X-Trisomy in cattle with signs of familial disposition for meiotic disturbances

Abstract

For the first time a case of X-trisomy (XXX-gonosome aberration) in a Fleckvieh-heifer is reported. Cytogenetic examination of leukocytes and tissue cultures from the skin of this animal gave in 100% of the examined cells the karyotype 2N = 61, XXX. Except for a pronounced kyphosis of the lumbar column, there were no clinical symptoms. Sex organs and sexual function showed nothing peculiar. The teratogram from the father of the XXX-heifer showed genetical connections in the etiology of kyphosis. It seems also that in the family line an inherent genetical disposition to meiotic disturbances, in the sense of non-disjunction, exist because recently a case of an XXY-gonosome abnormality with bilateral testicle hypoplasia (bovine hypogonadism) was registered in the second generation of the father’s breed.

Analysis of Meiotic Segregation Pattern and Interchromosomal Effects in a Bull Heterozygous for a 3/16 Robertsonian Translocation

“…These chromosomes were chosen because they had been involved in constitutional aneuploidies previously diagnosed in cattle [Rieck et al, 1969[Rieck et al, , 1970[Rieck et al, , 1982Dain and Bridge, 1978;Dunn et al, 1980;Buoen et al, 1981;Miyake et al, 1981Miyake et al, , 1984Herzog et al, 1982;Mayr et al, 1985;Moreno-Millán et al, 1987;Murakami et al, 1989;Kovács et al, 1990;Herzog and Höhn, 1991;Kulikova et al, 1991;Agerholm and Christensen, 1993;Christensen and Juul, 1999;Gallagher et al, 1999;Molteni et al, 1999;Ducos et al, 2000;Iannuzzi et al, 2001;Słota et al, 2003]. Painting probes were used for chromosomes BTAX and BTAY.…”

Disorders of Sexual Development and Abnormal Early Development in Domestic Food-Producing Mammals: The Role of Chromosome Abnormalities, Environment and Stress Factors

“…In domestic animals, XXY-trisomy leads to a syndrome known as Klinefelter syndrome in humans. It is very rare in cattle [Rieck et al, 1970;Herzog et al, 1977;Ducos et al, 2008] and river buffalo [Patel et al, 2006]. Carriers are characterized by bi-lateral testicular hypoplasia [Dunn et al, 1979].…”