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Fish,

doi:10.1016/1076-0512(95)00575-7

Cited by 30 publications

(8 citation statements)

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“…Because they are dermal-based tumors, they may appear fixed to the epidermis and ulceration may be present. [20] The lower extremities and head and neck locations are the most common sites of involvement as identified in our series and in the literature. [3, 14, 21] Pre-operative staging with cross-sectional imaging (CT thorax and/or PET imaging) appeared to add minimal clinical impact in our experience as more than half of the patients in this series underwent imaging, all of which were negative.…”

Section: Discussionmentioning

confidence: 73%

“…[14] Others have suggested using a 3-5 cm margin of excision because of the potential risk of local recurrence and distant metastasis. [20] Narrow margin excision[13] and even Mohs micrographic surgery have also been used. [10, 11, 28] While several small case series using Mohs resection have been described, recurrences have been reported with long-term follow up.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

et al. 2013

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Introduction Cutaneous leiomyosarcoma (LMS) is a rare dermal-based tumor for which treatment algorithms have been poorly defined. We report our single institution experience treating cutaneous LMS using a median of a 1 cm margin for resection. Methods An IRB approved review of patients with cutaneous LMS from 2005-2010 was performed with outcomes reported. Results 33 patients with cutaneous LMS were treated, 76% were male, 97% were Caucasian with a median age of 63.5 years. 67% of tumors were located on the extremities. Pre-operative staging was negative for distant metastasis in all patients. 88% of tumors were low grade with a median tumor size of 1.3 cm. 100% of tumors tested for smooth muscle actin were positive. A majority (94%) of patients underwent primary surgical resection with a median margin of 1 cm. Final resection margin was negative in 32/33 (97%). Adjuvant radiotherapy was used in 15%. There were no recurrences or metastastic spread and 100% were alive at last follow up, median of 15.5 months. Conclusions Cutaneous LMS is primarily a low-grade malignancy affecting elderly male Caucasians. Good oncologic control and an excellent outcome are possible with a 1 cm resection margin in the vast majority of cases.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

et al. 2013

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“…In general, dermal tumors appear adhered to the epidermis with frequent ulceration of skin with or without crusts, while subcutaneous tumors are mobile. [15] Our patient was a 77-year-old male who presented with a sacral mass of 7 cm × 5 cm × 5 cm, with brownish discoloration and ulceration of the skin. As he was a farmer by occupation, there is possibility of trauma, which might have gone unnoticed in his case.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous leiomysarcoma

et al. 2011

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Primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm, accounting for about 2–3% of all superficial soft tissue sarcomas. It arises between the ages of 50 and 70 years, and shows a greater predilection for the lower extremities. Clinically, it presents with solitary, well-circumscribed nodule and, microscopically, consists of fascicles of spindle-shaped cells with “cigar–shaped” nuclei. Local recurrence is known in this tumor. We document a case of primary cutaneous leiomyosarcoma in a 77-year-old man and discuss the histological features and immunohistochemical profile of this uncommon neoplasm.

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“…These tumours are locally aggressive and highly recurrent, but metastases or tumour-related deaths are extremely rare (Enzinger and Weiss, 1995;Fish, 1996;Mentzel et al, 1998). DP presents speci®c cytogenetic features such as reciprocal translocations t(17;22)(q22;q13.1) or more often, supernumerary ring chromosomes derived from t(17;22) (Pedeutour et al, 1995(Pedeutour et al, , 1996.…”

Section: Introductionmentioning

confidence: 99%

Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma Protuberans (DP)

et al. 2001

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Dermato®brosarcoma protuberans (DP), an in®ltrative skin tumour of intermediate malignancy, presents speci®c cytogenetic features such as reciprocal translocations t(17;22)(q22;q13.1) or supernumerary ring chromosomes derived from t(17;22). We have previously shown that both rings and translocated chromosomes derived from t(17;22) presented the same molecular rearrangement with fusion of the COL1A1 gene on chromosome 17 to the PDGFB gene on chromosome 22. To study the structure and function of the COL1A1 ± PDGFB chimeric protein, we used a tumour-derived chimeric COL1A1 ± PDGFB cDNA to perform stable and transient transfections in the Chinese hamster lung ®broblastic cell line PS200 and the human epithelial cell line HEK293. We demonstrated that the stably transfected clones that expressed the COL1A1 ± PDGFB chimeric protein became growth factors independent and tumorigenic in nude mice. In addition, COL1A1 ± PDGFB transfected cell supernatants signi®cantly stimulated ®broblastic cell growth, through the activation of the PDGFB receptor pathway. By using anti-PDGFB and speci®c anti-COL1A1 ± PDGFB antibodies, we showed that, similar to PDGFB, the COL1A1 ± PDGFB chimeric proteins are processed in transfected cells into mature PDGFB dimers. These results strongly suggest that the COL1A1 ± PDGFB chimeric gene expression associated with DP, induces tumours formation through production of mature PDGFB, in an autocrine or paracrine way. Strikingly, mutagenesis experiments indicated that uncleaved COL1A1 ± PDGFB forms are mitogenic and therefore could contribute, as well as mature PDGFB, to the establishment of a transformed phenotype. Oncogene (2001) 20, 2965 ± 2975.

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Cited by 30 publications

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Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

Cutaneous Leiomyosarcoma: Treatment and Outcomes with a Standardized Margin of Resection

Primary cutaneous leiomysarcoma

Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma Protuberans (DP)

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