There is no standard treatment for xanthelasma-like reactions, and many cases are not treated. 18,26 Oral steroids, hyaluronidase, and 5-FU did not improve the appearance of these yellow plaques. 26 Trichloroacetic acid (TCA) peels and ablative and fractional CO2 lasers were also employed, which led to subtotal improvements.…”

Section: Triggering or Predisposing Factorsmentioning

confidence: 89%

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Trinh

McGuigan

Gupta³

2021

Facial Plast Surg

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Tear trough deformity is a popular target for the treatment with filler injections. The side effects are generally mild and transient. However, delayed complications may occur. We aim to perform a thorough systematic review of the published literature related to delayed complications after tear trough filler injections. A search of published literature was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in June 2021 and included PubMed, ScienceDirect, and Embase databases. The Medical Subject Headings (MeSH) terms used included the following terms: delayed complications, nodules, granulomas, swelling, discoloration, dermal filler, hyaluronic acid (HA), polyacrylamide, calcium hydroxyapatite (CaHA), poly-L-lactic acid (PLLA), eyelid, periorbital, periocular, and tear trough. Twenty-eight articles consisting of 52 individual cases were included in the final analysis. 98% (51/52) of patients were female and had an average age of 48.3 years. HA was the most reported product (71.2%, 37/52), followed by PLLA (4/52, 7.7%), and CaHA (4/52, 7.7%). The most common delayed complication with any dermal filler was swelling (42.3%, 22/52) followed by lumps or nodules (25.0%, 13/52). Xanthelasma-like reaction (17.3%, 9/52), migration (7.7%, 4/52), discoloration (3%, 3/52) also occurred. The average time of onset of any complication was 16.8 months with xanthelasma-like reaction appearing soonest (mean: 10 months) and discoloration appearing latest (mean: 52 months). Most swelling cases were caused by HA. Semi-permanent fillers such as PMMA and synthetic fillers such as PLLA were more likely to be associated with lumps and nodules than other complications. It is important that clinicians who perform tear trough augmentation with dermal fillers have a thorough understanding of the risks of the procedure to diagnose and manage them promptly as well as provide patients with accurate information regarding the potential adverse effects.

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Section: Triggering or Predisposing Factorsmentioning

confidence: 89%

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Trinh

McGuigan

Gupta³

2021

Facial Plast Surg

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“…Des injections d'acide hyaluronique dans les paupières inférieures provoquent des xanthélasmas. D'Acunto et al [93] présentent 2 cas bien documentés, sans hyperlipidémie, avec en microscopie électronique l'acide hyaluronique et des inclusions lipidiques dans les histiocytes.…”

Section: Dangers De La Dermatologie « Esthéticienne »unclassified

Quoi de neuf en dermatologie clinique ?

Janier

2013

Annales de Dermatologie et de Vénéréologie

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2013 has been the year of large genetic studies of the GWAS type (Genome wide association studies) in common diseases such as psoriasis and atopic dermatitis, aimed at localization of candidate genes. It was also the year of population-based studies from huge public or private registers. Thus, epidemiologic correlations have been put forward: psoriasis and vascular risk, psoriasis and rhinosinusitis, rosacea and migraine, acne and food habits, eczema and basal-cell carcinoma, vitiligo and lower risk of skin cancer, cutaneous Ro/SS-A pos lupus and cancer, chronic eczema and calcium-channel inhlbitors, pemphigoid and loop diuretics. Risk of IBD induced by isotretinoin has not been confirmed but risk of skin cancer under azathioprine is real. New drug reactions have appeared (pigmentation due to interferon, hypodermitis and sarcoidosis to anti-BRAF, vandetanib) and old ones are revisited (patch-testing of Severe Cutaneous adverse cutaneous reactions, pigmentation due to anti-malarial drugs, neutrophilic dermatosis due to azathioprine). Diane35(®) has been transiently withdrawn in January 2013 but tetrazepam has been withdrawn definitively in July 2013. Original aspects of cutaneous infections will be discussed along with new data on STDs (meningococcemia in MSMs, HPV, Herpes, congenital syphilis). Finally, some important papers about dermoscopy, confocal microscopy and aesthetic dermatology will be presented.

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“…Since intradermal filler usage has expanded, more complications have been seen. Xanthelasma palpebrarum (XP) has been proposed as a new adverse reaction to intradermal fillers 1 . Here, we report a case of a 38‐year‐old woman who underwent hyaluronic acid (HA) filling in the periorbital area and presented twelve months after with two symmetrically lesions on the lower eyelids that appeared to be xanthelasma.…”

Section: Introductionmentioning

confidence: 97%

Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature

Pires¹,

Wender

Santos³

et al. 2021

J of Cosmetic Dermatology

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Background Hyaluronic acid filler treatments are a very popular nonsurgical procedure worldwide, most wanted to create a more attractive profile and correct facial aging. Since its usage has expanded, more complications have been seen. Aims To report a probably new adverse effect related to injectable fillers. Patient A 38‐year‐old white woman who underwent hyaluronic acid filling in the periorbital area and presented twelve months after with two symmetrically yellowish plaque lesions on the lower eyelids, with no edema or nodules. Results The lesion appeared to be xanthelasma, in a patient with no history of hyperlipidemia. Histological analysis showed unspecific findings with rare histiocytes present in the papillary dermis. The patient was treated with hyaluronidase infiltration in both lower eyelid areas as an attempt to minimize the appearance of the lesions, with a satisfactory response. Conclusions As hyaluronic acid fillings are becoming more popular, all physicians have to be aware of its complications. The xanthelasma‐like reaction is probably a new adverse effect related to injectable fillers and it is important to be alert to this possibility.

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Xanthelasma palpebrarum: a new adverse reaction to intradermal fillers?

Cited by 10 publications

References 11 publications

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Quoi de neuf en dermatologie clinique ?

Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature

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