X-ray refraction effects: application to the imaging of biological tissues

Lewis, Robert A.; Hall, Chris; Hufton, Alan; Evans, S.H.; Menk, R.H.; Arfelli, Fulvia; Rigon, Luigi; Tromba, Giuliana; Dance, David R.; Ellis, Ian; Evans, Andrew; Jacobs, Elizabeth R.; Pinder, Sarah; Rogers, Keith

doi:10.1259/bjr/32889803

Cited by 105 publications

(73 citation statements)

References 10 publications

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“…1 Hence, XPCi methods can provide superior contrast for many soft tissue specimens. 1 Different XPCi methods exist, both as planar and computed tomography (CT) modalities, [2][3][4][5][6][7][8] and all of them are compatible with microfocal and/or synchrotron radiation x-ray sources. Several techniques have been demonstrated to be also compatible with standard (nonmicrofocal) x-ray sources.…”

Section: Introductionmentioning

confidence: 99%

Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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Purpose:The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. Methods: Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-tonoise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed. Results:The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity. Conclusions:The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.

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Section: Introductionmentioning

confidence: 99%

Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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“…Recent phase contrast imaging is improving but remains significantly difficult to quantify. Lewis et al 32) applied the x-ray diffraction enhanced imaging in dissected mouse lung, heart, liver and legs.…”

Section: Discussionmentioning

confidence: 99%

“…20 (1): [31][32][33][34][35][36], 2011 resolved. Moreover, the recovered electron density map provides contrast high enough to estimate nanoscale bone density variations.…”

mentioning

confidence: 99%

A Preliminary Study on Low-dose X-ray Imaging Using Parametric X-ray

Tanaka

Hayakawa

Takahashi

et al. 2011

J. Hard Tissue Biology.

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Abstract:Parametric X-ray (PXR) is a new type of radiography with variable monochrome wavelength and high coherent characteristics. The Laboratory for Electron Beam Research and Application (LEBRA) at Quantum Science Institute, Nihon University generated LEBRA-PXR, a system that irradiates Si crystal with electron accelerated by linear accelerator (LINAC). LEBRA-PXR is uniquely developed for world-wide application experiment. X-ray images of tooth samples were taken with flat panel detector using LEBRA-PXR. As a result, images were captured as short as 1 sec. LEBRA-PXR uses LINAC with micro-macro pulse electron beam structure. Imaging time of 1 sec is equivalent to about 0.025 msec when x-ray is converted to actual radiation exposure. The effective dose point estimates of x-rays were about 1 µ Sv/5 sec. Results show that LEBRA-PXR can be used to generate low dose x-ray imaging advocating the possibility of its application in biological studies and medical treatment.

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“…Recent phase contrast imaging is improving but remains significantly difficult to quantify. Lewis et al 9) applied the x-ray diffraction enhanced imaging in dissected mouse lung, heart, liver and legs. The results showed markedly enhanced boundaries of different tissues and three-dimensional appearance.…”

Section: Hiroyuki Okada Et Al: Basic Study Of Pxr For Clinical Diagnmentioning

confidence: 99%

Basic Study of Parametric X-ray Radiation for Clinical Diagnosis using 125MeV Linear Particle Accelerator

Okada

Kaneda

Koike

et al. 2015

J. Hard Tissue Biology.

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Abstract:We demonstrated some different contrasts of cat mandibular squamous cell carcinoma using parametric X-ray radiation at the Laboratory for Electron Beam Research and Application at Nihon University (LEBRA-PXR). A conventional X-ray image revealed a bone tumorous lesion in the mandible. LEBRA-PXR images (20, 25 and 30KeVs) showed some contrasts related to the wavelengths. LEBRA-PXR displayed contrasts which differed from those of conventional X-ray images, suggesting LEBRA-PXR may be useful for diagnostic imaging as a new X-ray source.

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X-ray refraction effects: application to the imaging of biological tissues

Cited by 105 publications

References 10 publications

Low-dose phase contrast tomography with conventional x-ray sources

Low-dose phase contrast tomography with conventional x-ray sources

A Preliminary Study on Low-dose X-ray Imaging Using Parametric X-ray

Basic Study of Parametric X-ray Radiation for Clinical Diagnosis using 125MeV Linear Particle Accelerator

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