X-ray structural investigation of sesquiterpene esters from plants of the genusFerula

Sesquiterpene Coumarins and Related Derivatives from Ferula pallida

“…Six new compoundsstwo sesquiterpene coumarins, pallidones A and B (1, 2), and four related derivatives, pallidones C-F (3)(4)(5)(6), as well as two known sesquiterpene coumarins, feselol (7) and conferol (8), have been isolated from the EtOAc extracts of the roots of Ferula pallida. All structures of these compounds were determined on the basis of spectral evidence, especially 2D NMR ( 1 H-1 H COSY, HSQC, HMBC, and NOESY) and HRMS.…”

“…The chemical constituents of the genus Ferula (Umbelliferae) have been studied by many groups in the past. Compounds commonly found in this genus are sesquiterpenes − (especially daucanes, humulanes, himachalanes, and guaianes) and sesquiterpene coumarins . A recent chemical study of F. sinaica also showed the main components to be sesquiterpene coumarins and sesquiterpenes .…”

Sesquiterpenes from Ferula penninervis

“…The chemical constituents of the genus Ferula (Apiaceae) have been studied by many groups. Compounds commonly found in this genus are sesquiterpenes (especially daucanes, humulanes, himachalanes, and guaianes), − sesquiterpene coumarins, , and dimeric coumarins . Previous chemical studies on F. penninervis Regel and Schmalh also showed that the main components are sesquiterpenes. , We report herein the isolation and structure elucidation of 17 new compounds [15 guaiane-type sesquiterpenes, ferupennins A−O ( 1 − 15 ), 1α-hydroxy-2-oxo-5α,7β-11βH-eudesm-3-en-6α,12-olide ( 16 ), and penninervin ( 17 )] along with nine known sesquiterpenes [decipienin F, talassin B, laferin, oferin, olgin, carmenin, 4β,10α-dihydroxyaromadendrane, isolasolide, and lasolide 17 ].…”

Sesquiterpene Chromones from Ferula fukanensis and Their Nitric Oxide Production Inhibitory Effects

“…In previous papers, − we reported the isolation of sesquiterpene coumarin derivatives and sesquiterpene phenylpropanoids from F. fukanensis . Compounds commonly found in this genus are sesquiterpenes − (especially daucanes, humulanes, and guaianes), sesquiterpene coumarins, and sesquiterpene chromones. − In our continuing investigations of in vitro anti-inflammatory effects of medicinal herbal extracts, the 80% aqueous methanol extract of the roots of F. fukanensis was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage-like cell line …”