X-ray refraction-contrast computed tomography images using dark-field imaging optics

Sunaguchi, Naoki; Yuasa, Tetsuya; Huo, Qingkai; Ichihara, Shu; Ando, Masami

doi:10.1063/1.3497717

Cited by 39 publications

(14 citation statements)

References 15 publications

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“…Grating-based imaging involves the use of grating optics between the source and sample and can be performed using a laboratory X-ray source or a synchrotron source [31,32]. Angle-analyzer-based methods employ a single crystal plate as an angular analyzer to obtain the refraction angle [5,8,33,34]. All of these techniques have been extended to tomographic imaging.…”

Section: Setups For Phase Extractionmentioning

confidence: 99%

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

et al. 2020

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The basic idea of X-ray dark-field imaging (XDFI), first presented in 2000, was based on the concepts used in an X-ray interferometer. In this article, we review 20 years of developments in our theoretical understanding, scientific instrumentation, and experimental demonstration of XDFI and its applications to medical imaging. We first describe the concepts underlying XDFI that are responsible for imparting phase contrast information in projection X-ray images. We then review the algorithms that can convert these projection phase images into three-dimensional tomographic slices. Various implementations of computed tomography reconstructions algorithms for XDFI data are discussed. The next four sections describe and illustrate potential applications of XDFI in pathology, musculoskeletal imaging, oncologic imaging, and neuroimaging. The sample applications that are presented illustrate potential use scenarios for XDFI in histopathology and other clinical applications. Finally, the last section presents future perspectives and potential technical developments that can make XDFI an even more powerful tool.

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Section: Setups For Phase Extractionmentioning

confidence: 99%

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

et al. 2020

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“…Tomographic images of organic tissue using synchrotron radiation have been reported to be superior to conventional imaging modalities [ 6 , 7 ]. This micrometric radiation single beam directed by a monochromator installed in the beamline to receive a white radiation emitted from electrons accelerating at almost the speed of light has been a useful tool, being able to acquire higher-resolution images from small samples of sub-millimeters, even comparable with pathologic features [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…A refraction-based tomographic technique called X-ray dark-field imaging (XDFI) has been evolved to be adapted for deriving internal information from soft tissue, including animal and human specimens, for fifteen years [ 9 ]. For biomedical use, a refraction-based tomographic imaging system using synchrotron radiation can show higher-resolution capability with a lower radiation dose compared with conventional tomographic techniques based on absorption contrast theory [ 7 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations

Sunaguchi

Lee

et al. 2021

Diagnostics

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The aim of this study was to evaluate the clinical implication of synchrotron radiation imaging techniques for human lung adenocarcinoma in comparison with pathologic examination. A refraction-based tomographic imaging technique called the X-ray dark-field imaging (XDFI) method was used to obtain computed tomographic images of human lung adenocarcinoma at the beam line at Photon Factory BL 14B at the High Energy Accelerator Research Organization (KEK) in Tsukuba, Japan. Images of normal lung tissue were also obtained using the same methods and reconstructed as 3D images. Both reconstructed images were compared with pathologic examinations from histologic slides which were made with identical samples. Pulmonary alveolar structure including terminal bronchioles, alveolar sacs, and vasculatures could be identified in synchrotron radiation images of normal lung. Hyperplasia of interstitial tissue and dysplasia of alveolar structures were noticed in images of lung adenocarcinoma. Both synchrotron radiation images were considerably correlated with images from histologic slides. Lepidic patterns of cancer tissue were distinguished from the invasive area in synchrotron radiation images of lung adenocarcinoma. Refraction-contrast tomographic techniques using synchrotron radiation could provide high-resolution images of lung adenocarcinoma which are compatible with those from pathologic examinations.

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“…We explored two alternate scanning modalities: refraction-contrast x-ray CT (RCT) and microfocus x-ray CT (

). RCT 8 , 9 is a 3-D imaging modality that is one type of phase-contrast CT scanning based on observing the refraction of x-rays. It has very high soft tissue contrast, even for cardiac fibers.…”

Section: Introductionmentioning

confidence: 99%

Cardiac fiber tracking on super high-resolution CT images: a comparative study

et al. 2020

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Purpose: High-resolution cardiac imaging and fiber analysis methods are required to understand cardiac anatomy. Although refraction-contrast x-ray CT (RCT) has high soft tissue contrast, it cannot be commonly used because it requires a synchrotron system. Microfocus x-ray CT (μCT) is another commercially available imaging modality. Approach: We evaluate the usefulness of μCT for analyzing fibers by quantitatively and objectively comparing the results with RCT. To do so, we scanned a rabbit heart by both modalities with our original protocol of prepared materials and compared their image-based analysis results, including fiber orientation estimation and fiber tracking. Results: Fiber orientations estimated by two modalities were closely resembled under the correlation coefficient of 0.63. Tracked fibers from both modalities matched well the anatomical knowledge that fiber orientations are different inside and outside of the left ventricle. However, the μCT volume caused incorrect tracking around the boundaries caused by stitching scanning. Conclusions: Our experimental results demonstrated that μCT scanning can be used for cardiac fiber analysis, although further investigation is required in the differences of fiber analysis results on RCT and μCT.

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X-ray refraction-contrast computed tomography images using dark-field imaging optics

Cited by 39 publications

References 15 publications

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations

Cardiac fiber tracking on super high-resolution CT images: a comparative study

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