X-STR decaplex study on the population of Czech Republic

Zidkova, Anastassiya; Coufalova, P.; Capek, P

doi:10.1007/s00414-013-0860-5

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Argus X‐12 was compared with autosomal STR kit PowerPlex ESI‐17 (Promega, USA) and Decaplex X‐STR containing 8 unlinked X‐STRs and one linked pair (DXS6809‐DXS6789). For PowerPlex ESI‐17 and Decaplex X‐STR allele frequencies from Hill et al and Zidkova et al , respectively, were used. Kinship was determined in the case of six female–female duos by computing likelihood ratio (LR).…”

Section: Methodsmentioning

confidence: 99%

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Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis

et al. 2014

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DNA samples of 523 unrelated anonymized individuals (307 males and 216 females) born and living in the Czech Republic were genotyped using Investigator® Argus X-12 system in the following loci localized in four linkage groups: DXS10148, DXS10135, DXS8378, DXS7132, DXS10079, DXS10074, DXS10103, HPRTB, DXS10101, DXS10146, DXS10134, DXS742. Haplotype frequencies were calculated for each LG (Linkage Group). The frequency of most common haplotype was 0.016, 0.036, 0.042, and 0.023 for LG1, LG2, LG3, and LG4, respectively. The combined power of discrimination was more than 0.999999999 both for female and male samples. The mean exclusion chance was 0.99999999 (trios) and 0.999999 (duos). Informativity and suitability of Investigator® Argus X-12 for kinship determination was assessed by computing in several female-female duos using LR (Likelihood Ratio) determination for autosomal STR (PowerPlex ESI-17), linked (Investigator® Argus X-12 system), and unlinked (X-STR Decaplex) X-STR kits. Investigator® Argus X-12 proved to be very useful for sibship determination, since its LR values were relatively similar to LR for autosomal STR kit. This work presents the first population data for Investigator® Argus X-12 system in the Czech Republic.

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Section: Methodsmentioning

confidence: 99%

“…Nowadays more than 94% of people living in the Czech Republic declare themselves as Czechs, thereby creating an overwhelming majority . Several population studies involving autosomal STRs , Y‐STRs , insertion‐deletion polymorphisms , and unlinked X‐STRs were performed on Czech population.…”

Section: Introductionmentioning

confidence: 99%

Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis

et al. 2014

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“…[132]), Czech Republic (e.g. [133]), Denmark [134], France [135], Finland (e.g. [136]), Greece [137], Hungary [138], Ireland [135], Latvia [139], Lithuania [122], Poland (e.g.…”

Section: Worldwide Populationsmentioning

confidence: 99%

Applications of X-Chromosome Short Tandem Repeats for Human Identification: A Review

Mahat

Alwi²,

Salleh³

et al. 2023

J.Trop.Life.Science

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The forensic DNA profiling technique has tremendously contributed to forensic human identification, an important aspect in forensic investigations. In instances whereby comparison samples are unavailable, utilization of short tandem repeats of X chromosome (X-STRs) may prove useful to resolve complex kinship investigations involving missing persons and mass disasters. Despite such evidential values, the use of X-STRs during investigations remains scarce in many Southeast Asian countries including Malaysia, requiring concerted efforts for establishing forensic statistical support for its diverse populations (especially the admixture populations), standardizing core loci and procedure, improving the knowledge among practitioners as well as developing suitable standard operating procedure for incorporating X-STRs analysis in the overall DNA profiling framework. Hence, this review paper aims to highlight the developments, applications and population data of X-STRs, as well as its challenges and future insights for forensic casework.

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“…Como en el resto del genoma humano, los marcadores STRs son abundantes a lo largo del cromosoma X con una densidad comparable a los STRs autosómicos. Hasta la presente fecha se han identificados 55 STRs en el cromosoma X y se han caracterizados en más de 50 poblaciones (http://www.chrx-str.org/) de estos 55 X-STRs, 28 han sido utilizados con fines forenses [7][8][9][10][11] . El objetivo de este trabajo fue caracterizar secuencias de tipo STR del cromosoma X (DXS8378, DXS9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7133, GATA172D05, GATA31E08 y DXS7423) en una muestra de la población del Estado Zulia, Venezuela.…”

Section: Trabajos Originalesunclassified

Autopsia en muertes por Covid-19: análisis y recomendaciones a través de una revisión

Rubio

Suárez

Santos

et al. 2020

Rev. cienc. forenses Honduras

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Justificación: La autopsia es el procedimiento fundamental para determinar las causas de muerte, provee información crítica para ser correlacionada con la clínica, epidemiología y fisiopatolología de enfermedades con altas tasas de mortandad. Los hallazgos patológicos de las autopsias deben confirmar el diagnóstico clínico y determinar los efectos del tratamiento para fundamentar terapias eficaces. La infección por SARS-Cov-2 al tratarse de una enfermedad nueva con implicaciones sin precedentes para la humanidad, ha generado múltiples trabajos científicos para entenderla desde diferentes puntos de vista. Objetivos: Los propósitos de la revisión fueron: analizar la literatura disponible sobre autopsias de pacientes con infección por SARS-CoV-2, identificar los principales hallazgos patológicos reportados y determinar las condiciones técnicas en que se hicieron esos procedimientos. Metodología: Se utilizaron los buscadores bibliográficos (PubMed, Google Scholar, Dialnet, Scielo), usando las palabras Autopsia, Postmortem y COVID-19, para localizar la literatura sobre las autopsias de pacientes con infección por SARS-CoV-2. Resultados: Se obtuvieron 16 artículos científicos que cumplieron los criterios de búsqueda, en siete se reportaron 83 autopsias de 54 varones y 16 mujeres, con edad promedio de 60,91 años. El análisis anatomopatológico se enfocó especialmente en los pulmones, que macroscópicamente estaban pesados por edema y congestión. Microscópicamente había daño alveolar difuso (membranas hialinas o de organización con angiogénesis y microtrombos) e infiltración linfocitaria intersticial. En 18 autopsias también analizaron otros órganos como corazón, hígado, riñón y bazo. Conclusión: A pesar del incremento de trabajos de investigación sobre la enfermedad, Covid-19 los estudios basados en autopsia son muy escasos y limitados. Un aumento en el número de autopsias realizadas a los fallecidos por COVID-19 proveería mayor conocimiento de las características de la enfermedad, la causa de la muerte, la extensión de la misma y efectos del tratamiento.

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X-STR decaplex study on the population of Czech Republic

Cited by 6 publications

References 9 publications

Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis

Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis

Applications of X-Chromosome Short Tandem Repeats for Human Identification: A Review

Autopsia en muertes por Covid-19: análisis y recomendaciones a través de una revisión

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