Xanthan gum in drug release

Abstract

Controlled release is of vital relevance for many drugs; thus, there is a keen interest in materials that can improve the release profiles of formulations administered via buccal, transdermal, ophthalmic, vaginal, and nasal. The desirable effects of those materials include the improvement of stability, adhesiveness, solubility, and retention time. Hence, different synthetic and natural polymers are utilized to achieve these objectives. In this respect, xanthan gum is an anionic polysaccharide that can be obtained from Xanthomonas bacteria. It is a natural polymer broadly employed in numerous food products, lotions, shampoos, and dermatological articles. Furthermore, due to its physicochemical features, xanthan gum is growingly utilized for the development and improvement of drug delivery systems. In this regard, encouraging findings have been revealed by recent formulations for pharmaceutical applications, including antiviral carriers, antibacterial transporters, transdermal patches, vaginal formulations, and anticancer medications. In this article, we perform a concise description of the chemical properties of xanthan gum and its role as a modifier of drug release. Furthermore, we present an outlook of the state of the art of research focused on the utilization of xanthan gum in varied pharmaceutical formulations, which include tablets, films, hydrogels, and nanoformulations. Finally, we discuss some perspectives about the use of xanthan gum in these formulations.

Marine Polysaccharides for Wound Dressings Application: An Overview

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Water‐soluble polymers in agriculture: xanthan gum as eco‐friendly alternative to synthetics

“…In cosmetics, xanthan gum serves as stabilizer and thickener, for example in toothpastes, creams, lotions, gels and shampoos. It is also relevant for pharmaceutical applications, modifying drug release from delivery systems such as tablets, films, hydrogels and nanoformulations (Cortes et al ., 2020) and potential base material in tissue engineering (Petri, 2015; Kumar et al ., 2018). Typical industrial applications of xanthan gum are in cleaners, paints, ceramic glazes, inks, oil drilling fluids or agricultural flowables (Katzbauer, 1998).…”

Radiation-induced graft polymerization of elastin onto polyvinylpyrrolidone as a possible wound dressing

“…In this regard, the use of dressings as a treatment for wound healing signifies an attractive option because they promote an ideal micro-environment for recovery, preserve the moisture in the wound, provide adequate gas exchange, stimulate the synthesis of growth factors, and protect the wound from pathogens (1,2). In recent years, the use of wound dressings based on biopolymers has generated massive interest because they offer certain advantages over other materials (3)(4)(5), such as biocompatibility, high biodegradability, and the ability to stimulate the tissue regeneration (6). Moreover, these biopolymers can be combined with other synthetic polymers to form reinforced dressings such as hydrogels.…”