Untitled

Abstract

Our century is characterized by the introduction of innovative technologies that are used in all spheres of life, including in pedagogy, which helps to familiarize students with modern medical and pharmaceutical technologies. These drugs are obtained by using biological objects by means of special technological processes of cell engineering, hybrid technologies, engineering enzymology, engineering immunology, and others. Biotechnological preparations include certain antibiotics, hormonal and vitamin preparations, blood preparations, cytokines, immunomodulators, enzymes, lipids, polysaccharides, monoclonal antibodies, and others. Biotechnological preparations differ from chemical synthesis drugs not only in their production technology, but also in their significant molecular weight, complexity of the spatial structure of the protein, a certain ratio of isoforms, instability of molecules, and other properties. At the same time, they have a significant cost due to the complexity of the technological process: it is impossible to create analogues of biotechnological drugs by chemical synthesis. If desired to reproduce biotechnological products, biosimilars are obtained which must be subjected to complete preclinical (in vitro and in vivo) studies, taking into account the definition of pharmacokinetics and clinical trials. In Ukraine the exchange of biosimilars is regulated by the pharmacovigilance system. To improve the quality of teaching the pharmacology to students of medical and pharmaceutical faculties, it is necessary to modernize educational technologies. For this purpose, biotechnological preparations are included in the pharmacology program for students of medical and pharmaceutical faculties.