Single crystalline C 70 nanotubes having a face-centered-cubic (fcc) structure with diameters in the nanometer scale were synthesized by a facile solution method. In-situ high pressure Raman spectroscopy and X-ray diffraction have been employed to study the structural stability and phase transitions of the pristine sample. We show that the molecular orientation related phase transition from the fcc structure to a rhombohedral structure occurs at about 1.5 GPa, which is ~1 GPa higher than in bulk C 70 . Also, the C 70 molecules themselves are more stable in the nanotubes than in bulk crystals, manifested by a partial amorphization at ~20 GPa. The crystal structure of C 70 nanotubes could partially return to the initial structure after a pressure cycle above 30.8 GPa, and the C 70 molecules were intact up to 43 GPa. The bulk modulus of C 70 nanotubes is measured to be ~50 GPa, which is twice larger than that of bulk C 70.2